14期

最新文章

• Automating the analysis of facial emotion expression dynamics: A computational framework and application in psychotic disorders AI翻译
  作者：Hall, Nathan T.; Hallquist, Michael N.; Martin, Elizabeth A.; Lian, Wenxuan; Jonas, Katherine G.; Kotov, Roman
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California Irvine; State University of New York (SUNY) System; Stony Brook University
  摘要：Facial emotion expressions play a central role in interpersonal interactions; these displays are used to predict and influence the behavior of others. Despite their importance, quantifying and analyzing the dynamics of brief facial emotion expressions remains an understudied methodological challenge. Here, we present a method that leverages machine learning and network modeling to assess the dynamics of facial expressions. Using video recordings of clinical interviews, we demonstrate the utili...
• Geometric design of antireflective leafhopper brochosomes AI翻译
  作者：Wang, Lin; Li, Zhuo; Shen, Sheng; Wong, Tak-Sing
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：In nature, leafhoppers cover their body surfaces with brochosomes as a protective coating. These leafhopper- produced brochosomes are hollow, buckyball- shaped, nanoscopic spheroids with through - holes distributed across their surfaces, representing a class of deployable optical materials that are rare in nature. Despite their discovery in the 1950s, it remains unknown why the sizes of brochosomes and their through - holes consistently fall within the range of hundreds of nanometers across di...
• Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response AI翻译
  作者：Yan, Yahui; Shetty, Maithili; Harding, Heather P.; George, Ginto; Zyryanova, Alisa; Labbe, Katherine; Mafi, Amirhossein; Hao, Qi; Sidrauski, Carmela; Ron, David; Hinnebusch, Alan
  作者单位：University of Cambridge
  摘要：Dephosphorylation of pSer51 of the alpha subunit of translation initiation factor 2 (eIF2 alpha P) terminates signaling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a protein phosphatase 1 (PP1) catalytic subunit, the conserved C- terminally located -70 amino acid core of a substrate- specific regulatory subunit (PPP1R15A/GADD34 or PPP1R15B/CReP) and G - actin (an essential cofactor) efficiently dephosphorylate eIF2 alpha P in vitro. Unlike their v...
• Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis- infected rabbits AI翻译
  作者：Datta, Meenal; Via, Laura E.; Dartois, Veronique; Weiner, Danielle M.; Zimmerman, Matthew; Kaya, Firat; Walker, April M.; Fleegle, Joel D.; Raplee, Isaac D.; Mcninch, Colton; Zarodniuk, Maksym; Kamoun, Walid S.; Yue, Changli; Kumar, Ashwin S.; Subudhi, Sonu; Xu, Lei; Barry, Clifton E.; Jain, Rakesh K.
  作者单位：Capital Medical University; University of Notre Dame; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Division of Intramural Research (DIR); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
  摘要：Host- directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno- modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing and normalizing the aberrant granuloma- associated vasculature, here we demonstrate that FDA- approved therapies (bevacizumab and losartan, respectiv...
• Intelligent electroactive material systems with self- adaptive mechanical memory and sequential logic AI翻译
  作者：El Helou, Charles; Hyatt, Lance P.; Buskohl, Philip R.; Harne, Ryan L.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Defense; United States Air Force; US Air Force Research Laboratory
  摘要：By synthesizing the requisite functionalities of intelligence in an integrated material system, it may become possible to animate otherwise inanimate matter. A significant challenge in this vision is to continually sense, process, and memorize information in a decentralized way. Here, we introduce an approach that enables all such functionalities in a soft mechanical material system. By integrating nonvolatile memory with continuous processing, we develop a sequential logic - based material de...
• Chemical bonding dictates drastic critical temperature difference in two seemingly identical superconductors AI翻译
  作者：Lavroff, Robert H.; Munarriz, Julen; Dickerson, Claire E.; Munoz, Francisco; Alexandrova, Anastassia N.
  作者单位：University of California System; University of California Los Angeles; University of Zaragoza; University of Zaragoza; Universidad de Chile; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Though YB6 and LaB6 share the same crystal structure, atomic valence electron configuration, and phonon modes, they exhibit drastically different phonon- mediated superconductivity. YB6 superconducts below 8.4 K, giving it the second- highest critical temperature of known borides, second only to MgB2. LaB6 does not superconduct until near- absolute zero temperatures (below 0.45 K), however. Though previous studies have quantified the canonical superconductivity descriptors of YB6's greater Fer...
• Premeiotic pairing of homologous chromosomes during Drosophila male meiosis (vol 119, e2207660119, 2022) AI翻译
  作者：Rubin, Thomas; Macaisne, Nicolas; Valles, Ana Maria; Guilleman, Clara; Gaugue, Isabelle; Dal Toe, Laurine; Huynh, Jean- Rene
• Dynamic imaging of force chains in 3D granular media AI翻译
  作者：Li, Wei; Juanes, Ruben
  作者单位：Massachusetts Institute of Technology (MIT); State University of New York (SUNY) System; Stony Brook University
  摘要：Granular media constitute the most abundant form of solid matter on Earth and beyond. When external forces are applied to a granular medium, the forces are transmitted through it via chains of contacts among grains-force chains. Understanding the spatial structure and temporal evolution of force chains constitutes a fundamental goal of granular mechanics. Here, we introduce an experimental technique, interference optical projection tomography, to study force chains in threedimensional (3D) gra...
• Trimethylamine-N-oxide depletes urea in a peptide solvation shell AI翻译
  作者：Nasralla, Mazin; Laurent, Harrison; Alderman, Oliver L. G.; Headen, Thomas F.; Dougan, Lorna
  作者单位：University of Leeds; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory
  摘要：Trimethylamine-N-oxide (TMAO) and urea are metabolites that are used by some marine animals to maintain their cell volume in a saline environment. Urea is a well-known denaturant, and TMAO is a protective osmolyte that counteracts ureainduced protein denaturation. TMAO also has a general protein-protective effect, for example, it counters pressure-induced protein denaturation in deep -sea fish. These opposing effects on protein stability have been linked to the spatial relationship of TMAO, ur...
• Highly efficient electrocatalytic CO2 reduction by a CrIII quaterpyridine complex AI翻译
  作者：Wang, Jia- Wei; Luo, Zhi- Mei; Yang, Guangjun; Gil-Sepulcre, Marcos; Kupfer, Stephan; Ruediger, Olaf; Ouyang, Gangfeng
  作者单位：Sun Yat Sen University; Friedrich Schiller University of Jena; Max Planck Society
  摘要：Design tactics and mechanistic studies both remain as fundamental challenges during the exploitations of earth- abundant molecular electrocatalysts for CO2 reduction, especially for the rarely studied Cr-based ones. Herein, a quaterpyridyl Cr-III catalyst is found to be highly active for CO2 electroreduction to CO with 99.8% Faradaic efficiency in DMF/phenol medium. A nearly one order of magnitude higher turnover frequency (86.6 s(-1)) over the documented Cr- based catalysts (<10 s(-1)) can be...