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作者:Skopintsev, Petr; Esain-Garcia, Isabel; DeTurk, Evan C.; Yoon, Peter H.; Zhou, Zehan; Weiss, Trevor; Kamalu, Maris; Chamraj, Ajit; Loi, Kenneth J.; Langeberg, Conner J.; Boger, Ron S.; Nisonoff, Hunter; Karp, Hannah M.; Chen, Lin-Xing; Shi, Honglue; Vohra, Kamakshi; Banfield, Jillian F.; Cate, Jamie H. D.; Jacobsen, Steven E.; Doudna, Jennifer A.
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Monash University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Los Angeles; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要:The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic properties remains challenging. Here, we use a protein design strategy that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs. High-throughput screening ...
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作者:Daniels, Ronald J.
作者单位:Norwegian Meteorological Institute
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作者:Zheng, Xin; Valov, Ilia
作者单位:Helmholtz Association; Julich Research Centre; Bulgarian Academy of Sciences
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作者:Kim, Seok-Jin; Maligal-Ganesh, Raghu V.; Mahmood, Javeed; Kang, Phil Woong; Harale, Aadesh; AlSuhaibani, Abdulrahman S.; Hu, Qingyuan; Alahmed, Ammar H.; Jamal, Aqil; Suleiman, Rukaiyat; Baaqel, Husain; Atilhan, Mert; Sarathy, S. Mani; Yavuz, Cafer T.
作者单位:King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; Sungkyunkwan University (SKKU); KREA University; Saudi Aramco; King Abdullah University of Science & Technology; Royal Commission For Jubail & Yanbu; Jubail Industrial College; Western Michigan University
摘要:Strategies for lowering carbon emissions from hydrocarbons and waste must overcome the challenges related to catalyst durability and the presorting of waste. Reforming low-value carbon sources with carbon dioxide (CO2) offers an industrial-scale pathway for recycling waste streams into fuels and chemicals. We developed a nickel-molybdenum alloy nanocatalyst on single-crystalline magnesium oxide (NiMoCat) in pellet form on a kilogram scale suitable for high-pressure industrial reactors. Aliphat...
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作者:Shen, Jianchang; Zhou, Guangdi; Miao, Yu; Li, Peng; Ou, Zhipeng; Chen, Yaqi; Wang, Zechao; Luan, Runqing; Sun, Hongxu; Feng, Zikun; Yong, Xinru; Li, Yueying; Xu, Lizhi; Lv, Wei; Nie, Zihao; Wang, Heng; Huang, Haoliang; Sun, Yu-Jie; Xue, Qi-Kun; He, Junfeng; Chen, Zhuoyu
作者单位:Chinese Academy of Sciences; University of Science & Technology of China, CAS; Southern University of Science & Technology; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Tsinghua University
摘要:The discovery of superconductivity in Ruddlesden-Popper bilayer nickelate films under ambient pressure provides an opportunity to directly investigate electronic energy scales of the superconducting state and the pairing mechanism. We report angle-resolved photoemission spectroscopy measurements of superconducting (La,Pr,Sm)(3)Ni2O7 thin films by developing an ultrahigh-vacuum cryogenic sample quenching and transfer technique. A superconducting gap of similar to 18 milli-electron volts with co...
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作者:Vogel, Gretchen
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作者:Curry, Andrew
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作者:Cohen, Jon
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作者:Ibrahim, Tarhan; King, Freddie J.; Toghani, AmirAli; Wang, Luyao; Jenkins, Saskia; Yuen, Enoch Lok Him; Wang, Hung-Yu; Vuolo, Cristina; Eilmann, Nick; Adamkova, Vanda; Chia, Khong-Sam; Castel, Baptiste; Jones, Jonathan D. G.; Carella, Philip; Wu, Chih-Hang; Kourelis, Jiorgos; Kamoun, Sophien; Bozkurt, Tolga O.
作者单位:Imperial College London; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Academia Sinica - Taiwan; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Centre
摘要:Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)-permeable channels and triggering immunity. Here, we found that the RPW8-like coiled-coil NLR (CCR-NLR) N requirement gene 1 (NRG1) primarily targets organelles instead of the plasma membrane. Unlike canonical CC-NLRs, activated NRG1 accumulated at the chloroplast envelope and channeled stromal Ca2+ ...
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作者:Shi, Qibin; Montgomery, David R.; Swann, Abigail L. S.; Cristea, Nicoleta C.; Williams, Ethan F.; You, Nan; Jeffery, Simon; Collins, Joe; Barrio, Ana Prada; Misiewicz, Paula A.; Nissen-Meyer, Tarje; Denolle, Marine A.
作者单位:Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Rice University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Santa Cruz; Purdue University System; Purdue University; Harper Adams University; University of Exeter
摘要:The impacts of farming practices on soil hydrodynamics are central to understanding agricultural landscapes covering almost half of the world's habitable land. Combining observations from distributed acoustic sensing with physics-based hydromechanical modeling, we tracked minute-resolution and meter-scale seismic and hydrological changes across agricultural fields with controlled histories of tillage and compaction. We show that dynamic capillary effects in soil govern transient stiffness and ...