14期

最新文章

• Feedforward and feedback mechanisms cooperatively regulate rapid experience- dependent response adaptation in a single thermosensory neuron type AI翻译
  作者：Hill, Tyler J.; Sengupta, Piali
  作者单位：Brandeis University
  摘要：Sensory adaptation allows neurons to adjust their sensitivity and responses based on recent experience. The mechanisms that mediate continuous adaptation to stimulus history over seconds- to hours-long timescales, and whether these mechanisms can operate within a single sensory neuron type, are unclear. The single pair of AFD thermosensory neurons in Caenorhabditis elegans exhibits experience- dependent plasticity in their temperature response thresholds on both minutes- and hours-long timesca...
• Unraveling sources of emission heterogeneity in Silicon Vacancy color centers with cryo-cathodoluminescence microscopy AI翻译
  作者：Angell, Daniel K.; Li, Shuo; Utzat, Hendrik; Thurston, Matti L. S.; Liu, Yin; Dahl, Jeremy; Carlson, Robert; Shen, Zhi-Xun; Melosh, Nicholas; Sinclair, Robert; Dionne, Jennifer A.
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
  摘要：Diamond color centers have proven to be versatile quantum emitters and exquisite sensors of stress, temperature, electric and magnetic fields, and biochemical processes. Among color centers, the silicon -vacancy (SiV-) defect exhibits high brightness, minimal phonon coupling, narrow optical linewidths, and high degrees of photon indistinguishability. Yet the creation of reliable and scalable SiV--based color centers has been hampered by heterogeneous emission, theorized to originate from surfa...
• Structural and mechanistic basis of the central energy- converting methyltransferase complex of methanogenesis AI翻译
  作者：Aziz, Iram; Kayastha, Kanwal; Kaltwasser, Susann; Vonck, Janet; Welsch, Sonja; Murphy, Bonnie J.; Kahnt, Jorg; Wu, Di; Wagner, Tristan; Shima, Seigo; Ermler, Ulrich
  作者单位：University of Punjab; Leiden University; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society
  摘要：Methanogenic archaea inhabiting anaerobic environments play a crucial role in the global biogeochemical material cycle. The most universal electrogenic reaction of their methane- producing energy metabolism is catalyzed byN5- methyl- tetrahydromethanopterin: coenzyme M methyltransferase (MtrABCDEFGH), which couples the vectorial Na+ transport with a methyl transfer between the one- carbon carriers tetrahydromethanopterin and coenzyme M via a vitamin B12 derivative (cobamide) as prosthetic grou...
• Improved RNA stability estimation through Bayesian modeling reveals most Salmonella transcripts have subminute half- lives AI翻译
  作者：Jenniches, Laura; Michaux, Charlotte; Popella, Linda; Reichardt, Sarah; Vogel, Joerg; Westermann, Alexander J.; Barquist, Lars
  作者单位：Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Wurzburg; University of Toronto; University Toronto Mississauga
  摘要：RNA decay is a crucial mechanism for regulating gene expression in response to environmental stresses. In bacteria, RNA- binding proteins (RBPs) are known to be involved in posttranscriptional regulation, but their global impact on RNA half - lives has not been extensively studied. To shed light on the role of the major RBPs ProQ and CspC/E in maintaining RNA stability, we performed RNA sequencing of Salmonella enterica over a time course following treatment with the transcription initiation i...
• A sodium- dependent trehalose transporter contributes to anhydrobiosis in insect cell line, Pv11 AI翻译
  作者：Mizutani, Kosuke; Yoshida, Yuki; Nakanishi, Eita; Miyata, Yugo; Tokumoto, Shoko; Fuse, Hiroto; Gusev, Oleg; Kikuta, Shingo; Kikawada, Takahiro
  作者单位：University of Tokyo; National Agriculture & Food Research Organization - Japan; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Juntendo University; Ibaraki University
  摘要：Pv11 is the only animal cell line that, when preconditioned with a high concentration of trehalose, can be preserved in the dry state at room temperature for more than one year while retaining the ability to resume proliferation. This extreme desiccation tolerance is referred to as anhydrobiosis. Here, we identified a transporter that contributes to the recovery of Pv11 cells from anhydrobiosis. In general, the solute carrier 5 (SLC5)-type secondary active transporters cotransport Na+ and carb...
