Bmal1 integrates circadian function and temperature sensing in the suprachiasmatic nucleus

• 成果类型: Article
• 署名作者: Hoekstra, Marieke M. B.; Ness, Natalie; Soteras, Aina Badia-; Brancaccio, Marco
• 署名单位: Imperial College London; Imperial College London
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15172
• DOI: 10.1073/pnas.2316646121
• 发表日期: 2024-04-23
• 关键词: clock; time

摘要

Circadian regulation and temperature dependency are important orchestrators of molecular pathways. How the integration between these two drivers is achieved, is not understood. We monitored circadian - and temperature - dependent effects on transcription dynamics of cold - response protein RNA Binding Motif 3 (Rbm3). Temperature changes in the mammalian master circadian pacemaker, the suprachiasmatic nucleus (SCN), induced Rbm3 transcription and regulated its circadian periodicity, whereas the core clock gene Per2 was unaffected. Rbm3 induction depended on a full Brain And Muscle ARNT - Like Protein 1 (Bmal1) complement: reduced Bmal1 erased Rbm3 responses and weakened SCN circuit resilience to temperature changes. By focusing on circadian and temperature dependency, we highlight weakened transmission between core clock and downstream pathways as a potential route for reduced circadian resilience.