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作者：Okabe, Yuta; Murakoshi, Nobuyuki; Kurebayashi, Nagomi; Inoue, Hana; Ito, Yoko; Murayama, Takashi; Miyoshi, Chika; Funato, Hiromasa; Ishii, Koichiro; Xu, Dongzhu; Tajiri, Kazuko; Qin, Rujie; Aonuma, Kazuhiro; Murakata, Yoshiko; Song, Zonghu; Wakana, Shigeharu; Yokoyama, Utako; Sakurai, Takashi; Aonuma, Kazutaka; Ieda, Masaki; Yanagisawa, Masashi
作者单位：University of Tsukuba; Juntendo University; Tokyo Medical University; University of Tsukuba; RIKEN; Keio University
摘要：Inherited arrhythmia syndromes (IASs) can cause life - threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development of devices to prevent SCDs, the precise molecular mechanisms that induce detrimental arrhythmias remain to be fully investigated, and more effective therapies are desirable. In the present study, we screened a large - scale randomly mutagenized mouse library by electrocardiography to establish a dise...
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作者：De, Kavita; Belardinelli, Juan M.; Pandurangan, Arun Prasad; Ehianeta, Teddy; Lian, Elena; Palcekova, Zuzana; Lam, Ha; Gonzalez-juarrero, Mercedes; Bryant, Josephine M.; Blundell, Tom L.; Parkhill, Julian; Floto, R. Andres; Lowary, Todd L.; Wheat, William H.; Jackson, Mary
作者单位：Colorado State University System; Colorado State University Fort Collins; Academia Sinica - Taiwan; University of Cambridge; University of Cambridge; MRC Laboratory Molecular Biology; University of Cambridge; Papworth Hospital; National Taiwan University
摘要：Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient - derived embC mutations on the physiology and virulence of M. abscessus , mutations were introduc...
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作者：Fukami, Yusuke; Ariizumi, Ryoko; Ijichi, Yuta; Ohno, Takeshi; Kashiwabara, Teruhiko; Shibuya, Takazo; Suzuki, Katsuhiko; Hirata, Takafumi
作者单位：Gakushuin University; University of Tokyo; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Japan Agency for Marine-Earth Science & Technology (JAMSTEC)
摘要：Experimental results are presented showing the variation in the relationship between odd isotopes of tin (Sn) in mass - independent fractionation caused by the magnetic isotope effect (MIE), which has previously only been observed for mercury. These results are consistent with the trend predicted from the difference between the magnitudes of nuclear magnetic moments of odd isotopes with a nuclear spin. However, the correlation between odd isotopes in fractionation induced by the MIE for the re...
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作者：Marzuki, Sangkot; Buchori, Damayanti; Alberts, Bruce
作者单位：Bogor Agricultural University; University of California System; University of California San Francisco
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作者：Galloni, Alessandro R.; Yuan, Yifan; Zhu, Minning; Yu, Haoming; Bisht, Ravindra S.; Wu, Chung-Tse Michael; Grienberger, Christine; Ramanathan, Shriram; Milstein, Aaron D.
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Purdue University System; Purdue University; Brandeis University; Brandeis University; Brandeis University
摘要：Design of hardware based on biological principles of neuronal computation and plasticity in the brain is a leading approach to realizing energy- and sample- efficient AI and learning machines. An important factor in selection of the hardware building blocks is the identification of candidate materials with physical properties suitable to emulate the large dynamic ranges and varied timescales of neuronal signaling. Previous work has shown that the all- or- none spiking behavior of neurons can b...
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作者：Gu, Lijie; Du, Yanhong; Chen, Jianglei; Hasan, Mohammad Nazmul; Clayton, Yung Dai; Matye, David J.; Friedman, Jacob E.; Li, Tiangang
作者单位：University of Oklahoma System; University of Oklahoma Health Sciences Center
摘要：Cullin RING E3 ligases (CRL) have emerged as key regulators of disease - modifying pathways and therapeutic targets. Cullin3 (Cul3) - containing CRL (CRL3) has been implicated in regulating hepatic insulin and oxidative stress signaling. However, CRL3 function in liver pathophysiology is poorly defined. Here, we report that hepatocyte Cul3 knockout results in rapid resolution of steatosis in obese mice. However, the remarkable resistance of hepatocyte Cul3 knockout mice to developing steatosis...
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作者：Liu, Xing; Zhu, Chunchun; Jia, Shuke; Deng, Hongyan; Tang, Jinhua; Sun, Xueyi; Zeng, Xiaoli; Chen, Xiaoyun; Wang, Zixuan; Liao, Qian; Liu, Wen; Zha, Huangyuan; Cai, Xiaolian; Xiao, Wuhan
作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：To effectively protect the host from viral infection while avoiding excessive immunopathology, the innate immune response must be tightly controlled. However, the precise regulation of antiviral innate immunity and the underlying mechanisms remain unclear. Here, we find that sirtuin3 (SIRT3) interacts with mitochondrial antiviral signaling protein (MAVS) to catalyze MAVS deacetylation at lysine residue 7 (K7), which promotes MAVS aggregation, as well as TANK - binding kinase I and IRF3 phospho...
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作者：Papini, Christina; Ullah, Irfan; Ranjan, Amalendu P.; Zhang, Shuo; Wu, Qihao; Spasov, Krasimir A.; Zhang, Chunhui; Mothes, Walther; Crawford, Jason M.; Lindenbach, Brett D.; Uchil, Pradeep D.; Kumar, Priti; Jorgensen, William L.; Anderson, Karen S.
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University
摘要：As the SARSCoV - 2 virus continues to spread and mutate, it remains important to focus not only on preventing spread through vaccination but also on treating infection with direct - acting antivirals (DAA). The approval of Paxlovid, a SARSCoV - 2 main protease (M pro ) DAA, has been significant for treatment of patients. A limitation of this DAA, however, is that the antiviral component, nirmatrelvir, is rapidly metabolized and requires inclusion of a CYP450 3A4 metabolic inhibitor, ritonavir,...
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作者：Watanabe, Yoshihiro; Haneda, Takeshi; Kimishima, Aoi; Kuwae, Asaomi; Suga, Takuya; Suzuki, Takahiro; Iwabuchi, Yoshiharu; Honsho, Masako; Honma, Sota; Iwatsuki, Masato; Matsui, Hidehito; Hanaki, Hideaki; Kanoh, Naoki; Abe, Akio; Asami, Yukihiro; Omura, Satoshi
作者单位：Kitasato University; Kitasato University; Kitasato University; Tohoku University; Hoshi University; Hoshi University
摘要：Anti - microbial resistance (AMR) is one of the greatest threats to global health. The continual battle between the emergence of AMR and the development of drugs will be extremely difficult to stop as long as traditional anti - biotic approaches are taken. In order to overcome this impasse, we here focused on the type III secretion system (T3SS), which is highly conserved in many Gram - negative pathogenic bacteria. The T3SS is known to be indispensable in establishing disease processes but no...
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作者：Bougouin, Alexis; Metzger, Bloen; Forterre, Yoel; Boustingorry, Pascal; Lhuissier, Henri
作者单位：Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite
摘要：Pipe flows are commonly found in nature and industry as an effective mean of transporting fluids. They are primarily characterized by their resistance law, which relates the mean flow rate to the driving pressure gradient. Since Poiseuille and Hagen, various flow regimes and fluid rheologies have been investigated, but the behavior of shear -thickening suspensions, which jam above a critical shear stress, remains poorly understood despite important applications (e.g., concrete or food processi...