• Hydroclimatic changes on multiple timescales since 7800 y BP in the winter precipitation-dominated Central Asia AI翻译
  作者：Tan, Liangcheng; Cheng, Hai; Li, Dong; Orozbaev, Rustam; Li, Yanzhen; Xu, Hai; Edwards, R. Lawrence; Song, Yougui; Ma, Le; Lin, Fangyuan; Sinha, Ashish; An, Zhisheng
  作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Xi'an Jiaotong University; Chang'an University; National Academy of Sciences of the Kyrgyz Republic (NAS KR); Tianjin University; University of Minnesota System; University of Minnesota Twin Cities; Beijing Normal University
  摘要：Central Asia (CA) is one of the world's most significant arid regions, which is markedly impacted by global warming. A better understanding of the dynamical processes governing its Holocene climate variability is critical for a better understanding of possible future impacts of climate change in the region. To date, most of the existing CA paleoclimate records are from the summer precipitation-dominated eastern CA (ECA), with few records from the winter precipitation-dominated western CA (WCA)...
• Neofunctionalization of an OMT cluster dominates polymethoxyflavone biosynthesis associated with the domestication of citrus AI翻译
  作者：Peng, Zhaoxin; Song, Lizhi; Chen, Minghua; Liu, Zeyang; Yuan, Ziyu; Wen, Huan; Zhang, Haipeng; Huang, Yue; Peng, Zhaowen; Yang, Hongbin; Li, Gu; Zhang, Huixian; Hu, Zhehui; Li, Wenyun; Wang, Xia; Larkin, Robert M.; Deng, Xiuxin; Xu, Qiang; Chen, Jiajing
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Henan Agricultural University; Guizhou Academy of Agricultural Sciences
  摘要：Polymethoxyflavones (PMFs) are a class of abundant specialized metabolites with remarkable anticancer properties in citrus. Multiple methoxy groups in PMFs are derived from methylation modification catalyzed by a series of hydroxylases and O- methyltransferases (OMTs). However, the specific OMTs that catalyze the systematic O- methylation of hydroxyflavones remain largely unknown. Here, we report that PMFs are highly accumulated in wild mandarins and mandarin- derived accessions, while undetec...
• Supramolecular coordination platinum metallacycle-based multilevel wound dressing for bacteria sensing and wound healing AI翻译
  作者：Li, Wen-Zhen; Wang, Xiao-Qiang; Liu, Ling-Ran; Xiao, Ju; Wang, Xin-Qiong; Ye, Yu-Yuan; Zhu, Mai-Yong; Sun, Yan; Stang, Peter J.; Sun, Yao
  作者单位：Wuhan University of Science & Technology; Henan University; Jiangsu University; Shanghai Jiao Tong University; Central China Normal University; Utah System of Higher Education; University of Utah
  摘要：The exploitation of novel wound healing methods with real - time infection sensing and high spatiotemporal precision is highly important for human health. Pt - based metal- organic cycles/cages (MOCs) have been employed as multifunctional antibacterial agents due to their superior Pt- related therapeutic efficiency, various functional subunits and specific geometries. However, how to rationally apply these nanoscale MOCs on the macroscale with controllable therapeutic output is still challengi...
• The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells AI翻译
  作者：Liang, Junyi; Seghiri, Mohamed; Singh, Pradeep Kumar; Seo, Hyeon Gyu; Lee, Ji Yeong; Jo, Yoonjung; Song, Yong Bhum; Park, Chulo; Zalicki, Piotr; Jeong, Jae- Yeon; Huh, Won-Ki; Caculitan, Nina G.; Smith, Adam W.
  作者单位：Cleveland Clinic Foundation; University System of Ohio; University of Akron; Texas Tech University System; Texas Tech University; Seoul National University (SNU); Seoul National University (SNU)
  摘要：While the existence and functional role of class C G- protein- coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C- X- C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we i...
• Biodiversity and productivity in eastern US forests AI翻译
  作者：Liu, Yunpeng; Lichstein, Jeremy W.; Guralnick, Robert P.; Soltis, Douglas E.; Soltis, Pamela S.; Scheiner, Samuel M.
  作者单位：Peking University; Peking University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; National Science Foundation (NSF)
  摘要：Despite experimental and observational studies demonstrating that biodiversity enhances primary productivity, the best metric for predicting productivity at broad geographic extents-functional trait diversity, phylogenetic diversity, or species richness-remains unknown. Using >1.8 million tree measurements from across eastern US forests, we quantified relationships among functional trait diversity, phylogenetic diversity, species richness, and productivity. Surprisingly, functional trait and p...