Magnetic soft microrobots for erectile dysfunction therapy

• 成果类型: Article
• 署名作者: Wang, Shuting; Wang, Zhenqing; Shen, Zongshan; Zhang, Min; Jin, Dongdong; Zheng, Ke; Liu, Xuemin; Chai, Muyuan; Wang, Zhenxing; Chi, Ani; Ostrovidov, Serge; Wu, Hongkai; Shao, Dan; Liu, Guihua; Wu, Kai; Leong, Kam W.; Shi, Xuetao
• 署名单位: South China University of Technology; South China University of Technology; South China University of Technology; Shandong First Medical University & Shandong Academy of Medical Sciences; Sun Yat Sen University; Sun Yat Sen University; Harbin Institute of Technology; Dongguan University of Technology; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Hong Kong University of Science & Technology; South China University of Technology; Columbia University; Sun Yat Sen University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11546
• DOI: 10.1073/pnas.2407809121
• 发表日期: 2024-12-03
• 关键词: stromal cells; stem-cells; tissue; physiology

摘要

Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpus cavernosum tissue. Here, we developed an innovative magnetic soft microrobot comprising an ultrasoft hydrogel microsphere embedded with a magnetic nanoparticle chain for MSC delivery. This design also features phenylboronic acid groups for scavenging reactive oxygen species (ROS). With a Young's modulus of less than 1 kPa, the ultrasoft microrobot adapts its shape within narrow blood vessels, ensuring a uniform distribution of MSCs within the corpus cavernosum. Our findings showed that treatment facilitates nerve and blood vessel regeneration in the corpus cavernosum by of microrobots for other cell therapies.