17期

最新文章

• Contribution of microscopy to a better understanding of the anatomy of pathogenic protists AI翻译
  作者：de Souza, Wanderley
  作者单位：Universidade do Estado do Amazonas
  摘要：In this Inaugural Article the author briefly revises its scientific career and how he starts to work with parasitic protozoa. Emphasis is given to his contribution to topics such as a) the structural organization of the surface of protozoa using freeze - fracture and deep - etching; b) the cytoskeleton of protozoa, especially structures such as the subpellicular microtubules of trypanosomatids, the conoid of Toxoplasma gondii , microtubules and inner membrane complex of this protozoan, and the...
• Impacts of fire and prospects for recovery in a tropical peat forest ecosystem AI翻译
  作者：Harrison, Mark E.; Deere, Nicolas J.; Imron, Muhammad Ali; Nasir, Darmae; Adul; Asti, Hastin Ambar; Soler, Joana Aragay; Boyd, Nicholas C.; Cheyne, Susan M.; Collins, Sarah A.; D'Arcy, Laura J.; Erb, Wendy M.; Green, Hannah; Healy, William; Hendri; Holly, Brendan; Houlihan, Peter R.; Husson, Simon J.; Iwan; Jeffers, Karen A.; Kulu, Ici P.; Kusin, Kitso; Marchant, Nicholas C.; Morrogh-Bernard, Helen C.; Page, Susan E.; Purwanto, Ari; Capilla, Bernat Ripoll; Ortega, Oscar Rodriguez de Rivera; Santiano; Spencer, Katie L.; Sugardjito, Jito; Supriatna, Jatna; Thornton, Sara A.; van Veen, F. J. Frank; Yulintine; Struebig, Matthew J.
  作者单位：University of Exeter; University of Leicester; University of Kent; Gadjah Mada University; Universitas Palangka Raya (UPR); University of Oxford; Aberystwyth University; Oxford Brookes University; University of Plymouth; Cornell University; University of California System; University of California Los Angeles; University of Exeter; Universitas Nasional Pionir Perubahan; Universitas Nasional Pionir Perubahan; University of Indonesia; University of Exeter
  摘要：Uncontrolled fires place considerable burdens on forest ecosystems, compromising our ability to meet conservation and restoration goals. A poor understanding of the impacts of fire on ecosystems and their biodiversity exacerbates this challenge, particularly in tropical regions where few studies have applied consistent analytical techniques to examine a broad range of ecological impacts over multiyear time frames. We compiled 16 y of data on ecosystem properties (17 variables) and biodiversity...
• Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses AI翻译
  作者：Metwally, Hozaifa; Elbrashy, Maha M.; Ozawa, Tatsuhiko; Okuyama, Kazuki; White, Jason T.; Tulyeu, Janyerkye; Sondergaard, Jonas Norskov; Wing, James Badger; Muratsu, Arisa; Matsumoto, Hisatake; Ikawa, Masahito; Kishi, Hiroyuki; Taniuchi, Ichiro; Kishimoto, Tadamitsu
  作者单位：University of Osaka; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); University of Toyama; RIKEN; University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka
  摘要：Since its discovery over three decades ago, signal transducer and activator of scription 1 (STAT1) has been extensively studied as a central mediator for interferons (IFNs) signaling and antiviral defense. Here, using genetic and biochemical assays, we unveil Thr 748 as a conserved IFN - independent phosphorylation switch in Stat1, which restricts IFN signaling and promotes innate inflammatory responses following the recognition of the bacterial - derived toxin lipopolysaccharide (LPS). Geneti...
• Profile of Wanderley de Souza AI翻译
  作者：Viegas, Jennifer
• Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex AI翻译
  作者：Nguyen, Duc Minh; Rath, Deanna H.; Devost, Dominic; Petrin, Darlaine; Rizk, Robert; Ji, Alan X.; Narayanan, Naveen; Yong, Darren; Zhai, Andrew; Kuntz, Douglas A.; Mian, Maha U. Q.; Pomroy, Neil C.; Keszei, Alexander F. A.; Benlekbir, Samir; Mazhab-Jafari, Mohammad T.; Rubinstein, John L.; Hebert, Terence E.; Prive, Gilbert G.
