14期

最新文章

• Structural and electronic transformations of GeSe2 glass under high pressures studied by X-ray absorption spectroscopy AI翻译
  作者：Mijit, Emin; Durandurdu, Murat; Rodrigues, Joao Elias F. S.; Trapananti, Angela; Rezvani, S. Javad; Rosa, Angelika Dorothea; Mathon, Olivier; Irifune, Tetsuo; Di Cicco, Andrea
  作者单位：University of Camerino; European Synchrotron Radiation Facility (ESRF); Abdullah Gul University; Ehime University
  摘要：Pressure-induced transformations in an archetypal chalcogenide glass (GeSe2) have been investigated up to 157 GPa by X-ray absorption spectroscopy (XAS) and molecular dynamics (MD) simulations. Ge and Se K-edge XAS data allowed simultaneous tracking of the correlated local structural and electronic changes at both Ge and Se sites. Thanks to the simultaneous analysis of extended X-ray absorption fine structure (EXAFS) signals of both edges, reliable quantitative information about the evolution ...
• Localization of overdamped bosonic modes and transport in strange metals AI翻译
  作者：Patel, Aavishkar A.; Lunts, Peter; Sachdev, Subir
  作者单位：Simons Foundation; Flatiron Institute; Harvard University
  摘要：The strange metal phase of correlated electrons materials was described in a recent theory by a model of a Fermi surface coupled a two-dimensional quantum critical bosonic field with a spatially random Yukawa coupling. With the assumption of selfaveraging randomness, similar to that in the Sachdev-Ye-Kitaev model, numerous observed properties of a strange metal were obtained for a wide range of intermediate temperatures, including the linear in temperature resistivity. The Harris criterion imp...
• The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling AI翻译
  作者：Murthy, Divya; Attri, Kuldeep S.; Suresh, Voddu; Rajacharya, Girish H.; Valenzuela, Carlos A.; Thakur, Ravi; Zhao, Junzhang; Shukla, Surendra K.; V. Chaika, Nina; Labreck, Drew; V. Rao, Chinthalapally; Hollingsworth, Michael A.; Mehla, Kamiya; Singh, Pankaj K.
  作者单位：University of Nebraska System; University of Nebraska Medical Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center
  摘要：Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the role of MUC1, a mucin protein overexpressed in pancreatic cancer, in regulating polyamine metabolism. Utilizing pancreatic cancer patient data, we noted a positive correlation between MUC1 expression and the expression of key polyamine metabolism pathway genes. Functional studies r...
• Force- induced tail- autotomy mitochondrial fission and biogenesis of matrixexcluded mitochondrial- derived vesicles for quality control AI翻译
  作者：Liu, Xiaoying; Xu, Linyu; Song, Yutong; Zhao, Zhihao; Li, Xinyu; Wong, Cheuk - Yiu; Chen, Rong; Feng, Jianxiong; Gou, Yitao; Qi, Yajing; Chow, Hei-Man; Yao, Shuhuai; Wang, Yi; Gao, Song; Liu, Xingguo; Duan, Liting
  作者单位：Chinese University of Hong Kong; Hong Kong University of Science & Technology; Sun Yat Sen University; State Key Lab Oncology South China; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Hong Kong University of Science & Technology; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Guangzhou Medical University; Chinese Academy of Sciences
  摘要：Mitochondria constantly fuse and divide for mitochondrial inheritance and functions. Here, we identified a distinct type of naturally occurring fission, tail- autotomy fission, wherein a tail - like thin tubule protrudes from the mitochondrial body and disconnects, resembling autotomy. Next, utilizing an optogenetic mitochondria- specific mechanostimulator, we revealed that mechanical tensile force drives tail- autotomy fission. This force- induced fission involves DRP1/MFF and endoplasmic ret...
• Utilizing developmental dynamics for evolutionary prediction and control AI翻译
  作者：Milocco, Lisandro; Uller, Tobias
  作者单位：Lund University
  摘要：Understanding, predicting, and controlling the phenotypic consequences of genetic and environmental change is essential to many areas of fundamental and applied biology. In evolutionary biology, the generative process of development is a major source of organismal evolvability that constrains or facilitates adaptive change by shaping the distribution of phenotypic variation that selection can act upon. While the complex interactions between genetic and environmental factors during development ...
