2026

最新文章

• In search of meaning AI翻译
  作者：Perlman, Marcus; Winter, Bodo
  作者单位：University of Birmingham
• Evolution of error correction through a need for speed AI翻译
  作者：Ravasio, Riccardo; Husain, Kabir; Evans, Constantine G.; Phillips, Rob; Ribezzi-Crivellari, Marco; Szostak, Jack W.; Murugan, Arvind
  作者单位：University of Chicago; University of London; University College London; University of London; University College London; Maynooth University; California Institute of Technology; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University of Chicago; Howard Hughes Medical Institute
  摘要：Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to evolve when selection for fidelity outweighs costs in energy and the speed of replication. We show that when stalling after misincorporations is accounted for, proofreading can instead speed up replication. Consistent with data on polymerase mutagenesis, our results suggest that proofreading can e...
• Hidden industry ties pervade social media research AI翻译
  作者：Kupferschmidt, Kai
• Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity AI翻译
  作者：Liu, Danhui; Zhou, Chuanli; Wang, Xiaochen; Luo, Zhou; Xu, Ruiyao; Huo, Shanshan; Guo, Lina; Luo, Xuemei; Yang, Shuhan; Click, Arielle; Vancil, Janiece; Barajas, Paola; Mijares, Victor; Baniasadi, Hamid; Yan, Nan; Rehwinkel, Jan; Hancks, Dustin C.; Chen, Elizabeth H.; Liang, Shuang; Zhong, Zhenyu
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Oxford; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Hebei Agricultural University
  摘要：Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome hyperactivation and excessive interleukin (IL)-1 beta production in macrophages by disrupting SAM and HD domain-containing protein 1 (SAMHD1), a deoxynucleoside triphosphate (dNTP) hydrolase crucial for nucleotide balance. This caused aberrant accumulation of dNTPs, which can be transported into mitochondria, and init...
• China maps the deep scars of its geological past AI翻译
  作者：Stone, Richard
• Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes AI翻译
  作者：Kong, Lingran; Zong, Kevin; Hopfengaertner, Marcus; Orzolek, Brandon J.; Shenvi, Ryan
  作者单位：Scripps Research Institute; Scripps Research Institute; University of Erlangen Nuremberg; Scripps Research Institute
  摘要：Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal catalysts have recently demonstrated competence in cross-coupling transformations through iterative outer-sphere reactions in which product bond formation occurs by serial additions to the ligand, not the metal. Despite the emerging diversity of two-component outer-sphere reactions, comparable mult...
• A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease AI翻译
  作者：Pang, Jiyi; Al-Ani, Aysha H.; Patel, Komal M.; Zhou, Yunzhuo; Young, Samuel N.; Chen, Jinjin; Kong, Isabella; Barrios, Marilou; Rickard, James A.; Chen, Siqi; Ma, Xiuquan; Shojaee, Farzaneh; Kim, Seong-Beom; Foroughi, Siavash; Cawthorne, Wayne; Jacobsen, Annette V.; Jois, Asha; Weir, Ashley L.; Whitehead, Lachlan W.; Rajasekhar, Pradeep; Horne, Christopher R.; Lyu, Ruqian; Mather, Lucy J.; Yip, Raymond K. H.; Tsui, Ellen; Azeez, Imadh; Tan, Tao; Liang, Weiwei; Sivanesan, Suresh; Metz, Andrew; Patwardhan, Ash; Shea, Natalie; Iyngkaran, Guru; Schneider, Daniel; Elford, Alexander T.; Beattie, William; Macrae, Finlay; Liccardi, Gianmaria; Walczak, Henning; Zhang, Yuxia; Sieber, Oliver M.; Spelman, Tim; Giulino-Roth, Lisa; Christie, Michael; Chen, Yunshun; Rogers, Kelly L.; Bowden, Rory; Nicholson, Sandra E.; Lawlor, Kate E.; Hawkins, Edwin D.; Christensen, Britt; Samson, Andre L.; Vince, James E.; Murphy, James M.
  作者单位：Walter & Eliza Hall Institute; University of Melbourne; Melbourne Health; Royal Melbourne Hospital; University of Melbourne; Cornell University; Weill Cornell Medicine; Nankai University; Ulsan National Institute of Science & Technology (UNIST); Royal Children's Hospital Melbourne; Monash University; Guangzhou Medical University; Zhengzhou University; University of Cologne; University of Cologne; University of Cologne; University of London; University College London; Hudson Institute of Medical Research; Monash University
  摘要：Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to correct these imbalances to induce remission, most patients ultimately relapse, suggesting that key pathogenic mechanisms persist. Here, we identified aberrant epithelial cell death signaling as an underlying feature of IBD that arises in patients in remission and on advanced therapy. Mechanistically...
• Promoter-driven recrystallization affording highly textured ruthenium AI翻译
  作者：Leem, Youngchul; Ha, Yoonhoo; Lee, Young-Min; Jo, Yong-Ryun; Lee, Jeong Yub; Cho, Eun-Hyoung; Chae, Byeong-Gyu; Lee, Jaewoo; Jo, Gi-Young; Park, Seong Yong; Byun, Kyung-Eun; Kim, Jeehwan; Kim, Sang Won
  作者单位：Gwangju Institute of Science & Technology (GIST); Samsung; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：The electrical properties of polycrystalline materials are governed by crystallite characteristics and spatial arrangement. We grew ruthenium polycrystals with a near-complete out-of-plane preferred orientation and predominantly low-energy grain boundaries on amorphous dielectric substrates, without relying on epitaxial growth or lattice-matched conditions. Whereas prior studies used high-density, high-quality polycrystalline materials derived from high-purity sources, we exploited trace carbo...
• An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease AI翻译
  作者：Cottle, Thomas; Joh, Lydia; Posner, Cori; DeCosta, Adam; Campagna, Dean R.; Fleming, Mark D.; Ducamp, Sarah; Kardon, Julia R.
  作者单位：Brandeis University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School
  摘要：Heme biosynthesis is tightly coordinated to support essential functions without accumulating toxic porphyrins and depleting cellular iron. Heme induces degradation of the heme biosynthetic enzyme, 5-aminolevulinate synthase (ALAS), by the mitochondrial caseinolytic protease complex CLPX-CLPP (CLPXP), but the mechanism for heme-triggered degradation had not been elucidated. We found that polymerase delta-interacting protein 2 (POLDIP2) is a heme-sensing adaptor protein sufficient to reconstitut...
• Enabling sustainable supply of the essential cancer medicines etoposide and teniposide in yeast AI翻译
  作者：Shen, Siyu; Hu, Xue; Li, Dan; Tong, Yuru; Lv, Yunpeng; Tian, Zhenjiang; Wang, Jiadian; Tang, Hao; Wang, Yapeng; Kang, Lan; Nielsen, Jens; Huang, Luqi; Hu, Yating
  作者单位：Capital Medical University; National Resource Center for Chinese Materia Medica, CACMS; China Academy of Chinese Medical Sciences; Capital Medical University; Chalmers University of Technology
  摘要：Lignans constitute a diverse family of plant metabolites with therapeutic potential. Among them, podophyllotoxin-type aryltetralin lignans serve as precursors for etoposide and teniposide. Etoposide is an essential anticancer medicine approved for first-line treatment of small cell lung cancer, whereas teniposide is used for treatment of leukemia and some brain tumors. Currently, these drugs depend on extraction of precursors from the endangered plant Sinopodophyllum hexandrum, followed by che...