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; McGill University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto
  摘要：Heterotrimeric G proteins can be regulated by posttranslational modifications, including ubiquitylation. KCTD5, a pentameric substrate receptor protein consisting of an N-terminal BTB domain and a C-terminal domain, engages CUL3 to form the central scaffold of a cullin-RING E3 ligase complex (CRL3(KCTD5)) that ubiquitylates G beta gamma and reduces G beta gamma protein levels in cells. The cryo-EM structure of a 5:5:5 KCTD5/CUL3(NTD)/G beta(1)gamma(2) assembly reveals a highly dynamic complex ...
• Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix AI翻译
  作者：Bellone, Stefania; Jeong, Kyungjo; Halle, Mari Kylleso; Krakstad, Camilla; Mcnamara, Blair; Greenman, Michelle; Mutlu, Levent; Demirkiran, Cem; Hartwich, Tobias Max Philipp; Yang-Hartwich, Yang; Zipponi, Margherita; Buza, Natalia; Hui, Pei; Raspagliesi, Francesco; Lopez, Salvatore; Paolini, Biagio; Milione, Massimo; Perrone, Emanuele; Scambia, Giovanni; Altwerger, Gary; Ravaggi, Antonella; Bignotti, Eliana; Huang, Gloria S.; Andikyan, Vaagn; Clark, Mitchell; Ratner, Elena; Azodi, Masoud; Schwartz, Peter E.; Quick, Charles M.; Angioli, Roberto; Terranova, Corrado; Zaidi, Samir; Nandi, Shuvro; Alexandrov, Ludmil B.; Siegel, Eric R.; Choi, Jungmin; Schlessinger, Joseph; Santin, Alessandro D.
  作者单位：Yale University; Korea University; Korea University Medicine (KU Medicine); University of Bergen; University of Bergen; Haukeland University Hospital; Yale University; Fondazione IRCCS Istituto Nazionale Tumori Milan; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Hospital Spedali Civili Brescia; University of Brescia; University of Arkansas System; University of Arkansas Medical Sciences; University Campus Bio-Medico - Rome Italy; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Diego; University of Arkansas System; University of Arkansas Medical Sciences; Yale University; IRCCS Istituto Tumori Bari Giovanni Paolo II
  摘要：High- grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole- exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the tumors. Recurrent WDFY3, a gene not yet implicated in NETc. Somatic CNV analysis identified two copy number gains (3q27.1 and 19q13.12) and five copy number losses (1p36.21/5q31.3/6p 22.2/9q21.11/11p15.5). Also, gene fusions affecting the ACLY- CRHR1 and PVT1- MYC gene...
• Gentrification drives patterns of alpha and beta diversity in cities AI翻译
  作者：Fidino, Mason; Sander, Heather A.; Lewis, Jesse S.; Lehrer, Elizabeth W.; Rivera, Kimberly; Murray, Maureen H.; Adams, Henry C.; Kase, Anna; Flores, Andrea; Stankowich, Theodore; Schell, Christopher J.; Salsbury, Carmen M.; Rohnke, Adam T.; Jordan, Mark J.; Green, Austin M.; Gramza, Ashley R.; Zellmer, Amanda J.; Williamson, Jacque; Surasinghe, Thilina D.; Storm, Hunter; Sparks, Kimberly L.; Ryan, Travis J.; Remine, Katie R.; Pendergast, Mary E.; Mullen, Kayleigh; Minier, Darren E.; Middaugh, Christopher R.; Mertl, Amy L.; Mcclung, Maureen R.; Long, Robert A.; Larson, Rachel N.; Kohl, Michel T.; Harris, Lavendar R.; Hall, Courtney T.; Haight, Jeffrey D.; Drake, David; Davidge, Alyssa M.; Cheek, Ann O.; Bloch, Christopher P.; Biro, Elizabeth G.; Anthonysamy, Whitney J. B.; Angstmann, Julia L.; Allen, Maximilian L.; Adalsteinsson, Solny A.; Gianotti, Anne G. Short; Lamontagne, Jalene M.; Candusso, Tiziana A. Gelmi; Magle, Seth B.