• Signal integration in chemoreceptor complexes AI翻译
  作者：Koler, Moriah; Parkinson, John S.; Vaknin, Ady
  作者单位：Hebrew University of Jerusalem; Utah System of Higher Education; University of Utah
  摘要：Motile bacteria use large receptor arrays to detect chemical and physical stimuli in their environment, process this complex information, and accordingly bias their swimming in a direction they deem favorable. The chemoreceptor molecules form tripod - like trimers of receptor dimers through direct contacts between their cytoplasmic tips. A pair of trimers, together with a dedicated kinase enzyme, form a core signaling complex. Hundreds of core complexes network to form extended arrays. While c...
• Elasticity and rheology of auxetic granular metamaterials AI翻译
  作者：Haver, Daan; Acuna, Daniel; Janbaz, Shahram; Lerner, Edan; During, Gustavo; Coulais, Corentin
  作者单位：University of Amsterdam; Universidad de Chile; Pontificia Universidad Catolica de Chile
  摘要：The flowing, jamming, and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: A granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson's ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection of auxetic grains based on a re-entrant mechanism and show that each grain exhibits a negative ...
• A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery AI翻译
  作者：Kim, Jihye; Bury, Matthew I.; Kwon, Kyeongha; Yoo, Jae - Young; Halstead, Nadia, V; Shin, Hee-Sup; Li, Shupeng; Won, Sang Min; Seo, Min-Ho; Wu, Yunyun; Park, Do Yun; Kini, Mitali; Kwak, Jean Won; Madhvapathy, Surabhi R.; Ciatti, Joanna L.; Lee, Jae Hee; Kim, Suyeon; Ryu, Hanjun; Yamagishi, Kento; Yoon, Hong- Joon; Kwak, Sung Soo; Kim, Bosung; Huang, Yonggang; Halliday, Lisa C.; Cheng, Earl Y.; Ameer, Guillermo A.; Sharma, Arun K.; Rogers, John A.
  作者单位：Northwestern University; Sungkyunkwan University (SKKU); Ann & Robert H. Lurie Children's Hospital of Chicago; Korea Advanced Institute of Science & Technology (KAIST); Sungkyunkwan University (SKKU); Northwestern University; Sungkyunkwan University (SKKU); Pusan National University; Northwestern University; Feinberg School of Medicine; Chung Ang University; Gachon University; Korea Institute of Science & Technology (KIST); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
  摘要：Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient - friendly, they exhibit user - to - user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter - associated urinary tract infections, which can progress to ascending pye...
• We need a solid scientific basis for nature- based climate solutions in the United States AI翻译
  作者：Novick, Kimberly A.; Keenan, Trevor F.; Anderegg, William R. L.; Normile, Caroline P.; Runkle, Benjamin R. K.; Oldfield, Emily E.; Shrestha, Gyami; Baldocchi, Dennis D.; Evans, Margaret E. K.; Randerson, James T.; Sanderman, Jonathan; Torn, Margaret S.; Trugman, Anna T.; Williams, Christopher A.
  作者单位：Indiana University System; Indiana University Bloomington; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; University of Arkansas System; University of Arkansas Fayetteville; Environmental Defense Fund; University of Arizona; University of California System; University of California Irvine; University of California System; University of California Berkeley; University of California System; University of California Santa Barbara; Clark University
• Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma AI翻译
  作者：Pires, Layla; Khattak, Shireen; Pratavieira, Sebastiao; Calcada, Carla; Romano, Renan; Yucel, Yeni; Bagnato, Vanderlei S.; Kurachi, Cristina; Wilson, Brian C.
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Universidade de Sao Paulo; University of Toronto; Saint Michaels Hospital Toronto; University of British Columbia; Texas A&M University System; Texas A&M University College Station; University of Toronto
  摘要：Photodynamic therapy (PDT) relies on a series of photophysical and photochemical reactions leading to cell death. While effective for various cancers, PDT has been less successful in treating pigmented melanoma due to high light absorption by melanin. Here, this limitation is addressed by 2- photon excitation of the photosensitizer (2p - PDT) using -100 fs pulses of near- infrared laser light. A critical role of melanin in enabling rather than hindering 2p - PDT is elucidated using pigmented a...