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作者：Hong, Pubin; Schmid, Bernhard; Craven, Dylan; Liang, Maowei; Luo, Mingyu; Wang, Zeyu; Yang, Chen; Zhou, Libin; Allan, Eric; Catford, Jane A.; Eisenhauer, Nico; Feng, Yanhao; Hautier, Yann; Huang, Mengjiao; Huang, Yuanyuan; Isbell, Forest; Jiang, Lin; Loreau, Michel; Reich, Peter B.; Roscher, Christiane; van Ruijven, Jasper; Tilman, David; Weigelt, Alexandra; Wang, Shaopeng
作者单位：Peking University; Universidad Mayor; Lanzhou University; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; University of Bern; University of Bern; University of London; King's College London; Australian National University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; Utrecht University; Basque Centre for Climate Change (BC3); University of Minnesota System; University of Minnesota Twin Cities; University System of Georgia; Georgia Institute of Technology; Centre National de la Recherche Scientifique (CNRS); University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Wageningen University & Research; University of California System; University of California Santa Barbara
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作者：Lew, Nellie; Raval, Devesh R.
摘要：The rapid growth of digital platforms has transformed how consumers interact with the marketplace and led to new challenges for consumer protection. This Perspective describes how the Federal Trade Commission's Bureau of Economics uses behavioral insights and empirical methods to support efforts to prevent unfair or deceptive business practices in digital markets. We highlight two studies that address critical knowledge gaps in digital consumer protection, including how consumers perceive and ...
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作者：Li, Shunyao; Mei, Yu; Xu, Kai; Sheng, Huaixuan; Chen, Yu-an; Teng, Mingda; Xu, Bohan; Jiang, Bingqian; Yu, Chengxuan; Li, Huizhu; Zhao, Shiyun; Wang, Yi; Zhang, Xiao; Zhao, Yiyang; Wang, Yueming; Wo, Yan; Li, Zhaochen; Shen, Siwen; Li, Yunxia; Tang, Min; Mei, Yongfeng; Chen, Jun; Huang, Gaoshan; Feng, Sijia
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University; The Chinese University of Hong Kong, Shenzhen; Fudan University; Fudan University; Fudan University
摘要：Biofilm-associated infections present a critical therapeutic challenge due to antibiotic resistance and impaired tissue healing. Here, we present a microrobotic system (MZ-8) that integrates real-time human-steered navigation with autonomous, microenvironment-responsive therapy to actively eradicate biofilms and promote tissue regeneration. This microrobotic system features a spine-inspired structure for mechanical biofilm disruption, a pH-responsive ZIF-8 coating for immunomodulatory Zn2+ rel...
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作者：Macedo, Marcia N.
作者单位：Columbia University; Columbia University
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作者：Pugsley, Geoffrey; Gryspeerdt, Edward; Nair, Vishnu
作者单位：Imperial College London
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作者：Zeng, Ye; Xu, Junchao; Wang, Jinjin; Xue, Lulu; Liu, Jiageng; Geisler, Hannah C.; Ma, Xu; Melamed, Jilian R.; Shi, Qiangqiang; Padilla, Marshall S.; Luo, Zhangyi; Zhu, Jingcheng; Thatte, Ajay S.; Figueroa-Espada, Christian G.; Ang, Melgious Jin Yan; Murray, Amanda M.; Yamagata, Hannah M.; Kim, Dongyoon; Metzloff, Ann E.; Weissman, Drew; Mitchell, Michael J.
作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Agency for Science Technology & Research (A*STAR); A*STAR - Bioprocessing Technology Institute (BTI); University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania
摘要：mRNA-based cancer vaccines offer a modular and safe platform to elicit antitumor immunity, yet their efficacy is often limited by inefficient mRNA delivery and inadequate dendritic cell (DC) activation, both of which are essential for initiating robust cytotoxic T cell responses. Inadequate innate immune activation coupled with poor antigen presentation further diminishes their effectiveness, particularly in immunologically cold tumors. While stimulator of interferon genes (STING) agonists can...
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作者：Zoller, Benjamin; Benichou, Alexis; Gregor, Thomas; Tkacik, Gasper
作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; Institute of Science & Technology - Austria; Princeton University
摘要：Eukaryotic gene regulation relies on stochastic yet controlled promoter switching, in which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies have revealed a surprising invariance of the switching correlation time (TC)-the characteristic decay time of the autocorrelation function of promoter activity fluctuations-across gene expression levels in multiple genes and organisms. A biophysically plausible explanat...
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作者：Scurich, Nicholas; Albright, Thomas D.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Salk Institute
摘要：Proficiency testing is widely used to assess expertise in medicine, engineering, and other high-stakes fields. In forensic science, such tests are often cited in court as evidence that pattern-comparison methods are accurate and reliable. Yet, the scientific value of proficiency testing depends on test design, scoring rules, and the extent to which results support valid inferences about real-world performance. A recent proficiency test of forensic firearm identification-the comparison of bulle...
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作者：Musso, Andrea; Rybski, Diego; Helbing, Dirk; Neffke, Frank
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The share of the world population living in cities with more than one million people rose from 11% in 1975 to 24% in 2025 (our estimates). Will this trend toward greater concentration in large cities continue or level off? We introduce two new city population datasets that use consistent city definitions across countries and over time. The first covers the world between 1975 and 2025, using satellite imagery. The second covers the United States between 1850 and 2020, using census microdata. We...
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作者：Ozker, Muge; Giglio, Laura; Beyh, Ahmad; Forkel, Stephanie J.; Hagoort, Peter
作者单位：Radboud University Nijmegen; University of Zurich; Rutgers University System; Rutgers University New Brunswick; Sorbonne Universite; University of Witwatersrand
摘要：Sensory feedback is essential for the fine-tuning of motor actions, and speech production is no exception. It depends on continuous self-monitoring to ensure that produced sounds match intended targets. Delaying auditory feedback (DAF) disrupts this alignment and impairs fluency, providing a powerful tool to investigate sensorimotor control. We combined functional and diffusion-weighted MRI in 31 participants performing a word-production task under delayed (DAF) and immediate (no-DAF) auditory...
