作者：Han, Lijie; Li, Min; Li, Chuang; Zhao, Bosi; Wang, Zhongyi; Liu, Ye; Liu, Zhihan; Huang, Yafei; Liu, Liu; Geng, Haoran; He, Yuting; Guo, Jingyu; Wang, Shaoyun; Wang, Liming; Gu, Chaoheng; Shen, Junjun; Li, Zheng; Zhao, Jianyu; Zhou, Zhaoyang; Zhang, Xiaolan
作者单位：China Agricultural University; Northwest A&F University - China
摘要：Sex determination underpins genesis of male and female flowers with particularly important implications in plant breeding. Auxin and ethylene regulate femaleness in cucurbits. In this work, we identified an auxin response factor 3 (CsARF3) that plays an essential role in carpel development in cucumber. Deletion of CsARF3 resulted in an androecious phenotype with only male flowers, whereas overexpression of CsARF3 led to an increased number of female flowers. CsARF3 promotes femaleness by direc...
作者：Swarr, Amanda Lock
作者单位：University of Washington; University of Washington Seattle
作者：Thompson, Mackenzie J.; Tessier, Christian J. G.; Ananchenko, Anna; Henault, Camille; Emlaw, Johnathon R.; Dehez, Francois; Zarkadas, Eleftherios; dacosta, Corrie J. B.; Nury, Hugues; Baenziger, John E.
作者单位：University of Ottawa; University of Ottawa; Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine; European Molecular Biology Laboratory (EMBL); CEA; Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University of California System; University of California Berkeley; Carleton University; Rockefeller University
摘要：Communication at synapses is facilitated by postsynaptic receptors, which convert a chemical signal into an electrical response. For ligand-gated ion channels, agonist binding triggers rapid transitions through intermediate states leading to a transient open-pore conformation, with these transitions shaping the postsynaptic response. In this work, we determine structures of the muscle-type nicotinic acetylcholine receptor in unliganded, mono-liganded, and di-liganded states. Agonist binding to...
