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作者：Seas, Andreas; Noor, M. Sohail; Choi, Ki Sueng; Veerakumar, Ashan; Obatusin, Mosadoluwa; Dahill-Fuchel, Jacob; Tiruvadi, Vineet; Xu, Elisa; Riva-Posse, Patricio; Rozell, Christopher J.; Mayberg, Helen S.; Mcintyre, Cameron C.; Waters, Allison C.; Howell, Bryan
作者单位：Duke University; Duke University; University System of Ohio; Case Western Reserve University; Icahn School of Medicine at Mount Sinai; Emory University; University System of Georgia; Georgia Institute of Technology
摘要：Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for responsible for driving this response. Individualized biophysical models were built to achieve selective engagement of two target bundles: either the forceps minor (FM) or cingulum bundle (CB). Unilateral 2 Hz stimulation was performed in seven patients with treatment- resistant depression who responded to SCC DBS, and EPs were recorded using 256- sensor scalp electroencephalography. Two distinct EPs were obser...
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作者：Kim, Hong Ji; Lux, Byeol Kim; Lee, Eunjin; Finn, Emily S.; Woo, Choong- Wan
作者单位：Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Dartmouth College
摘要：The contents and dynamics of spontaneous thought are important factors for personality traits and mental health. However, assessing spontaneous thoughts is challenging due to their unconstrained nature, and directing participants' attention to report their thoughts may fundamentally alter them. Here, we aimed to decode two key content dimensions of spontaneous thought-self- relevance and valence-directly from brain activity. To train functional MRI-based predictive models, we used individually...
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作者：Long, Benedict Michael; Matsuda, Yusuke; Moroney, James V.
作者单位：University of Newcastle; Kwansei Gakuin University; Louisiana State University System; Louisiana State University
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作者：Mantilla, Alexander B. C.; Wang, Chih-Feng; Krayev, Andrey; Gu, Yi; Schultz, Zachary D.; El-Khoury, Patrick Z.
作者单位：Washington State University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University System of Ohio; Ohio State University
摘要：Chemical transformations near plasmonic metals have attracted increasing attention in the past few years. Specifically, reactions occurring within plasmonic nanojunctions that can be detected via surface and tip- enhanced Raman (SER and TER) scattering were the focus of numerous reports. In this context, even though the transition between localized and nonlocal (quantum) plasmons at nanojunctions is documented, its implications on plasmonic chemistry remain poorly understood. We explore the la...
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作者：Mao, Li; Quan, Zhuo; Liu, Zhi- Sheng; Huang, Chun- Hua; Wang, Zi- Han; Tang, Tian- Shu; Li, Pei- Lin; Shao, Jie; Liu, Ya- Jun; Zhu, Ben- Zhan
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing Normal University; Beijing Normal University; Beijing University of Chemical Technology
摘要：It is well-known that highly reactive hydroxyl radicals (HO center dot) can be produced by the classic Fenton system and our recently discovered haloquinone/H2O2 system, but rarely from thiol- derivatives. Here, we found, unexpectedly, that HO center dot can be generated from H2O2 and thiourea dioxide (TUO2), a widely used and environmentally friendly bleaching agent. A carbon- centered radical and sulfite were detected and identified as the transient intermediates, and urea and sulfate as the...
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作者：Su, Zhengping; Duan, Yu; Tian, Yusong; Guo, Shukuan; Li, Penghui; Wang, Lin; Bu, Yeqiang; Nie, Anmin; Wang, Hongtao; Tian, Yongjun; Yang, Wei
作者单位：Zhejiang University; Suzhou Laboratory; Zhejiang University; Yanshan University
摘要：The structure of dislocation cores, the fundamental knowledge on crystal plasticity, remains largely unexplored in covalent crystals. Here, we conducted atomically resolved characterizations of dislocation core structures in a plastically deformed diamond anvil cell tip that was unloaded from an exceptionally high pressure of 360 GPa. Our observations unveiled a series of nonequilibrium dislocation cores that deviate from the commonly accepted five- seven- membered ring dislocation core model ...
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作者：Karnaukhov, Vadim K.; Gac, Anne- Laure Le; Mutala, Linda Bilonda; Darbois, Aurelie; Perrin, Laetitia; Legoux, Francois; Walczak, Aleksandra M.; Mora, Thierry; Lantz, Olivier
作者单位：Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Rennes; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：How T- cell receptor (TCR) characteristics determine subset commitment during T- cell development is still unclear. Here, we addressed this question for innate- like T cells, mucosal- associated invariant T (MAIT) cells, and invariant natural killer T (iNKT) cells. MAIT and iNKT cells have similar developmental paths, leading in mice to two effector subsets, cytotoxic (MAIT1/iNKT1) and IL17- secreting (MAIT17/iNKT17). For iNKT1 vs iNKT17 fate choice, an instructive role for TCR affinity was pr...
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作者：Greene, Patrick; Bastian, Amy J.; Schieber, Marc H.; Sarma, Sridevi, V
作者单位：Johns Hopkins University; Kennedy Krieger Institute; Johns Hopkins University; University of Rochester; Johns Hopkins University
摘要：Optimal feedback control provides an abstract framework describing the architecture of the sensorimotor system without prescribing implementation details such as what coordinate system to use, how feedback is incorporated, or how to accommodate changing task complexity. We investigate how such details are determined by computational and physical constraints by creating a model of the upper limb sensorimotor system in which all connection weights between neurons, feedback, and muscles are unkno...
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作者：Lee, Ki Won; Ryu, Ki-jun; Kim, Minju; Lim, Seyeon; Kim, Jisu; Kim, Jeong Yoon; Hwangbo, Cheol; Yoo, Jiyun; Cho, Yong-Yeon; Kim, Kwang Dong
作者单位：Gyeongsang National University; Gyeongsang National University; Gyeongsang National University; Gyeongsang National University; Gyeongsang National University; Catholic University of Korea; Gyeongsang National University
摘要：Melanosomes are specific organelles dedicated to melanin synthesis and accumulation in melanocytes. Autophagy is suggestively involved in melanosome degradation, although the potential underlying molecular mechanisms remain elusive. In selective autophagy, autophagy receptors and E3- ligases are the key factors conferring cargo selectivity. In B16F10 cells, (3- mangostin efficiently induced melanosome degradation without affecting other organelles such as mitochondria, peroxisomes, and the end...
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作者：Slominski, Radomir M.; Chen, Jake Y.; Raman, Chander; Slominski, Andrzej T.
作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; US Department of Veterans Affairs; Veterans Health Administration (VHA)
摘要：we have gathered experimental and obser- vational evidence that UVR spectra of solar radiation have profound effects on systemic body homeostasis, which are defined by their wavelength and energy, nature of chromo- phores and of molecules produced in the barrier organ. Local physicochemical changes induced by solar radiation can lead to activation of local neuro- immuno- endocrine sensing and regulatory mechanisms with their projection to the central or systemic levels. While the precise mecha...
