14期

最新文章

• Causal connectivity measures for pulse-output network reconstruction: Analysis and applications AI翻译
  作者：Tian, Zhong-qi K.; Chen, Kai; Li, Songting; Mclaughlind, David W.; Zhou, Douglas
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; New York University; New York University; New York University; NYU Shanghai; New York University; Shanghai Jiao Tong University
  摘要：The causal connectivity of a network is often inferred to understand network function. It is arguably acknowledged that the inferred causal connectivity relies on the causality measure one applies, and it may differ from the network's underlying structural connectivity. However, the interpretation of causal connectivity remains to be fully clarified, in particular, how causal connectivity depends on causality measures and how causal connectivity relates to structural connectivity. Here, we foc...
• Causal functional maps of brain rhythms in working memory AI翻译
  作者：Wischnewski, Miles; Berger, Taylor A.; Opitz, Alexander; Alekseichuk, Ivan
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Groningen
  摘要：Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in health...
• Ab initio generalized Langevin equation AI翻译
  作者：Xie, Pinchen; Car, Roberto; Weinan, E.
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University; Peking University; Peking University
  摘要：We introduce a machine learning-based approach called ab initio generalized Langevin equation (AIGLE) to model the dynamics of slow collective variables (CVs) in materials and molecules. In this scheme, the parameters are learned from atomistic simulations based on ab initio quantum mechanical models. Force field, memory kernel, and noise generator are constructed in the context of the Mori-Zwanzig formalism, under the constraint of the fluctuation-dissipation theorem. Combined with deep poten...
• March of the proviruses AI翻译
  作者：Barth, Zachary K.; Aylward, Frank O.
  作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
• The Titanic question in TB control: Should we worry about the bummock? AI翻译
  作者：Fortune, Sarah M.
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health
• Defining T cell receptor repertoires using nanovial-based binding and functional screening AI翻译
  作者：Koo, Doyeon; Mao, Zhiyuan; Dimatteo, Robert; Noguchi, Miyako; Tsubamoto, Natalie; McLaughlin, Jami; Tran, Wendy; Lee, Sohyung; Cheng, Donghui; de Rutte, Joseph; Sojo, Giselle Burton; Witte, Owen N.; Di Carlo, Dino
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
  摘要：The ability to selectively bind to antigenic peptides and secrete effector molecules can define rare and low- affinity populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage cavity- containing hydrogel microparticles, called nanovials, each coated with peptide - major histocompatibility complex (pMHC) monomers to isolate antigen- reactive T cells. T cells are captured and activated by pMHCs inducing the secretion of effector molecules inc...
• Ligand- induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit AI翻译
  作者：Stenstroem, Olof; Diehl, Carl; Modig, Kristofer; Akke, Mikael
  作者单位：Lund University
  摘要：Protein-ligand complex formation is fundamental to biological function. A central question is whether proteins spontaneously adopt binding- competent conformations to which ligands bind conformational selection (CS) or whether ligands induce the binding- competent conformation induced fit (IF). Here, we resolve the CS and IF binding pathways by characterizing protein conformational dynamics over a wide range of ligand concentrations using NMR relaxation dispersion. We determined the relative f...
• Costs of being a diet generalist for the protist predator Dictyostelium discoideum AI翻译
  作者：Shreenidhia, P. M.; Brocka, Debra A.; Mccabea, Rachel I.; Strassmanna, Joan E.; Quellera, David C.
  作者单位：Washington University (WUSTL)
  摘要：Consumers range from specialists that feed on few resources to generalists that feed on many. Generalism has the clear advantage of having more resources to exploit, but the costs that limit generalism are less clear. We explore two understudied costs of gener alism in a generalist amoeba predator, Dictyostelium discoideum, feeding on naturally co- occurring bacterial prey. Both involve costs of combining prey that are suitable on their own. First, amoebas exhibit a reduction in growth rate wh...
• Heterogeneous osteoimmune profiles via single-cell transcriptomics in osteoporotic patients who fail bisphosphonate treatment (vol 121, e2316871121, 2024) AI翻译
  作者：Keum, Byeong-Rak; Kim, Hong Jin; Lee, Juhun; Lee, Minji; Hong, Sin-Hyoung; Chang, Ha Kyun; Han, Jin-Kwan; Kim, Sanguk; Chang, Dong-Gune; Kim, Gun-Hwa
• The electrochemistry of stable sulfur isotopes versus lithium AI翻译
  作者：Li, Xue-Ting; Zhao, Yao; Zhu, Yu-Hui; Wang, Wen-Peng; Zhang, Ying; Wang, Fuyi; Guo, Yu-Guo; Xin, Sen; Bai, Chunli
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS
  摘要：Sulfur in nature consists of two abundant stable isotopes, with two more neutrons in the heavy one (S-34) than in the light one (S-32). The two isotopes show similar physicochemical properties and are usually considered an integral system for chemical research in various fields. In this work, a model study based on a Li-S battery was performed to reveal the variation between the electrochemical properties of the two S isotopes. Provided with the same octatomic ring structure, the cyclo-(34)S8 ...