22期

最新文章

• CISD3/MiNT is required for complex I function, mitochondrial integrity, and skeletal muscle maintenance AI翻译
  作者：Nechushtai, Rachel; Rowland, Linda; Karmi, Ola; Marjault, Henri- Baptiste; Nguyen, Thi Thao; Mittal, Shubham; Ahmed, Raheel S.; Grant, Deana; Manrique-Acevedo, Camila; Morcos, Faruck; Onuchic, Jose N.; Mittler, Ron
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Texas System; University of Texas Dallas; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; US Department of Veterans Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans' Hospital; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; Rice University; Rice University; Rice University; Rice University
  摘要：Mitochondria play a central role in muscle metabolism and function. A unique family of iron-sulfur proteins, termed CDGSH Iron Sulfur Domain - containing (CISD/NEET) proteins, support mitochondrial function in skeletal muscles. The abundance of these proteins declines during aging leading to muscle degeneration. Although the function of the outer mitochondrial CISD/NEET proteins, CISD1/mitoNEET and CISD2/NAF - 1, has been defined in skeletal muscle cells, the role of the inner mitochondrial CI...
• Uplift of the Puna Plateau was not limited to Miocene and younger time AI翻译
  作者：Carrapa, Barbara; Decelles, Peter G.; Dawson (nee Canavan), Robin R.; Quade, Jay; Clementz, Mark T.; Schoenbohm, Lindsay
  作者单位：University of Arizona; University of Massachusetts System; University of Massachusetts Amherst; University of Wyoming; University of Toronto; University Toronto Mississauga
• Matriglycan maintains t- tubule structural integrity in cardiac muscle AI翻译
  作者：Hord, Jeffrey M.; Anderson, Mary E.; Prouty, Sally J.; Melton, Shelly; Gastel, Zeita; Zimmerman, Kathy; Weiss, Robert M.; Campbell, Kevin P.
  作者单位：Howard Hughes Medical Institute; University of Iowa; University of Iowa; University of Iowa; University of Iowa; University of Iowa; University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System; University of Iowa
  摘要：Maintaining the structure of cardiac membranes and membrane organelles is essential for heart function. A critical cardiac membrane organelle is the transverse tubule system (called the t - tubule system) which is an invagination of the surface membrane. unique structural characteristic of the cardiac muscle t - tubule system is the extension of the extracellular matrix (ECM) from the surface membrane into the t - tubule lumen. However, the importance of the ECM extending into the cardiac t - ...
• Did private election administration funding advantage Democrats in 2020? AI翻译
  作者：Lal, Apoorva; Thompson, Daniel M.
  作者单位：University of California System; University of California Los Angeles
  摘要：Private donors contributed more than $350 million to local election officials to support the administration of the 2020 election. Supporters argue these grants were neutral and necessary to maintain normal election operations during the pandemic, while critics worry these grants mostly went to Democratic strongholds and tilted election outcomes. How much did these grants shape the 2020 presidential election? To answer this question, we collect administrative data on private election administra...
• IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota AI翻译
  作者：Roewekamp, Ivo; Maschirow, Laura; Rabes, Anne; Vernengo, Facundo Fiocca; Hamann, Lutz; Heinz, Gitta Anne; Mashreghi, Mir- Farzin; Caesar, Sandra; Milek, Miha; Fonseca, Anna Carolina Fagundes; Wienhold, Sandra - Maria; Nouailles, Geraldine; Yao, Ling; Mousavi, Soraya; Bruder, Dunja; Boehme, Julia D.; Puzianowska-Kuznicka, Monika; Beule, Dieter; Witzenrath, Martin; Loehning, Max; Klose, Christoph S. N.; Heimesaat, Markus M.; Diefenbach, Andreas; Opitz, Bastian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Otto von Guericke University; Helmholtz Association; Helmholtz-Center for Infection Research; Polish Academy of Sciences; Mossakowski Medical Research Institute of the Polish Academy of Sciences; Centre of Postgraduate Medical Education - Poland; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ)
  摘要：IL - 22 plays a critical role in defending against mucosal infections, but how IL - 22 production is regulated is incompletely understood. Here, we show that mice lacking IL - 33 or its receptor ST2 (IL - 1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild - type animals and that single - nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect of IL - 33 on S. pneumoniae infection was mediated by negative regulati...
• Puppy whines mediate maternal behavior in domestic dogs AI翻译
  作者：Massenet, Mathilde; Philippe, Romane; Pisanski, Katarzyna; Arnaud, Vincent; de Beauchesne, Lucie Barluet; Reynaud, Karine; Mathevon, Nicolas; Reby, David
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Jean Monnet; Centre National de la Recherche Scientifique (CNRS); University of Wroclaw; University of Quebec; University of Quebec Chicoutimi; