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作者：An, Zhichao; Yang, Yi; Yang, Xue; Ma, Wenqi; Jiang, Wei; Li, Yajuan; Chen, Guangfeng; Zhang, Weifeng; Zhuang, Minghao; Wang, Chong; Zhang, Fusuo
作者单位：China Agricultural University; China Agricultural University; Chongqing University; Henan Agricultural University; Hebei Agricultural University
摘要：Transforming smallholder farms is critical to global food security and environmental sustainability. The science and technology backyard (STB) platform has proved to be a viable approach in China. However, STB has traditionally focused on empowering smallholder farmers by transferring knowledge, and wide-scale adoption of more sustainable practices and technologies remains a challenge. Here, we report on a long-term project focused on technology scale-up for smallholder farmers by expanding an...
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作者：Eren, Elif; Watts, Norman R.; Conway, James F.; Wingfield, Paul T.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Encapsulins are protein nanocompartments that regulate cellular metabolism in several bacteria and archaea. Myxococcus xanthus encapsulins protect the bacterial cells against oxidative stress by sequestering cytosolic iron. These encapsulins are formed by the shell protein EncA and three cargo proteins: EncB, EncC, and EncD. EncB and EncC form rotationally symmetric decamers with ferroxidase centers (FOCs) that oxidize Fe +2 to Fe +3 for iron storage in mineral form. However, the structure and...
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作者：Geng, Sha; Liu, Song- Bai; He, Wei; Pan, Xiangbin; Sun, Yi; Xue, Ting; Han, Shiyuan; Lou, Jing; Chang, Ying; Zheng, Jiqing; Shi, Xinghong; Li, Yangxin; Song, Yao- Hua
作者单位：Soochow University - China; Soochow University - China; Soochow University - China; Suzhou Vocational Health College; Chinese Academy of Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS; Peking Union Medical College
摘要：Myogenic regeneration relies on the proliferation and differentiation of satellite cells. TECRL (trans - 2,3 - enoyl - CoA reductase like) is an endoplasmic reticulum protein only expressed in cardiac and skeletal muscle. However, its role in myogenesis remains unknown. We show that TECRL expression is increased in response to injury. Satellite cell - specific deletion of TECRL enhances muscle repair by increasing the expression of EGR2 through the activation of the ERK1/2 signaling pathway, w...
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作者：van Zwieten, Ralph; Bierman, Thijs V.; Klinkhamer, Peter G. L.; Bezemer, T. Martijn; Vrieling, Klaas; Kodger, Thomas E.
作者单位：Wageningen University & Research; Leiden University - Excl LUMC; Leiden University
摘要：With a continuous increase in world population and food production, chemical pesticide use is growing accordingly, yet unsustainably. As chemical pesticides are harmful to the environment and developmental resistance in pests is increasing, a sustainable and effective pesticide alternative is needed. Inspired by nature, we mimic one defense strategy of plants, glandular trichomes, to shift away from using chemical pesticides by moving toward a physical immobilization strategy via adhesive part...
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作者：Zhu, Xiaohong; Luo, Mengqi; An, Ke; Shi, Danfeng; Hou, Tingjun; Warshel, Arieh; Bai, Chen
作者单位：The Chinese University of Hong Kong, Shenzhen; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shenzhen University; Zhejiang University; University of Southern California
摘要：Homomeric dimerization of metabotropic glutamate receptors (mGlus) is essential for the modulation of their functions and represents a promising avenue for the development of novel therapeutic approaches to address central nervous system diseases. Yet, the scarcity of detailed molecular and energetic data on mGlu2 impedes our in - depth comprehension of their activation process. Here, we employ computational simulation methods to elucidate the activation process and key events associated with ...
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作者：Chen, Jizhang; Chen, Minfeng; Chen, Hongli; Yang, Ming; Han, Xiang; Ma, Dingtao; Zhang, Peixin; Wong, Ching - Ping
作者单位：Nanjing Forestry University; East China University of Science & Technology; Shenzhen University; University System of Georgia; Georgia Institute of Technology
摘要：While aqueous zinc- ion batteries exhibit great potential, their performance is impeded by zinc dendrites. Existing literature has proposed the use of hydrogel electrolytes to ameliorate this issue. Nevertheless, the mechanical attributes of hydrogel electrolytes, particularly their modulus, are suboptimal, primarily ascribed to the substantial water content. This drawback would severely restrict the dendrite- inhibiting efficacy, especially under large mass loadings of active materials. Inspi...
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作者：Ferrarone, John R.; Thomas, Jerin; Unni, Arun M.; Zheng, Yuxiang; Nagiec, Michal J.; Gardner, Eric E.; Mashadova, Oksana; Li, Kate; Koundouros, Nikos; Montalbano, Antonino; Mustafa, Meer; Cantley, Lewis C.; Blenis, John; Sanjana, Neville E.; Varmus, Harold
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; New York University; Cornell University; Weill Cornell Medicine; Northwell Health; Hofstra University; Harvard University; Harvard Medical School; Regeneron; 23andMe, Inc.
摘要：The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell polarity and metabolism; however, the pathways that mediate the tumor - suppressive activity of LKB1 are incompletely defined. To identify mechanisms of LKB1mediated growth suppression, we developed a spheroid - based cell culture assay to study LKB1dependent growth. We then performed genome - wid...
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作者：Kauai, Felipe; Bafort, Quinten; Mortier, Frederik; Van Montagu, Marc; Bonte, Dries; Van de Peer, Yves
作者单位：Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; University of Pretoria; Nanjing Agricultural University
摘要：Hybridization blurs species boundaries and leads to intertwined lineages resulting in reticulate evolution. Polyploidy, the outcome of whole genome duplication (WGD), has more recently been implicated in promoting and facilitating hybridization between polyploid species, potentially leading to adaptive introgression. However, because polyploid lineages are usually ephemeral states in the evolutionary history of life it is unclear whether WGD - potentiated hybridization has any appreciable effe...
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作者：Segovia, Danilo; Adams, Dexter W.; Hoffman, Nickolas; Tepes, Polona Safaric; Wee, Tse-Luen; Cifani, Paolo; Joshua-Tor, Leemor; Krainer, Adrian R.
作者单位：Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University; Howard Hughes Medical Institute; Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University
摘要：SRSF1 is the founding member of the SR protein family. It is required- interchangeably with other SR proteins-for pre-mRNA splicing in vitro, and it regulates various alternative splicing events. Dysregulation of SRSF1 expression contributes to cancer and other pathologies. Here, we characterized SRSF1's interactome using proximity labeling and mass spectrometry. This approach yielded 190 proteins enriched in the SRSF1 samples, independently of the N- or C - terminal location of the biotin- la...
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作者：Clark, Cory J.; al-Gharbi, Musa; Baumeister, Roy F.; Bleske-Rechek, April; Buss, David; Ceci, Stephen; Forgas, Joseph; Frey, Komi; Geary, David C.; Geher, Glenn; Del Giudice, Marco; Jussim, Lee S.; Krylov, Anna I.; Martin, Chris; Miller, Geoffrey; Paresky, Pamela; Salmon, Catherine; Stewart-Williams, Steve; Wilson, Anne E.; Williams, Wendy; Winegard, Bo M.; von Hippel, William
作者单位：University of Pennsylvania; University of Pennsylvania; State University of New York (SUNY) System; Stony Brook University; University of Queensland; University of Wisconsin System; University of Wisconsin Eau Claire; University of Texas System; University of Texas Austin; Cornell University; University of New South Wales Sydney; University of Missouri System; University of Missouri Columbia; State University of New York (SUNY) System; SUNY New Paltz; University of Trieste; Rutgers University System; Rutgers University New Brunswick; University of Southern California; University of New Mexico; University Redlands; University of Nottingham Malaysia; Wilfrid Laurier University
