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作者：Gully, Kay; Berhin, Alice; De Bellis, Damien; Herrfurth, Cornelia; Feussner, Ivo; Nawrath, Christiane
作者单位：University of Lausanne; University of Lausanne; University of Gottingen; University of Gottingen; University of Gottingen
摘要：Lipid polymers such as cutin and suberin strengthen the diffusion barrier properties of the cell wall in specific cell types and are essential for water relations, mineral nutrition, and stress protection in plants. Land plant-specific glycerol - 3 - phosphate acyltransferases (GPATs) of different clades are central players in cutin and suberin monomer biosynthesis. Here, we show that the GPAT4 / 6 / 8 clade in Arabidopsis thaliana , which is known to mediate cutin formation, is also required ...
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作者：Hsu, Chun Chih; Takahashi, Hiroto; Jerzembeck, Fabian; Dasini, Jahnatta; Carroll, Chaia; Dusad, Ritika; Ward, Jonathan; Dawson, Catherine; Sharma, Sudarshan; Luke, Graeme M.; Blundell, Stephen J.; Castelnovo, Claudio; Hallen, Jonathan N.; Moessner, Roderich; Davis, J. C. Seamus
作者单位：University of Oxford; Max Planck Society; University College Cork; McMaster University; University of Cambridge; Max Planck Society; Cornell University
摘要：A recent advance in the study of emergent magnetic monopoles was the discovery that monopole motion is restricted to dynamical fractal trajectories [J. N. Hall & eacute;n et al. , Science 378 , 1218 (2022)], thus explaining the characteristics of magnetic monopole noise spectra [R. Dusad et al., Nature 571 , 234 (2019); A. M. Samarakoon et al. , Proc. Natl. Acad. Sci. U.S.A. 119 , e2117453119 (2022)]. Here, we apply this novel theory to explore the dynamics of field - driven monopole currents,...
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作者：Nagahata, Yutaka; Kobayashi, Masato; Toda, Mikito; Maeda, Satoshi; Taketsugu, Tetsuya; Komatsuzaki, Tamiki
作者单位：Hokkaido University; Hokkaido University; Hokkaido University; Nara Womens University; University of Hyogo; University of Osaka; University of Osaka
摘要：Complex networks are pervasive in various fields such as chemistry, biology, and sociology. In chemistry, first-order reaction networks are represented by a set of first-order differential equations, which can be constructed from the underlying energy landscape. However, as the number of nodes increases, it becomes more challenging to understand complex kinetics across different timescales. Hence, how to construct an interpretable, coarse-graining scheme that preserves the underlying timescale...
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作者：Zhang, Wei; Poon, Tsz Fung; Tsang, Chun Wai; Wang, Wenyan; Liu, X.; Xie, J.; Lam, S. T.; Wang, Shanmin; Lai, Kwing To; Pourret, A.; Seyfarth, G.; Knebel, G.; Yu, Wing Chi; Goh, Swee K.
作者单位：Chinese University of Hong Kong; Southern University of Science & Technology; Chinese University of Hong Kong; CUHK Shenzhen Research Institute; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National Polytechnique de Grenoble; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National des Sciences Appliquees de Toulouse; Centre National de la Recherche Scientifique (CNRS); City University of Hong Kong
摘要：The kagome metal CsV3Sb5 is an ideal platform to study the interplay between topology and electron correlation. To understand the fermiology of CsV3Sb5, intensive quantum oscillation (QO) studies at ambient pressure have been conducted. However, due to the Fermi surface reconstruction by the complicated charge density wave (CDW) order, the QO spectrum is exceedingly complex, hindering a complete understanding of the fermiology. Here, we directly map the Fermi surface of the pristine CsV3Sb5 by...
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作者：Zhao, Haiqing; Petrey, Donald; Murray, Diana; Honig, Barry
作者单位：NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Columbia University; Columbia University
摘要：We introduce ZEPPI (Z - score Evaluation of Protein-Protein Interfaces), a framework to evaluate structural models of a complex based on sequence coevolution and conservation involving residues in protein-protein interfaces. The ZEPPI score is calculated by comparing metrics for an interface to those obtained from randomly chosen residues. Since contacting residues are defined by the structural model, this obviates the need to account for indirect interactions. Further, although ZEPPI relies o...
