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作者：Wang, David; Frechette, Layne B.; Best, Robert B.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); Johns Hopkins University; Brandeis University
摘要：The consistency of energy landscape theory predictions with available experimental data, as well as direct evidence from molecular simulations, have shown that protein folding mechanisms are largely determined by the contacts present in the native structure. As expected, native contacts are generally energetically favorable. However, there are usually at least as many energetically favorable nonnative pairs owing to the greater number of possible nonnative interactions. This apparent frustrati...
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作者：Gao, Shujuan; Rodriguez, Jake W. Carrasquillo; Bahmanyar, Shirin; Airola, Michael V.
作者单位：State University of New York (SUNY) System; Stony Brook University; Yale University
摘要：C - terminal Domain Nuclear Envelope Phosphatase 1 (CTDNEP1) is a noncanonical protein serine/threonine phosphatase that has a conserved role in regulating ER membrane biogenesis. Inactivating mutations in CTDNEP1 correlate with the development of medulloblastoma, an aggressive childhood cancer. The transmembrane protein Nuclear Envelope Phosphatase 1 Regulatory Subunit 1 (NEP1R1) binds CTDNEP1, but the molecular details by which NEP1R1 regulates CTDNEP1 function are unclear. Here, we find tha...
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作者：Jahnke, Kevin; Pavlovic, Marko; Xu, Wentao; Chen, Anqi; Knowles, Tuomas P. J.; Arriaga, Laura R.; Weitz, David A.
作者单位：Harvard University; University of Cambridge; Autonomous University of Madrid; Autonomous University of Madrid; Harvard University; Harvard University
摘要：The biophysical properties of lipid vesicles are important for their stability and integrity, key parameters that control the performance when these vesicles are used for drug delivery. The vesicle properties are determined by the composition of lipids used to form the vesicle. However, for a given lipid composition, they can also be tailored by tethering polymers to the membrane. Typically, synthetic polymers like polyethyleneglycol are used to increase vesicle stability, but the use of polys...
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作者：Scaletti, Carla; Russell, Premila P. Samuel; Hebel, Kurt J.; Rickard, Meredith M.; Boob, Mayank; Danksagmueller, Franz; Taylor, Stephen A.; V. Pogorelov, Taras; Gruebele, Martin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Protein-protein and protein-water hydrogen bonding interactions play essential roles in the way a protein passes through the transition state during folding or unfolding, but the large number of these interactions in molecular dynamics (MD) simulations makes them difficult to analyze. Here, we introduce a state space representation and associated rarity measure to identify and quantify transition state passage (transit) events. Applying this representation to a long MD simulation trajectory th...
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作者：Yang, Chen; Dong, Xinrui; Sun, Bingrui; Cao, Ting; Xie, Ruipei; Zhang, Yiyu; Yang, Ziyue; Huang, Jing; Lu, Ying; Li, Ming; Wang, Xiaochen; Xu, Ye; Ye, Fangfu; Fan, Qihui
作者单位：Beihang University; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Oujiang Laboratory
摘要：The significance of biochemical cues in the tumor immune microenvironment in affecting cancer metastasis is well established, but the role of physical factors in the microenvironment remains largely unexplored. In this article, we investigated how the mechanical interaction between cancer cells and immune cells, mediated by extracellular matrix (ECM), influences immune escape of cancer cells. We focus on the mechanical regulation of macrophages' targeting ability on two distinct types of color...
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作者：Cowling, Craig L.; Homayouni, Arielle L.; Callwood, Jodi B.; Mcreynolds, Maxwell R.; Khor, Jasper; Ke, Haiyan; Draves, Melissa A.; Dehesh, Katayoon; Walley, Justin W.; Strader, Lucia C.; Kelley, Dior R.
作者单位：Iowa State University; Duke University; Iowa State University; University of California System; University of California Riverside
摘要：Plant root systems play a pivotal role in plant physiology and exhibit diverse phenotypic traits. Understanding the genetic mechanisms governing root growth and development in model plants like maize is crucial for enhancing crop resilience to drought and nutrient limitations. This study focused on identifying and characterizing ZmPILS6, an annotated auxin efflux carrier, as a key regulator of various crown root traits in maize. ZmPILS6 - modified roots displayed reduced network area and suppr...
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作者：Kamani, Krutarth M.; Rogers, Simon A.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
摘要：Many soft materials yield under mechanical loading, but how this transition solid -like behavior to liquid -like behavior occurs can vary significantly. Understanding the physics of yielding is of great interest for the behavior of biological, environmental, and industrial materials, including those used as inks in additive manufacturing muds and soils. For some materials, the yielding transition is gradual, while others abruptly. We refer to these behaviors as being ductile and brittle. The k...
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作者：Van Passel, Johanna; Bernardino, Paulo N.; Lhermitte, Stef; Rius, Bianca F.; Hirota, Marina; Conradi, Timo; de Keersmaecker, Wanda; Van Meerbeek, Koenraad; Somers, Ben
作者单位：KU Leuven; KU Leuven; Universidade Estadual de Campinas; Delft University of Technology; Universidade Estadual de Campinas; Universidade Federal de Santa Catarina (UFSC); University of Bayreuth; VITO
摘要：Dynamic ecosystems, such as the Amazon forest, are expected to show critical slowing down behavior, or slower recovery from recurrent small perturbations, as they approach an ecological threshold to a different ecosystem state. Drought occurrences are becoming more prevalent across the Amazon, with known negative effects on forest health and functioning, but their actual role in the critical slowing down patterns still remains elusive. In this study, we evaluate the effect of trends in extreme...
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作者：Zhang, Xiao-Feng; Li, Zhanpeng; Lin, Hanbin; Cheng, Yu; Wang, Huanqin; Jiang, Zhoumian; Ji, Zhenxi; Huang, Zhejun; Chen, Hongyan; Wei, Taiyun
摘要：Leaf yellowing is a well- known phenotype that attracts phloem- feeding insects. However, facilitate their own transmission by insect vectors. Here, we report that an effector protein secreted by rice orange leaf phytoplasma (ROLP) inhibits chlorophyll biosynthesis and induces leaf yellowing to attract leafhopper vectors, thereby presumably promoting pathogen transmission. This effector, designated secreted ROLP protein 1 (SRP1), first secreted into rice phloem by ROLP, was subsequently transl...
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作者：Brennan, Eric B.
作者单位：United States Department of Agriculture (USDA)