  作者单位：University of Iowa; Arizona State University; California State University System; California State University Long Beach; University of California System; University of California Berkeley; Butler University; Mississippi State University; Seattle University; Utah System of Higher Education; University of Utah; Occidental College; Massachusetts System of Public Higher Education; Bridgewater State University; Portland State University; Lesley University; University System of Georgia; University of Georgia; Arizona State University; Arizona State University-Tempe; University of Wisconsin System; University of Wisconsin Madison; University of Colorado System; University of Colorado Denver; University of Houston System; University of Houston; Washington University (WUSTL); University of Health Sciences & Pharmacy in St. Louis; Butler University; University of Illinois System; University of Illinois Urbana-Champaign; Illinois Natural History Survey; Boston University; DePaul University; University of Toronto
  摘要：While there is increasing recognition that social processes in cities like gentrification have ecological consequences, we lack nuanced understanding of the ways gentrification affects urban biodiversity. We analyzed a large camera trap dataset of mammals (>500 g) to evaluate how gentrification impacts species richness and community composition across 23 US cities. After controlling for the negative effect of impervious cover, gentrified parts of cities had the highest mammal species richness....
• Isotopes prove advanced, integral crop production, and stockbreeding strategies nourished Trypillia mega- populations (vol 120, e2312962120,2023) AI翻译
  作者：Schluetz, Frank; Hofmann, Robert; Dal Corso, Marta; Pashkevych, Galyna; Dreibrodt, Stefan; Shatilo, Mila; Terna, Andreea; Fuchs, Katharina; Filipovic, Dragana; Flohr, Pascal; Makarewicz, Cheryl A.; Terna, Stanislav; Videiko, Mykhailo; Rud, Vitalii; Mueller, Johannes; Kirleis, Wiebke
  作者单位：University of Kiel; University of Kiel; University of Padua; National Academy of Sciences Ukraine; University of Kiel; University of Kiel; Ministry of Education & Science of Ukraine; Borys Grinchenko Kyiv Metropolitan University; National Academy of Sciences Ukraine; Institute of Archaeology, National Academy of Sciences of Ukraine
  摘要：which published December 18, 2023; 10.1073/pnas.2312962120 (Proc. Natl. Acad. Sci. Stanislav ?erna should be added to the author list between Katharina Fuchs and forming research in an early stage of the study, and Pascal Flohr and Cheryl A. Makarewicz should be credited with contributing data analysis and interpretation in The authors also note that the author names Marta dal Corso and Andreea Terna should The corrected author line, affiliation line, and author contributions appear below. The...
• WAV E3 ubiquitin ligases mediate degradation of IAA32/34 in the TMK1-mediated auxin signaling pathway during apical hook development AI翻译
  作者：Wang, Jun-Li; Wang, Ming; Zhang, Li; Li, You-Xia; Li, Jing-Jing; Li, Yu-Yang; Pu, Zuo-Xian; Li, Dan-Yang; Liu, Xing-Nan; Guo, Wang; Di, Dong-Wei; Li, Xiao-Feng; Guo, Guang-Qin; Wu, Lei
  作者单位：Lanzhou University; Lanzhou University; Nanjing Agricultural University; Fujian Agriculture & Forestry University; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS
  摘要：Auxin regulates plant growth and development through downstream signaling pathways, including the best - known SCF TIR1/AFB - Aux/IAA - ARF pathway and several other less characterized noncanonical pathways. Recently, one SCF TIR1/AFB - independent noncanonical pathway, mediated by Transmembrane Kinase 1 (TMK1), was discovered through the analyses of its functions in Arabidopsis apical hook development. Asymmetric accumulation of auxin on the concave side of the apical hook triggers DAR1 - cat...
• Bmal1 integrates circadian function and temperature sensing in the suprachiasmatic nucleus AI翻译
  作者：Hoekstra, Marieke M. B.; Ness, Natalie; Soteras, Aina Badia-; Brancaccio, Marco
  作者单位：Imperial College London; Imperial College London
  摘要：Circadian regulation and temperature dependency are important orchestrators of molecular pathways. How the integration between these two drivers is achieved, is not understood. We monitored circadian - and temperature - dependent effects on transcription dynamics of cold - response protein RNA Binding Motif 3 (Rbm3). Temperature changes in the mammalian master circadian pacemaker, the suprachiasmatic nucleus (SCN), induced Rbm3 transcription and regulated its circadian periodicity, whereas the...