-
作者：Rafiq, Nisha Mohd; Fujise, Kenshiro; Rosenfeld, Martin Shaun; Xu, Peng; De Camilli, Pietro
作者单位：Yale University; Yale University; Yale University; Eberhard Karls University of Tubingen
摘要：Synaptojanin - 1 (SJ1) is a major neuronal - enriched PI(4, 5)P 2 4 - and 5 - phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4 - phosphatase activity causes Parkinsonism in humans and neurological defects in mice (SJ1 RQ KI mice). Studies of these mice showed, besides an abnormal assembly state of endocytic factors at synapses, the presence of dystrophic nerve terminals selectively in a subset of nigro - striatal ...
-
作者：Chamberland, Simon; Grant, Gariel; Machold, Robert; Nebet, Erica R.; Tian, Guoling; Stich, Joshua; Hanani, Monica; Kullander, Klas; Tsien, Richard W.
作者单位：New York University; New York University; Uppsala University; New York University
摘要：Hippocampal somatostatinexpressing ( Sst ) GABAergic interneurons (INs) exhibit considerable anatomical and functional heterogeneity. Recent single - cell transcriptome analyses have provided a comprehensive Sst - IN subpopulations census, a plausible molecular ground truth of neuronal identity whose links to specific functionality remain incomplete. Here, we designed an approach to identify and access subpopulations of Sst - INs based on transcriptomic features. Four mouse models based on sin...
-
作者：Dharmasri, Poorna A.; Levy, Aaron D.; Blanpied, Thomas A.
作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
摘要：A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters (NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences the strength of synaptic transmission. However, whether nanocolumn properties vary between excitatory synapses functioning in different cellular contexts is unknown. We used a combination of confocal and DNA - PAINT super - resolution microscopy to directly compare the organization of shared scaffold proteins at two im...
-
作者：Iracane, Elise; Arias-Sarda, Cristina; Maufrais, Corinne; V. Ene, Iuliana; d'Enfert, Christophe; Buscaino, Alessia
作者单位：University of Kent; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; INRAE
摘要：RNA interference (RNAi) is a fundamental regulatory pathway with a wide range of functions, including regulation of gene expression and maintenance of genome stability. Although RNAi is widespread in the fungal kingdom, well - known species, such as the model yeast Saccharomyces cerevisiae , have lost the RNAi pathway. Until now evidence has been lacking for a fully functional RNAi pathway in Candida albicans , a human fungal pathogen considered critically important by the World Health Organiz...
-
作者：Johannesen, Niels; Martinello, Alessandro Tang- Andersen; Vestergaard, Emil Toft; Andersen, Asger Lau; Jensen, Thais Laerkholm
作者单位：University of Oxford; University of Copenhagen; University of Copenhagen
摘要：This paper presents quasiexperimental evidence of Covid - 19 transmission through casual contact between customers in retail stores. For a large sample of individuals in Denmark, we match card payment data, indicating exactly where and when each individual made purchases, with Covid - 19 test data, indicating when each individual was tested and whether the test was positive. The resulting dataset identifies more than 100,000 instances where an infected individual made a purchase in a store and...
-
作者：Shu, Sheng; Tsutsui, Yuko; Nathawat, Rajkanwar; Mi, Wei
作者单位：Yale University; Yale University; Yale University
摘要：Levels of lipopolysaccharide (LPS), an essential glycolipid on the surface of most gramnegative bacteria, are tightly controlled-making LPS synthesis a promising target for developing new antibiotics. Escherichia coli adaptor protein LapB (YciM) plays an important role in regulating LPS synthesis by promoting degradation of LpxC, a deacetylase that catalyzes the first committed step in LPS synthesis. Under conditions where LPS is abundant, LapB recruits LpxC to the AAA+ protease FtsH for degra...
-
作者：Wenzel, Arne; Westphal, Catrin; Ballauff, Johannes; Berkelmann, Dirk; Brambach, Fabian; Buchori, Damayanti; Camarretta, Nicolo; Corre, Marife D.; Daniel, Rolf; Darras, Kevin; Erasmi, Stefan; Formaglio, Greta; Hoelscher, Dirk; Iddris, Najeeb Al-Amin; Irawan, Bambang; Knohl, Alexander; Kotowska, Martyna M.; Krashevska, Valentyna; Kreft, Holger; Mulyani, Yeni; Musshoff, Oliver; Paterno, Gustavo B.; Polle, Andrea; Potapov, Anton; Roell, Alexander; Scheu, Stefan; Schlund, Michael; Schneider, Dominik; Sibhatu, Kibrom T.; Stiegler, Christian; Sundawati, Leti; Tjoa, Aiyen; Tscharntke, Teja; Veldkamp, Edzo; Waite, Pierre- Andre; Wollni, Meike; Zemp, Delphine Clara; Grass, Ingo
作者单位：University of Gottingen; University of Gottingen; University of Gottingen; University of Twente; University Hohenheim; Universidad Costa Rica; University of Gottingen; Bogor Agricultural University; University of Gottingen; University of Gottingen; Johann Heinrich von Thunen Institute; University of Gottingen; Universitas Jambi; University of Gottingen; University of Gottingen; Bogor Agricultural University; University of Gottingen; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; University of Gottingen; Bogor Agricultural University; Universitas Tadulako; University of Gottingen; Technische Universitat Dresden; University of Neuchatel; University Hohenheim
摘要：The expansion of the oil palm industry in Indonesia has improved livelihoods in rural communities, but comes at the cost of biodiversity and ecosystem degradation. Here, we investigated ways to balance ecological and economic outcomes of oil palm cultivation. We compared a wide range of production systems, including smallholder plantations, industrialized company estates, estates with improved agronomic management, and estates with native tree enrichment. Across all management types, we assess...
-
作者：Freedman, Ari S.; Sheen, Justin K.; Tsai, Stella; Yao, Jihong; Lifshitz, Edward; Adinaro, David; Levin, Simon A.; Grenfell, Bryan T.; Metcalf, C. Jessica E.
作者单位：Princeton University; New Jersey Department of Health & Senior Services
摘要：Characterizing the relationship between disease testing behaviors and infectious disease dynamics is of great importance for public health. Tests for both current and past infection can influence disease -related behaviors at the individual level, while population -level knowledge of an epidemic's course may feed back to affect one's likelihood of taking a test. The COVID-19 pandemic has generated testing data on an unprecedented scale for tests detecting both current infection (PCR, antigen) ...
-
作者：Lorenzo, J. Paulo; Molla, Linda; Amro, Elias Moris; Ibarra, Ignacio L.; Ruf, Sandra; Neber, Cedrik; Gkougkousis, Christos; Ridani, Jana; Subramani, Poorani Ganesh; Boulais, Jonathan; Harjanto, Dewi; Vonica, Alin; Di Noia, Javier M.; Dieterich, Christoph; Zaugg, Judith B.; Papavasiliou, F. Nina
作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Rockefeller University; European Molecular Biology Laboratory (EMBL); Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; McGill University; Universite de Montreal; Ruprecht Karls University Heidelberg; German Centre for Cardiovascular Research
摘要：The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide (APOBEC) family is composed of nucleic acid editors with roles ranging from antibody diversification to RNA editing. APOBEC2, a member of this family with an evolutionarily conserved nucleic acid-binding cytidine deaminase domain, has neither an established substrate nor function. Using a cellular model of muscle differentiation where APOBEC2 is inducibly expressed, we confirmed that APOBEC2 does not have the attributed m...
-
作者：Takeshita, Rafaela S. C.
作者单位：University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent
