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作者：Jansen, Nico A.; Cestele, Sandrine; Marco, Silvia Sanchez; Schenke, Maarten; Stewart, Kirsty; Patel, Jayesh; Tolner, Else A.; Brunklaus, Andreas; Mantegazza, Massimo; van den Maagdenberg, Arn M. J. M.
作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Universite Cote d'Azur; Universite Cote d'Azur; University of Bristol; Bristol Royal Hospital For Children; Queen Elizabeth University Hospital (QEUH); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Glasgow; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur
摘要：Apneic events are frightening but largely benign events that often occur in infants. Here, we report apparent life- threatening apneic events in an infant with the homozygous SCN1AL263V missense mutation, which causes familial hemiplegic migraine type 3 in heterozygous family members, in the absence of epilepsy. Observations consistent with the events in the infant were made in an Scn1aL263V knock - in mouse model, in which apnea was preceded by a large brainstem DC-shift, indicative of profou...
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作者：Eichbichler, Daniela; Bernecker, Christine; Stengel, Florian; Scheffner, Martin
作者单位：University of Konstanz
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作者：Fu, Xinlong; He, Feng; Liu, Xin; Ge, Binghui; Zhang, Deyi; Chang, Qian; Gao, Jingchi; Li, Xiaodong; Huang, Changshui; Li, Yuliang
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Harbin Institute of Technology; Anhui University
摘要：A concept of solar energy convertible zinc-air battery (SZAB) is demonstrated through rational design of an electrode coupled with multifunction. The multifunctional electrode is fabricated using nitrogen- substituted graphdiyne (N-GDY) with large pi-conjugated carbonous network, which can work as photoresponsive bifunctional electrocatalyst, enabling a sunlight- promoted process through efficient injection of photoelectrons into the conduction band of N-GDY. SZAB enables direct conversion and...
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作者：Wu, Ruixin; Sun, Chunming; Chen, Xi; Yang, Runyue; Luan, Yuxuan; Zhao, Xiang; Yu, Panpan; Luo, Rongkui; Hou, Yingyong; Tian, Ruotong; Bian, Shasha; Li, Yuli; Dong, Yinghua; Liu, Qian; Dai, Weiwei; Fan, Zhuoyang; Yan, Rucheng; Pan, Binyang; Feng, Siheng; Wu, Jing; Chen, Fangzhen; Yang, Changle; Wang, Hanlin; Dai, Haochen; Shu, Minfeng
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Dalian Medical University
摘要：Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5- methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains unclear, as does the contribution of m5C- modified RNA to the glioma immune microenvironment. In this study, we demonstrate that the canonical 28SrRNA methyltransferase NSUN5 down- regulates (3- catenin by promoting the degradation of its m...
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作者：He, Yu-Juan; Lu, Gang; Xu, Bo-Jie; Mao, Qian-Zhuo; Qi, Yu-Hua; Jiao, Gao-Yang; Weng, Hai-Tao; Tian, Yan-Zhen; Huang, Hai-Jian; Zhang, Chuan-Xi; Chen, Jian-Ping; Li, Jun-Min
作者单位：Ningbo University; Ningbo University
摘要：Throughout evolution, arboviruses have developed various strategies to counteract the host's innate immune defenses to maintain persistent transmission. Recent studies have shown that, in addition to bacteria and fungi, the innate Toll-Dorsal immune system also plays an essential role in preventing viral infections in invertebrates. However, whether the classical Toll immune pathway is involved in maintaining the homeostatic process to ensure the persistent and propagative transmission of arbo...
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作者：Lal, Apoorv; You, Fengqi
作者单位：Cornell University; Cornell University
摘要：Climate change persists as a pressing global issue due to high greenhouse gas emissions from fossil fuel-based energy sources. A transition to a greener energy matrix combined with carbon offsetting is imperative to mitigate the rate at which global temperature ascends. While countries have deployed faith in green hydrogen to accelerate worldwide decarbonization efforts, the concurrent rise of blockchain- operated crypto- applications, such as bitcoin, has exacerbated climate change concerns. ...
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作者：Liu, Yixin; Wang, Ya-Jun; Du, Yang; Liu, Wei; Huang, Xuedong; Fan, Zihui; Lu, Jiayin; Yi, Runqiu; Xiang, Xiao-Wei; Xia, Xinwei; Gu, Hongzhou; Liu, Yan-Jun; Liu, Baohong
作者单位：Fudan University
摘要：Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to- amoeboid transition (MAT). However, the energy states in distinct migration modes, especially amoeboid-like stable bleb (A2) movement, remain unclear. In this report, we developed multivalent DNA framework-based nanomachines to explore strategical mitochondrial trafficking and differential ATP levels du...
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作者：Ravenscraft, Alison; Hunter, Martha S.
作者单位：University of Texas System; University of Texas Arlington; University of Arizona
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作者：Zenga, Jialiu; Loia, Gavin Wen Zhao; Saipuljumria, Eka Norfaishanty; Duranc, Marco Antonio Romero; Silva-Garciac, Octavio; Aguilard, Jose Manuel Perez-; Baizabal-Aguirrec, Victor M.; Loa, Chih Hung
作者单位：Nanyang Technological University; Universidad Michoacana de San Nicolas de Hidalgo
摘要：Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting receptor conformational dynamics is a viable strategy to modulate TNFR1 signaling. Here, we used a combination of biophysical, biochemical, and cellular assays, as well as molecular dynamics simulation ...
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作者：Paul, Indrajit; Konieczny, Krzysztof A.; Chavez, Roberto; Garcia-Garibay, Miguel A.
作者单位：University of California System; University of California Los Angeles
摘要：Photochemical valence bond isomerization of a crystalline Dewar benzene (DB) diacid monoanion salt with an acetophenone-linked piperazinium cation that serves as an intramolecular triplet energy sensitizer (DB- AcPh-Pz) exhibits a quantum chain reaction with as many as 450 product molecules per photon absorbed (Phi = 450). By contrast, isomorphous crystals of the DB diacid monosalt of an ethylbenzene- linked piperazinium (DB- EtPh-Pz) lacking a triplet sensitizer showed a less impressive quant...
