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作者：Lichand, Guilherme; Doria, Carlos Alberto
作者单位：Universidade de Brasilia
摘要：The transition to remote learning in the context of COVID-19 led to dramatic setbacks in education. Is the return to in -person classes sufficient to eliminate these losses eventually? We study this question using data from the universe of secondary students in S & atilde;o Paulo State, Brazil. We estimate the causal medium -run impacts of the length of exposure to remote learning during the pandemic through a triple -differences strategy, which contrasts changes in educational outcomes across...
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作者：Mei, Menghan; Cupic, Anastasija; Miorin, Lisa; Ye, Chengjin; Cagatay, Tolga; Zhang, Ke; Patel, Komal; Wilson, Natalie; McDonald, W. Hayes; Crossland, Nicholas A.; Lo, Ming; Rutkowska, Magdalena; Aslam, Sadaf; Mena, Ignacio; Martinez-Sobrido, Luis; Ren, Yi; Garcia-Sastre, Adolfo; Fontoura, Beatriz M. A.
作者单位：Vanderbilt University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Texas Biomedical Research Institute; University of Texas System; University of Texas Southwestern Medical Center; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Vanderbilt University; Vanderbilt University; Boston University; Boston University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Scripps Research Institute
摘要：The nonstructural protein 1 (Nsp1) of SARS - CoV - 2 (Severe Acute Respiratory Syndrome Coronavirus 2) is a virulence factor that targets multiple cellular pathways to inhibit host gene expression and antiviral response. However, the underlying mechanisms of the various Nsp1mediated functions and their contributions to SARS - CoV - 2 virulence remain unclear. Among the targets of Nsp1 is the mRNA (messenger ribonucleic acid) export receptor NXF1 - NXT1, which mediates nuclear export of mRNAs f...
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作者：Yao, Run - Wen; Rosen, Michael K.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Biomolecular condensates are cellular compartments that concentrate biomolecules without an encapsulating membrane. In recent years, significant advances have been made in the understanding of condensates through biochemical reconstitution and microscopic detection of these structures. Quantitative visualization and biochemical assays of biomolecular condensates rely on surface passivation to minimize background and artifacts due to condensate adhesion. However, the challenge of undesired inte...
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作者：Blau, Wolfgang; Cerf, Vinton G.; Enriquez, Juan; Francisco, Joseph S.; Gasser, Urs; Gray, Mary L.; Greaves, Mark; Grosz, Barbara J.; Jamieson, Kathleen Hall; Haug, Gerald H.; Hennessy, John L.; Horvitz, Eric; Kaiser, David I.; London, Alex John; Lovell-Badge, Robin; McNutt, Marcia K.; Minow, Martha; Mitchell, Tom M.; Ness, Susan; Parthasarathy, Shobita; Perlmutter, Saul; Press, William H.; Wing, Jeannette M.; Witherell, Michael
作者单位：Alphabet Inc.; Google Incorporated; University of Pennsylvania; University of Pennsylvania; Technical University of Munich; Indiana University System; Indiana University Bloomington; Harvard University; University of Pennsylvania; Stanford University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Carnegie Mellon University; Francis Crick Institute; National Academies of Sciences, Engineering & Medicine; Harvard University; Carnegie Mellon University; University of Michigan System; University of Michigan; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Texas System; University of Texas Austin; Columbia University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
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作者：Ciamarra, Massimo Pica; Ji, Wencheng; Wyart, Matthieu
作者单位：Nanyang Technological University; Consiglio Nazionale delle Ricerche (CNR); Weizmann Institute of Science; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Which phenomenon slows down the dynamics in supercooled liquids and turns them into glasses is a long-standing question of condensed matter. Most popular theories posit that as the temperature decreases, many events must occur in a coordinated fashion on a growing length scale for relaxation to occur. Instead, other approaches consider that local barriers associated with the elementary rearrangement of a few particles or excitations govern the dynamics. To resolve this conundrum, our central r...
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作者：Goto, Sawako; Tsutsumi, Akihisa; Lee, Yongchan; Hosojima, Michihiro; Kabasawa, Hideyuki; Komochi, Koichi; Nagatoishi, Satoru; Takemoto, Kazuya; Tsumoto, Kouhei; Nishizawa, Tomohiro; Kikkawa, Masahide; Saito, Akihiko
作者单位：Niigata University; University of Tokyo; Yokohama City University; Niigata University; University of Tokyo; University of Tokyo; Daiichi Sankyo Company Limited
摘要：Megalin (low - density lipoprotein receptor - related protein 2) is a giant glycoprotein of about 600 kDa, mediating the endocytosis of more than 60 ligands, including those of proteins, peptides, and drug compounds [S. Goto, M. Hosojima, H. Kabasawa, A. Saito, Int. J. Biochem. Cell Biol. 157 , 106393 (2023)]. It is expressed predominantly in renal proximal tubule epithelial cells, as well as in the brain, lungs, eyes, inner ear, thyroid gland, and placenta. Megalin is also known to mediate th...
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作者：Shioda, Tatsuya; Nakamura, Shuhei
作者单位：University of Osaka; Nara Medical University
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作者：Tang, Kai; Zhu, Xiaohong; Xie, Shaojun; Lang, Zhaobo; Zhu, Jian-Kang
作者单位：Purdue University System; Purdue University; Henan University; Henan University; Purdue University System; Purdue University; Southern University of Science & Technology; Southern University of Science & Technology
摘要：Spontaneous gain or loss of DNA methylation occurs in plant and animal genomes, and DNA methylation changes can lead to meiotically stable epialleles that generate heritable phenotypic diversity. However, it is unclear whether transgenerational epigenetic stability may be regulated by any cellular factors. Here, we examined spontaneously occurring variations in DNA methylation in wild - type and ros1 mutant Arabidopsis plants that were propagated for ten generations from single - seed descent....
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作者：Wang, Siyu; Zhang, Yuebao; Zhong, Yichen; Xue, Yonger; Liu, Zhengwei; Wang, Chang; Kang, Diana D.; Li, Haoyuan; Hou, Xucheng; Tian, Meng; Cao, Dinglingge; Wang, Leiming; Guo, Kaiyuan; Deng, Binbin; Mccomb, David W.; Merad, Miriam; Brown, Brian D.; Abcdefg, Yizhou Dong; Murphy, Catherine
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Current treatment options for diabetic wounds face challenges due to low efficacy, as well as potential side effects and the necessity for repetitive treatments. To address these issues, we report a formulation utilizing trisulfide - derived lipid nanoparticle (TS LNP) - mRNA therapy to accelerate diabetic wound healing by repairing and reprogramming the microenvironment of the wounds. A library of reactive oxygen species (ROS) - responsive TS LNPs was designed and developed to encapsulate int...
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作者：Choma, Ernani F.; Robinson, Lisa A.; Nadeau, Kari C.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
摘要：Electric school buses have been proposed as an alternative to reduce the health and climate impacts of the current U.S. school bus fleet, of which a substantial share are highly polluting old diesel vehicles. However, the climate and health benefits of electric school buses are not well known. As they are substantially more costly than diesel buses, assessing their benefits is needed to inform policy decisions. We assess the health benefits of electric school buses in the United States from re...
