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作者：Thorp, H. Holden
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作者：Jain, Siddhant U.; Williamson, Kaylyn E.; Ying, Alexander W.; Turner, Aasha M.; Jiang, Ruidong Jerry; Raval, Shaunak; So, Kevin; Allison, Maxwell J.; Sankar, Akshay; Same Guerra, Daniel D.; Lin, Yutong; Jiang, Zhe; Mashtalir, Nazar; Rohrs, Henry W.; Lichti, Cheryl F.; Muir, Tom W.; Papanastasiou, Malvina; Paulo, Joao A.; Gygi, Steven P.; Gross, Michael L.; Kadoch, Cigall
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Washington University (WUSTL); Princeton University; Washington University (WUSTL); Washington University (WUSTL); Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT [SWI/SNF immunoglobulin fold (Ig-fold) for transcription factor interactions], a conserved transcription factor (TF) binding domain on the SMARCD subunits. SWIFT is necessary and sufficient for direct engagement with the transactivation domain of the PU.1 TF. A single ...
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作者：Rosa, Fabio F.
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作者：Zeng, Zijie; Barron, Andrew B.; Peng, Fei; Solvi, Cwyn
作者单位：Southern Medical University - China; Southern Medical University - China; Macquarie University; Southern Medical University - China
摘要：Flexible, abstract rhythm perception underpins human music, dance, and speech, but thus far, it has only been demonstrated in a few birds and mammals. In this work, we show that bumble bees also form robust abstract rhythm representations. Free-flying bees learned to discriminate two arbitrary repeating flashing light sequences, balanced to preclude the use of any local cues. Bees successfully recognized these learned rhythmic patterns at new, faster, and slower tempi. Bees trained on vibratio...
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作者：Zumalave, Sonia; Santamarina, Martin; Espasandin, Nuria P.; Zamora, Jorge; Garcia-Souto, Daniel; Temes, Javier; Baker, Toby M.; Rodriguez-Castro, Jorge; Otero, Paula; Pequeno-Valtierra, Ana; Otero, Iago; Oitaben, Ana; Alvarez, Eva G.; Diaz-Arias, Iria; Martinez-Fernandez, Monica; Blanco, Miguel G.; Van Loo, Peter; Cristofari, Gael; Rodriguez-Martin, Bernardo; Tubio, Jose M. C.
作者单位：Universidade de Santiago de Compostela; Universidade de Santiago de Compostela; Francis Crick Institute; Universidade de Santiago de Compostela; Universidade de Santiago de Compostela; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); European Molecular Biology Laboratory (EMBL); Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Pompeu Fabra University
摘要：LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read sequencing, we analyzed 10 tumors with exceptionally high retrotransposition activity, comprising more than 6000 somatic events. We reveal that L1-mediated reciprocal translocations occur frequently, typically driven by two concurrent L1 retrotransposition events on nonhomologous chromosomes. Usi...
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作者：Cai, Liping; Zhang, Qing; Yao, Tianxiong; Zou, Xiaoxiao; Xie, Lei; Yang, Siyu; Xiao, Yanyuan; Huang, Fei; Peng, Zhiwei; Yang, Jiawen; Huang, Jianzhen; Jing, Qiqi; Ling, Ziqi; Zheng, Min; Qiao, Chuanmin; Wu, Jinyuan; Chen, Jiaqi; Jiang, Tao; Liu, Qin; Liu, Min; Chen, Zhe; Li, Jingquan; Jiang, Hui; Jiang, Haoyun; Chen, Zuoquan; Liao, Yaya; Huang, Yizhong; Li, Longyun; Zhou, Yunyan; Zhang, Zhou; Yin, Chao; Ye, Yu; Yang, Hui; Chen, Biao; Wang, Zhong; Gong, Huanfa; Chen, Dong; Huang, Cong; Tong, Xinkai; Zhou, Zhimin; Fu, Hao; Sun, Yingchun; Sun, Xiao; Yan, Min; Wu, Lin; Xiong, Shuqi; Wang, Yaxiang; Xie, Xinke; Zhou, Mengqing; Liu, Xiaodong; Xie, Xianhua; Wu, Fusheng; Liu, Zifeng; Ge, Mei; Xiong, Sanya; Li, Chenyu; Shen, Tao; Liu, Yuxin; Tang, Xi; Chang, Xiaolong; Liu, Siyi; Yu, Chuangang; Yu, Naixiang; Hu, Zikang; Cui, Dengshuai; Zhong, Jiahong; Liu, Sha; Hu, Jianchao; Wen, Yang; Zhou, Weiwei; Wei, Guanyue; Lin, Shiyao; Xiahou, Yiwen; Chen, Liqing; Li, Jianjun; Liu, Ruirong; Chen, Xiaoyun; Shu, Yujie; Chen, Feng; Wei, Chao; Hu, Xiaofen; Li, Yong; Hou, Yong; Zeng, Qingjie; Gao, Jun; Su, Ying; Li, Jing; Ma, Junwu; Guo, Yuanmei; Chen, Congying; Xiao, Shijun; Ai, Huashui; Zhang, Zhiyan; Liu, Weiwei; Yang, Qiang; Xing, Yuyun; Rao, Lin; Yang, Bin; Huang, Lusheng
作者单位：Jiangxi Agricultural University; Ministry of Science and Technology, China
摘要：Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also d...
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作者：Baronas, Denis; Norvaisis, Simonas; Zvirblyte, Justina; Leonaviciene, Greta; Mikulenaite, Vincenta; Goda, Karolis; Kaseta, Vytautas; Sablauskas, Karolis; Griskevicius, Laimonas; Juzenas, Simonas; Mazutis, Linas
作者单位：Vilnius University; State Research Institute Centre for Innovative Medicine; Vilnius University; Vilnius University; Umea University
摘要：Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput single-cell omics methods and tools that efficiently probe the cellular phenotype and genotype. Here, we present a versatile technology based on semipermeable capsules (SPCs) tailored for a variety of high-throughput nucleic acid assays, including single-cell genome and mRNA sequencing, and fluorescence-activated cell sorting-based isolation of individual transcriptom...
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作者：Smith, Jennie Erin
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作者：Francis, Bailey A.; Ludwig, Latasha; He, Chang; Dobromylskyj, Melanie; Bertram, Christof A.; Aupperle-Lellbach, Heike; Wong, Hannah; Foster, Aiden P.; Arends, Mark J.; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Tatiersky, Laetitia; Castillo-Alcala, Fernanda; Rupp, Angie; Khachadoorian, Arlene; Parlak, Eda; Inglebert, Marine; Umamaheswaran, Shevaniee; Cheema, Saamin; Del Castillo Velasco-Herrera, Martin; Wong, Kim; Vermes, Ian C.; Billington, Jamie; Rottenberg, Sven; Wood, Geoffrey A.; Adams, David J.; Van Der Weyden, Louise
作者单位：Wellcome Trust Sanger Institute; University of Guelph; Cornell University; University of Bern; University of Bern; University of Veterinary Medicine Vienna; LABOKLIN GmbH & Co. KG; Technical University of Munich; University of Cambridge; University of Bristol; University of Edinburgh; University of London; University of London Royal Veterinary College; Massey University; University of Glasgow; University of Bern; University of Bern
摘要：Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor-normal tissue pairs from 13 tumor types, focusing on the feline orthologs of similar to 1000 human cancer genes. TP53 was the most frequently mutated gene, and the most recurrent copy number alterations were loss of PTEN or FAS or gain of MYC. By identifying 31 driver genes, mutational signatu...
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作者：Tong, Kangkang
作者单位：Shanghai Jiao Tong University
