2026

最新文章

• Contagious fish cancer overruns New England lake AI翻译
  作者：Appenzeller, Tim
• A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation AI翻译
  作者：Cheng, Yubao; Wang, Jianshu; Zhang, Yuan; Yadavalli, Anurupa Devi; Liu, Miao; Jin, Shengyan; Buddle, Grace; Haberman, Ann; Schatz, David G.; Wang, Siyuan
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale New Haven Hospital.
  摘要：B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influences SHM is not fully understood. We leveraged sequencing-based and image-based 3D genomics and transcriptomics to map single-cell 3D genome organization and gene expression across cell types and states in human tonsils and in B cell lymphoma cell lines. These analyses revealed trajectories of comp...
• Seabed mining requires timely governance AI翻译
  作者：Ruhlemann, Carsten
• Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging AI翻译
  作者：Tan, Yuting Jessy; Conley, Travis E.; Yao, Fuwen; Garcia-Marques, Fernando J.; Akinyemi, Damilola E.; Dinh, Van Vuong; Wang, Qian; Bermudez, Abel; Kim, Jieun; Belk, Julia A.; Soehnlein, Oliver; Pitteri, Sharon J.; Andreasson, Katrin I.
  作者单位：Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
  摘要：Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescent neutrophils, a process regulated by the immunomodulatory prostaglandin E2 (PGE2) receptor EP2. Reducing TRM EP2 signaling in aged mice preserved youthful mitochondrial fitness and prevented cognitive decline, frailty, sarcopenia, adiposity, cardiac impairment, and systemic inflammation. Plasma p...
• Illuminating the molecular basis of human daylight vision AI翻译
  作者：Schmidt, Sarah L.; Dostal, Jakub; Sen, Saumik; Hovan, Andrej; Walter, Deborah; Appleby, Martin V.; Kojima, Asato; Kato, Hideaki E.; Beale, John H.; Kloz, Miroslav; Schertler, Gebhard F. X.; Isaikina, Polina
  作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Institute of Bioinformatics; University of Zurich; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; University of Tokyo; University of Tokyo; Japan Science & Technology Agency (JST); Japan Science & Technology Agency (JST)
  摘要：Photopic vision, including fast motion and color perception in daylight, is mediated by cone opsins, specialized G protein-coupled receptors (GPCRs). Despite sharing the same chromophore, the three receptor subtypes absorb light at different wavelengths of the visible spectrum. The molecular mechanisms governing their spectral properties and exceptionally rapid responses remain largely unknown. We report cryo-electron microscopy structures of the human blue-sensitive (OPN1SW) and green-sensiti...
• Scientists to spend 8 months drifting in Arctic ice AI翻译
  作者：Stone, Richard
• Dorothy Hodgkin: A Life AI翻译
  作者：[Anonymous]
• Britain's next research choice AI翻译
  作者：Johnson, Ben; Stone, Will
  作者单位：University of Strathclyde
• Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain AI翻译
  作者：Wu, Haixu; Chen, Duoyuan; Li, Jun; Zhou, Tao; Zhuang, Zhenkun; Niu, Zhiwei; Du, Zeyu; Chen, Yongjie; Chuan, Shunqin; Xu, Chunyan; Liao, Xun; Meng, Xiaoyu; Lu, Jiali; Cui, Wenxue; Lin, Youning; Huang, Fubaoqian; Liao, Kuo; Liu, Yan; Yang, Tao; Chen, Jing; Wang, Hui; Dong, Zhiqiang; Liu, Longqi; Fang, Xiaodong; Xu, Xun; Li, Qingwei; Pang, Yue; Liu, Shiping; Su, Bing
  作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Liaoning Normal University; Beijing Genomics Institute (BGI); Liaoning Normal University; Beijing Genomics Institute (BGI); Huazhong Agricultural University; Chinese Academy of Sciences
  摘要：The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of the lamprey brain, identifying 209 distinct cell clusters across 14 regions. Cross-species comparisons revealed broad conservation of regional spatial architecture, defining an ancestral organizational blueprint. Within this conserved framework, however, marked lineage-specific divergence emerged...
• Fires reverse progress toward ozone air quality standards in the United States AI翻译
  作者：Deng, Weizhi; Wang, Jun; Zhou, Meng; Chen, Xi; Wu, Xiaodong; Zhang, Huanxin; Cohen, Jason B.; Wei, Jing; da Silva, Arlindo; Brasseur, Guy P.; Granier, Claire; Rouil, Laurence
  作者单位：University of Iowa; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Iowa; University System of Maryland; University of Maryland College Park; National Center Atmospheric Research (NCAR) - USA; Max Planck Society; Universite de Toulouse (EPE); Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); LAERO; National Oceanic Atmospheric Admin (NOAA) - USA; University of Colorado System; University of Colorado Boulder
  摘要：Recent surges in wildfire emissions have exacerbated surface ozone pollution in the United States. Using deep learning, we developed a gapless daily surface ozone dataset at 1-kilometer resolution for 2003-2024. This dataset revealed a reversal in national policy-relevant ozone trends that had gone undetected by the sparse monitoring network: from -0.65 parts per billion (ppb) per year (2003-2015) to +0.13 ppb per year (2015-2024). The reversal was primarily driven by increasing wildfire emiss...