2026

最新文章

• Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders AI翻译
  作者：Puszynska, Anna M.; Nguyen, Thao P.; Cangelosi, Andrew L.; Armani, Andrea; Roberts, Justin M.; Singh, Kristin A.; Cameron, James C.; Tseyang, Tenzin; Liu, Grace Y.; Lai, Steven; Sprenger, Hans-Georg; Yang, Jason; Colgan, William N.; Kedir, Jibril F.; Kajderowicz, Kathrin M.; Esantsi, Theodore K.; Lu, Yuancheng Ryan; Waite, Millenia; Kunchok, Tenzin; Lewis, Caroline A.; Schulte, Fabian; Bell, George W.; Sabatini, David M.; Weissman, Jonathan S.
  作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); University of Padua; Waters Corporation; Massachusetts Institute of Technology (MIT); Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Stanford University; Stanford Medicine; Duke University; Duke University; University of Zurich; Memorial Sloan Kettering Cancer Center; Massachusetts Institute of Technology (MIT); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of California System; University of California Berkeley; Max Planck Society; Icahn School of Medicine at Mount Sinai
  摘要：Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo during aging. Aged lysosomes in brain, heart, muscle, and white adipose tissue accumulated glycerophosphodiesters and cystine, metabolites that are causally linked to juvenile lysosomal storage disorders, Batten disease, and cystinosis. Levels of these metabolites increased linearly with age, prece...
• Detention of US seismologist by China alarms researchers AI翻译
  作者：Stone, Richard
• Geometrically driven reversible solid-liquid phase transition at the atomic scale AI翻译
  作者：Cui, Wenjun; Qian, Cheng; Lin, Weixiao; Xue, Zefan; Ge, Zhencui; Zhao, Wen; Van Tendeloo, Gustaaf; Wu, Jinsong; Ding, Feng; Sang, Xiahan; Fu, Zhengyi
  作者单位：Wuhan University of Technology; Wuhan University of Technology; Wuhan University of Technology; Anhui University; Suzhou Laboratory; China University of Petroleum; University of Antwerp
  摘要：Atomic-resolution observation of the liquid-solid phase transition within a geometrically confined nanocluster provides fundamental insights into heterogeneous nucleation mechanisms. In this work, using in situ transmission electron microscopy, we directly control and observe a single critical-sized bismuth nanocluster within a tunable nanoscale gap, driving it through a reversible cycle from quasi-amorphous nanodisc, to crystalline nanowire, to liquid nanodroplet. The cluster's aspect ratio, ...
• Tidying up aging organs AI翻译
  作者：FitzGerald, Garret A.
  作者单位：University of Pennsylvania; Pennsylvania Medicine
• The mechanics of liver regeneration AI翻译
  作者：Maeso-Diaz, Raquel; Diehl, Anna Mae
  作者单位：Duke University
• Stop the biodiversity sampling arms race AI翻译
  作者：Wu, Yun-He; Zhang, Dongru; Shen, Wenjing; Zhang, Tianyi; Kilunda, Felista Kasyoka; Xu, Wei
  作者单位：Nanjing Normal University; Liupanshui Normal University; Tel Aviv University
• Laser-boosted microscopy opens view of elusive proteins AI翻译
  作者：Dolgin, Elie
• Chile's regulatory rollback harms biosphere AI翻译
  作者：Navedo, Juan G.; Benitez, Hugo A.; Dorador, Cristina; Vargas-Chacoff, Luis
  作者单位：Universidad Austral de Chile; Universidad de Extremadura; Universidad Andres Bello; Universidad de Antofagasta; Universidad de Antofagasta; Universidad Austral de Chile
• Improve genetic quality control to increase rigor and reproducibility of mouse research AI翻译
  作者：Pardo-Manuel de Villena, Fernando; Amos-Landgraf, James M.; Bell, Timothy A.; Blanchard, Matthew W.; Brennan, Jennifer; Carlson, Charisse; Ciavatta, Dominic J.; Cotney, Paul A.; Ferris, Martin T.; Hock, Pablo; Korf, Ian; Lloyd, K. C. Kent; Lutz, Cathleen; Lynch, Rachel M.; Magnuson, Terry; Murray, Stephen A.; Patel, Samit; Reinholdt, Laura G.; Sigmon, John Sebastian; Willis, Brandon; Xenakis, James G.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Missouri System; University of Missouri Columbia; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California Davis; Jackson Laboratory; University of North Carolina; University of North Carolina Chapel Hill
• Lessons in resistance from Tim Snyder AI翻译
  作者：Thorp, H. Holden