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作者：Castanha, Priscila M. S.; McEnaney, Patrick J.; Park, Yongseok; Bouwer, Anthea; Chaves, Elton J. F.; Lins, Roberto D.; Paciaroni, Nicholas G.; Dickson, Paige; Carlson, Graham; Cordeiro, Marli T.; Magalhaes, Tereza; Craigo, Jodi; Marques, Ernesto T. A.; Kodadek, Thomas; Burke, Donald S.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Universidade Federal de Pernambuco; Fundacao Oswaldo Cruz; Texas A&M University System; Texas A&M University College Station; Universidade Federal da Bahia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Antigenic similarities between Zika virus (ZIKV) and other flaviviruses pose challenges to the development of virus-specific diagnostic tools and effective vaccines. Starting with a DNA-encoded one-bead-one-compound combinatorial library of 508,032 synthetic, non-natural oligomers, we selected and characterized small molecules that mimic ZIKV epitopes. High-throughput fluorescence-activated cell sorter-based bead screening was used to select molecules that bound IgG from ZIKV-immune but not fr...
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作者：Chai, Mengzhu; Li, Lei; Li, Yong; Yang, Yingshuai; Wang, Yuting; Jiang, Xue; Luan, Yameng; Li, Fangfang; Cui, Hongguang; Wang, Aiming; Xiang, Wensheng; Wu, Xiaoyun; Cheng, Xiaofei
作者单位：Northeast Agricultural University - China; Northeast Agricultural University - China; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; Hainan University; Agriculture & Agri Food Canada
摘要：Potyviridae, the largest family of plant RNA viruses, includes many important pathogens that significantly reduce the yields of many crops worldwide. In this study, we report that the 6-kilodalton peptide 1 (6K1), one of the least characterized potyviral proteins, is an endoplasmic reticulum-localized protein. AI-assisted structure modeling and biochemical assays suggest that 6K1 forms pentamers with a central hydrophobic tunnel, can increase the cell membrane permeability of Escherichia coli ...
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作者：Geisberg, Joseph, V; Moqtaderi, Zarmik; Struhl, Kevin
作者单位：Harvard University; Harvard Medical School
摘要：The RNA polymerase II (Pol II) elongation rate influences poly(A) site selection, with slow and fast Pol II derivatives causing upstream and downstream shifts, respectively, in poly(A) site utilization. In yeast, depletion of either of the histone chaperones FACT or Spt6 causes an upstream shift of poly(A) site use that strongly resembles the poly(A) profiles of slow Pol II mutant strains. Like slow Pol II mutant strains, FACT - and Spt6 - depleted cells exhibit Pol II processivity defects, in...
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作者：Jaafari, Hana; Bueno, Carlos; Schafer, Nicholas P.; Martin, Jonathan; Morcos, Faruck; Wolynes, Peter G.
作者单位：Rice University; Rice University; Rice University; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; Rice University; Rice University
摘要：Protein evolution is guided by structural, functional, and dynamical constraints ensuring organismal viability. Pseudogenes are genomic sequences identified in many eukaryotes that lack translational activity due to sequence degradation and thus over time have undergone devolution. Previously pseudogenized genes sometimes regain their protein-coding function, suggesting they may still encode robust folding energy landscapes despite multiple mutations. We study both the physical folding landsca...
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作者：Lafuente-Bartolome, Jon; Lian, Chao; Giustino, Feliciano
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Halide perovskites emerged as a revolutionary family of high -quality semiconductors for solar energy harvesting and energy -efficient lighting. There is mounting evidence that the exceptional optoelectronic properties of these materials could stem from unconventional electron-phonon couplings, and it has been suggested that the formation of polarons and self -trapped excitons could be key to understanding such properties. By performing first -principles simulations across the length scales, h...
