14期

最新文章

• Multi- axis fields boost SABRE hyperpolarization AI翻译
  作者：Lindale, Jacob R.; Smith, Loren L.; Mammen, Mathew W.; Eriksson, Shannon L.; Everhart, Lucas M.; Warren, Warren S.
  作者单位：Duke University; Duke University; Duke University; Duke University; Duke University
  摘要：The inherently low signal - to - noise ratio of NMR and MRI is now being addressed by hyperpolarization methods. For example, iridium - based catalysts that reversibly bind both parahydrogen and ligands in solution can hyperpolarize protons (SABRE) or heteronuclei (X- SABRE) on a wide variety of ligands, using a complex interplay of spin dynamics and chemical exchange processes, with common signal enhancements between 10(3 )and 10(4). This does not approach obvious theoretical limits, and furt...
• Phenotypic changes of auditory nerve fibers after excitotoxicity AI翻译
  作者：Diuba, Artem; Gratias, Paul; Jeffers, Penelope W. C.; Nouvian, Regis; Puel, Jean- Luc; Kujawa, Sharon G.; Bourien, Jerome
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard University; Universite de Montpellier; Harvard University; Harvard Medical School
  摘要：There is a substantial body of evidence elucidating the pathophysiological aspects of excitotoxicity in the mammalian cochlea. However, the question of whether the resultant damage is reversible remains unresolved. To replicate an excitotoxic event, we investigated the long- term effects of kainate application in gerbil cochleae. Surprisingly, despite persistent synapse loss, the compound action potential of the auditory nerve fully recovered. This functional retrieval was associated with a ph...
• Phase separation boosts HECT E3-mediated polyubiquitination AI翻译
  作者：Zhu, Kang; Li, Jingyu; Wen, Wenyu
  作者单位：Fudan University; Fudan University
• A red- emitting carborhodamine for monitoring and measuring membrane potential AI翻译
  作者：Gest, Anneliese M. M.; Lazzari-Dean, Julia R.; Ortiz, Gloria; Yaeger-Weiss, Susanna K.; Boggess, Steven C.; Miller, Evan W.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Biological membrane potentials, or voltages, are a central facet of cellular life. Optical methods to visualize cellular membrane voltages with fluorescent indicators are an attractive complement to traditional electrode - based approaches, since imaging methods can be high throughput, less invasive, and provide more spatial resolution than electrodes. Recently developed fluorescent indicators for voltage largely report changes in membrane voltage by monitoring voltage- dependent fluctuations ...
• Arctic amplification-induced decline in West and South Asia dust warrants stronger antidesertification toward carbon neutrality AI翻译
  作者：Wang, Fan; Yu, Yangyang; Patel, Piyushkumar N.; Gautam, Ritesh; Gao, Meng; Liu, Cheng; Ding, Yihui; Chen, Haishan; Yang, Yuanjian; Zhou, Yuyu; Carmichael, Gregory R.; McElroy, Michael B.
  作者单位：Hong Kong Baptist University; Harvard University; Texas A&M University System; Texas A&M University College Station; Environmental Defense Fund; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); United States Department of Energy (DOE); Oak Ridge National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Anhui Institute of Optics & Fine Mechanics (AIOFM), CAS; China Meteorological Administration; National Climate Centre, China Meteorological Administration; Nanjing University of Information Science & Technology; University of Hong Kong; University of Hong Kong; University of Iowa
  摘要：Dust loading in West and South Asia has been a major environmental issue due to its negative effects on air quality, food security, energy supply and public health, as well as on regional and global weather and climate. Yet a robust understanding of its recent changes and future projection remains unclear. On the basis of several high- quality remote sensing products, we detect a consistently decreasing trend of dust loading in West and South Asia over the last two decades. In contrast to prev...
• Elimination of virus- like particles reduces protein aggregation and extends replicative lifespan in Saccharomyces cerevisiae AI翻译
  作者：Schneider, K. L.; Hao, X.; Keuenhof, K. S.; Berglund, L. L.; Fischbach, A.; Ahmadpour, D.; Chawla, S.; Gomez, P.; Hoog, J. L.; Widlund, P. O.; Nystrom, T.
  作者单位：Cochlear; Max Planck Society; Sahlgrenska University Hospital; Chalmers University of Technology; Pompeu Fabra University; University of Gothenburg; University of Gothenburg
  摘要：A major consequence of aging and stress, in yeast to humans, is an increased accumulation of protein aggregates at distinct sites within the cells. Using genetic screens, immunoelectron microscopy, and three- dimensional modeling in our efforts to elucidate the importance of aggregate annexation, we found that most aggregates in yeast accumulate near the surface of mitochondria. Further, we show that virus - like particles (VLPs), which are part of the retrotransposition cycle of Ty elements, ...
• Synthesis of bioengineered heparin chemically and biologically similar to porcine- derived products and convertible to low MW heparin AI翻译
  作者：Douaisi, Marc; Paskaleva, Elena E.; Fu, Li; Grover, Navdeep; McManaman, Charity L.; Varghese, Sony; Brodfuehrer, Paul R.; Gibson, James M.; de Joode, Ian; Xia, Ke; Brier, Matthew I.; Simmons, Trevor J.; Datta, Payel; Zhang, Fuming; Onishi, Akihiro; Hirakane, Makoto; Mori, Daisuke; Linhardt, Robert J.; Dordick, Jonathan S.
  作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute
  摘要：Heparins have been invaluable therapeutic anticoagulant polysaccharides for over a century, whether used as unfractionated heparin or as low molecular weight heparin (LMWH) derivatives. However, heparin production by extraction from animal tissues presents multiple challenges, including the risk of adulteration, contamination, prion and viral impurities, limited supply, insecure supply chain, and significant batch - to - batch variability. The use of animal- derived heparin also raises ethical...
• Intimate contact between red blood cells and vessel walls is sufficient to stabilize capillary networks during development AI翻译
  作者：Lorthois, Sylvie
  作者单位：Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Centre National de la Recherche Scientifique (CNRS)
• Reply to Eichbichler et al.: Phase separation boosts HECT E3-mediated polyubiquitination AI翻译
  作者：Zhu, Kang; Li, Jingyu; Wen, Wenyu
  作者单位：Fudan University; Fudan University
• Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM2.5 components AI翻译
  作者：Song, Yuanyuan; Zhang, Yanhao; Zhu, Lin; Chen, Yanyan; Chen, Yi-Jie; Zhu, Zhitong; Feng, Jieqing; Qi, Zenghua; Yu, Jian Zhen; Yang, Zhu; Cai, Zongwei
  作者单位：Hong Kong Baptist University; Guangdong University of Technology; Hong Kong University of Science & Technology; Hong Kong Baptist University
  摘要：Fine particulate matter (PM2.5) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM2.5 components to its toxicity, especially considering regional disparities. Moreover, prevention solutions for PM2.5- associated health effects are scarce. In the present study, we comprehensively characterized and compared the primary PM2.5 constituents and their altered metabolites from two locations: Taiyuan and Guangzhou. Anal...