2026

最新文章

• Evolution of human IL4I1 preference for aromatic amino acids from a broad-specificity L-amino acid oxidase ancestor AI翻译
  作者：Massari, Marta; Caroli, Jonatan; Malatesta, Marco; Marchese, Sara; Sente, Filip; Pizzorni, Letizia; Mattevi, Andrea
  作者单位：University of Pavia
  摘要：IL4I1, a human L-amino acid oxidase (LAAO), has drawn considerable interest for its role in catabolism with implications for cancer biology and immune modulation. The function and activity of this enzyme in humans contrast with the cytotoxic effects exerted by LAAOs from snake venoms. The inherent instability of IL4I1 has hindered detailed biochemical characterization and its exploration as a drug target. In this study, we present a comprehensive biochemical and structural investigation of tet...
• Accelerating Campylobacter zoonosis in the Anthropocene AI翻译
  作者：Kyne, Oakem J.; Penman, Bridget S.; Kelly, David J.; Sheppard, Samuel K.
  作者单位：University of Oxford; University of Oxford; University of Sheffield
  摘要：Intensive poultry farming has transformed global bird populations, concentrating billions of chickens into dense industrial systems that fundamentally reshape ecological space. As birds are important pathogen reservoirs, these changes can have important consequences for the spread of zoonoses including Campylobacter jejuni-the leading cause of bacterial gastroenteritis. Analyzing 2,747 genomes from chickens and wild birds, we show that poultry intensification has eroded historic host-strain as...
• p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1 (vol 101, pg 14057, 2004) AI翻译
  作者：You, Han; Jang, YingJu; You-Ten, Annick Itie; Okada, Hitoshi; Wakeham, Andrew; Zaugg, Kathrin; Mak, Tak W.
• Rapid acceleration of ice-cover loss from Northern Hemisphere lakes above critical air temperature thresholds AI翻译
  作者：Zhou, Jian; Wang, Weijia; Ma, Yaru; Yuan, Linwang; Huang, Changchun; Shi, Kun; Leavitt, Peter R.
  作者单位：Nanjing Normal University; Nanjing Normal University; Bangor University; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; University of Regina; University of Regina
  摘要：Widespread declines in lake-ice cover are a hallmark of climate warming, yet the dynamic sensitivity of ice cover to thermal forcing remains poorly understood across broad climatic gradients. By analyzing an extensive dataset from 724 Northern Hemisphere lakes between 2000 and 2022, we quantify the responsiveness of lake-ice phenology to changes in air temperature and project their future trajectories. Our hemispheric analysis reveals a pronounced asymmetrical sensitivity where ice-decay proce...
• A structural and mechanistic atlas of NTD antibody neutralization and immune escape across SARS-CoV-2 prototype and its (sub-)variants AI翻译
  作者：Zhou, Jianjie; Li, Wenyu; Wang, Xiaoyun; Sun, Junqing; Guo, Shuxin; Rong, Xiaoyu; Tong, Zhou; Dai, Lianpan; Liu, William Jun; Qi, Jianxun; Gao, George Fu; Wang, Qihui
  作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Macau; Guangzhou Laboratory
  摘要：The N-terminal domain (NTD) of the SARS-CoV-2 spike (S) is a critical antibody target, yet its epitope organization, neutralization mechanisms, and immune evasion strategies remain incompletely resolved. Here, we classify NTD antibodies into nine spatially distinct classes (designated as NTD-1 to NTD-9), including a cryptic epitope defined here (NTD-8). Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NT...
• Rapid microbial production of long-lived dissolved organic carbon in the global ocean AI翻译
  作者：Cai, Ruanhong; Lechtenfeld, Oliver J.; Tanentzap, Andrew J.; Sachs, Julian P.; Kao, Shuh-Ji; Osterholz, Helena; Yan, Zhenwei; Zhao, Chen; Yi, Yuanbi; Li, Penghui; Zhang, Chuanlun; Jiao, Nianzhi; Koch, Boris P.; Herndl, Gerhard J.; He, Ding
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Helmholtz Association; Trent University; Carl von Ossietzky Universitat Oldenburg; University of Washington; University of Washington Seattle; Hainan University; Hainan University; Leibniz Institut fur Ostseeforschung Warnemunde; Sun Yat Sen University; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Xiamen University; Xiamen University; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Vienna; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); City University of Hong Kong; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Marine microbes have long been regarded as central to replenishing the ocean's reservoir of recalcitrant dissolved organic matter (RDOM). However, molecular-level evidence for their role remains inconclusive because RDOM persists for years to millennia, far exceeding timescales accessible to laboratory experiments, and because conventional analytical approaches lack the resolution to discern structural isomers of RDOM that confer functionally important differences in persistence. Using polarit...
• Dietary DNA in municipal wastewater reveals signatures of wealth, immigration, and coastal proximity AI翻译
  作者：Dong, Mengyi; Clerkin, Thomas Joseph; Jiang, Sharon; Ives, Nolan; Osborne, Olivia W.; Kirtley, Michelle; Bauer, Anna E.; Anderson, Katherine Y.; Smith, Martin D.; Noble, Rachel T.; David, Lawrence A.
  作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; Duke University; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Duke University
  摘要：Public health nutrition lacks scalable, objective tools for real-time dietary surveillance. We developed FoodSeq-FLOW (Food Landscape Observation in Wastewater), a genomic platform that sequences chloroplast trnL and mitochondrial 12SV5 DNA in municipal wastewater. Across 183 samples from 21 North Carolina wastewater treatment plants serving 2.1 million people, we detected 184 plant and 116 animal food taxa at a cost of < US $0.01 per person. Wastewater-derived dietary profiles correlated with...
• Source limitation drives slow compositional recovery in tropical secondary forests AI翻译
  作者：Genes, Luisa; Wendt, Amanda; Finegan, Bryan; Barber, Cristina; Delgado, Diego; Pelaez, Marta; Huanca Nunez, Nohemi; Kobe, Richard K.; Dirzo, Rodolfo; Chazdon, Robin L.
  作者单位：Stanford University; Michigan State University; Universidad Politecnica de Madrid; Yale University; Stanford University; Stanford University; University of the Sunshine Coast; University of Connecticut
  摘要：Tropical forests can recover diversity, structure, and function rapidly after disturbance. However, plant compositional recovery remains incomplete even after many decades, and the reasons for this lag are poorly understood. We investigated the roles of source, dispersal, and establishment limitation in affecting compositional recovery in Costa Rican forests using long-term data on species composition of trees, seeds, seedlings, and saplings, along with measurements of herbivory and leaf patho...
• Insights into hominin body size, locomotion, and behavior from Early Pleistocene trackways in northern Kenya AI翻译
  作者：Hatala, Kevin G.; Roach, Neil T.; Harris, John W. K.; Kiura, Purity; Ndiema, Emmanuel K.; Sila, Ben; Kipkebut, David; Waweru, Joyce; Kisale, Philiphine; Longaye, Apolo Alkoro; Sale, Hilary; Behrensmeyer, Anna K.
  作者单位：Chatham University; Max Planck Society; Harvard University; Rutgers University System; Rutgers University New Brunswick; George Washington University; Smithsonian Institution; Smithsonian National Museum of Natural History; Smithsonian Institution; Smithsonian National Museum of Natural History
  摘要：The Early Pleistocene fossils of the Koobi Fora Formation, northern Kenya, record two well-documented hominin genera, Homo and Paranthropus, preserved in the same deposits. Evidence for their ecological sympatry consists of co-occurring footprints of diverse morphologies, suggesting that Homo erectus and Paranthropus boisei were present in the same lake margin habitats over hundreds of thousands of years. Here, we report on a similar to 1.43 Ma fossil footprint assemblage that sheds light on E...
• The quantum ensemble variational optimization algorithm: Applications to molecular inverse design AI翻译
  作者：Calcagno, Francesco; Cabral, Delmar G. A.; Rivalta, Ivan; Batista, Victor S.
  作者单位：University of Bologna; University of Bologna; Yale University; Yale University
  摘要：Designing molecules with optimized properties remains a fundamental challenge due to the intricate relationship between molecular structure and properties. Traditional computational approaches that address the combinatorial number of possible molecular designs become unfeasible as the molecular size increases, suffering from the so-called curse of dimensionality problem. Recent advances in quantum computing hardware present new opportunities to address this problem. Here, we introduce the quan...