-
作者:Clery, Daniel
-
作者:Mahdavi, Paasha; Ross, Michael L.
作者单位:University of California System; University of California Santa Barbara; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
-
作者:Malescot, Antoine; Malheiros-Lima, Milene R.; Zana, Laurianne; Bennett, Michael C.; Martineau, Eric; Schmid, Franca; Rungta, Ravi L.
作者单位:Universite de Montreal; Universite de Montreal; Universite de Montreal; University of Bern
摘要:The brain's vascular system dynamically regulates energy supply through neurovascular coupling. In this study, we show that in mice, neurovascular coupling is modality-dependent: Distinct sensory inputs recruit specific arteriole types, producing differential laminar blood flow patterns. Using multiscale optical imaging, we compared neuronal and vascular responses to touch, nociception, motor-sensory feedback, and spontaneous activity. Shallow arteriole dilation emerges with increasing superfi...
-
作者:Campbell, J. Elliott; Geyer, Roland
作者单位:University of California System; University of California Santa Cruz; University of California System; University of California Santa Barbara
摘要:Internal combustion engine (ICE) vehicles represent the single largest source of carbon dioxide emissions for most US households. Although battery electric vehicles (BEVs) considerably reduce use-phase emissions, the transition poses a fundamental life cycle optimization challenge: Is there a net climate benefit to retiring a functional ICE vehicle before its end of life? Retiring a functioning ICE vehicle incurs a fundamental trade-off between BEV manufacturing emissions and decreased vehicle...
-
作者:Kupferschmidt, Kai
-
作者:Rees, Geraint; Wilsdon, James
作者单位:University of London; University College London; University of London; University College London
-
作者:Rong, Xuejun; Xiao, Jun; Zhao, Xinyuan; Yan, Yan; Li, Jing; Chen, Yifan; Fan, Yihua; Liu, Zhichao; Cao, Yue; Cao, Fan; Cheng, Rui; Wang, Xionglue; Wang, Longfei; Zhu, Bin
作者单位:Huazhong University of Science & Technology; Wuhan University; Shenzhen Huazhong University of Science & Technology Research Institute
摘要:Defense-associated reverse transcriptases (DRTs) transcribe noncoding RNAs (ncRNAs) for antiviral defense, but the mechanisms of ncRNA-independent DRTs remain unclear. In this work, we show that a single DRT4 mediates RNA-targeting antiphage defense by integrating DNA polymerase, exonuclease, and RNA endonuclease activities. First, through an equilibrium between its DNA polymerase and exonuclease activities, DRT4 senses phage infection, as elevated deoxynucleotide triphosphate levels shift the...
-
作者:Kemp, Christopher
作者单位:Michigan State University
-
作者:Smith, Jennie Erin
-
作者:Thorp, H. Holden