2026

最新文章

• Structure and evolution-guided design of minimal RNA-guided nucleases AI翻译
  作者：Skopintsev, Petr; Esain-Garcia, Isabel; DeTurk, Evan C.; Yoon, Peter H.; Zhou, Zehan; Weiss, Trevor; Kamalu, Maris; Chamraj, Ajit; Loi, Kenneth J.; Langeberg, Conner J.; Boger, Ron S.; Nisonoff, Hunter; Karp, Hannah M.; Chen, Lin-Xing; Shi, Honglue; Vohra, Kamakshi; Banfield, Jillian F.; Cate, Jamie H. D.; Jacobsen, Steven E.; Doudna, Jennifer A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Monash University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Los Angeles; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic properties remains challenging. Here, we use a protein design strategy that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs. High-throughput screening ...
• Johns Hopkins University and the American research enterprise AI翻译
  作者：Daniels, Ronald J.
  作者单位：Norwegian Meteorological Institute
• Computing in a memory with physics AI翻译
  作者：Zheng, Xin; Valov, Ilia
  作者单位：Helmholtz Association; Julich Research Centre; Bulgarian Academy of Sciences
• Industrial-scale nanocrystalline Ni-Mo-MgO catalysts for hybrid reforming of waste to fuels AI翻译
  作者：Kim, Seok-Jin; Maligal-Ganesh, Raghu V.; Mahmood, Javeed; Kang, Phil Woong; Harale, Aadesh; AlSuhaibani, Abdulrahman S.; Hu, Qingyuan; Alahmed, Ammar H.; Jamal, Aqil; Suleiman, Rukaiyat; Baaqel, Husain; Atilhan, Mert; Sarathy, S. Mani; Yavuz, Cafer T.
  作者单位：King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; Sungkyunkwan University (SKKU); KREA University; Saudi Aramco; King Abdullah University of Science & Technology; Royal Commission For Jubail & Yanbu; Jubail Industrial College; Western Michigan University
  摘要：Strategies for lowering carbon emissions from hydrocarbons and waste must overcome the challenges related to catalyst durability and the presorting of waste. Reforming low-value carbon sources with carbon dioxide (CO2) offers an industrial-scale pathway for recycling waste streams into fuels and chemicals. We developed a nickel-molybdenum alloy nanocatalyst on single-crystalline magnesium oxide (NiMoCat) in pellet form on a kilogram scale suitable for high-pressure industrial reactors. Aliphat...
• Nodeless superconducting gap and electron-boson coupling in (La,Pr,Sm)3Ni2O7 films AI翻译
  作者：Shen, Jianchang; Zhou, Guangdi; Miao, Yu; Li, Peng; Ou, Zhipeng; Chen, Yaqi; Wang, Zechao; Luan, Runqing; Sun, Hongxu; Feng, Zikun; Yong, Xinru; Li, Yueying; Xu, Lizhi; Lv, Wei; Nie, Zihao; Wang, Heng; Huang, Haoliang; Sun, Yu-Jie; Xue, Qi-Kun; He, Junfeng; Chen, Zhuoyu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Southern University of Science & Technology; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Tsinghua University
  摘要：The discovery of superconductivity in Ruddlesden-Popper bilayer nickelate films under ambient pressure provides an opportunity to directly investigate electronic energy scales of the superconducting state and the pairing mechanism. We report angle-resolved photoemission spectroscopy measurements of superconducting (La,Pr,Sm)(3)Ni2O7 thin films by developing an ultrahigh-vacuum cryogenic sample quenching and transfer technique. A superconducting gap of similar to 18 milli-electron volts with co...
• Hour of the wolf AI翻译
  作者：Vogel, Gretchen
• Ghost of long-extinct ancestor lives on in people today AI翻译
  作者：Curry, Andrew
• Arrest of Fauci aide for records violations decried as political AI翻译
  作者：Cohen, Jon
• A helper NLR channels organellar calcium to trigger plant immunity AI翻译
  作者：Ibrahim, Tarhan; King, Freddie J.; Toghani, AmirAli; Wang, Luyao; Jenkins, Saskia; Yuen, Enoch Lok Him; Wang, Hung-Yu; Vuolo, Cristina; Eilmann, Nick; Adamkova, Vanda; Chia, Khong-Sam; Castel, Baptiste; Jones, Jonathan D. G.; Carella, Philip; Wu, Chih-Hang; Kourelis, Jiorgos; Kamoun, Sophien; Bozkurt, Tolga O.
  作者单位：Imperial College London; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Academia Sinica - Taiwan; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Centre
  摘要：Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)-permeable channels and triggering immunity. Here, we found that the RPW8-like coiled-coil NLR (CCR-NLR) N requirement gene 1 (NRG1) primarily targets organelles instead of the plasma membrane. Unlike canonical CC-NLRs, activated NRG1 accumulated at the chloroplast envelope and channeled stromal Ca2+ ...
• Agroseismology and the impact of farming practices on soil hydrodynamics AI翻译
  作者：Shi, Qibin; Montgomery, David R.; Swann, Abigail L. S.; Cristea, Nicoleta C.; Williams, Ethan F.; You, Nan; Jeffery, Simon; Collins, Joe; Barrio, Ana Prada; Misiewicz, Paula A.; Nissen-Meyer, Tarje; Denolle, Marine A.
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Rice University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Santa Cruz; Purdue University System; Purdue University; Harper Adams University; University of Exeter
  摘要：The impacts of farming practices on soil hydrodynamics are central to understanding agricultural landscapes covering almost half of the world's habitable land. Combining observations from distributed acoustic sensing with physics-based hydromechanical modeling, we tracked minute-resolution and meter-scale seismic and hydrological changes across agricultural fields with controlled histories of tillage and compaction. We show that dynamic capillary effects in soil govern transient stiffness and ...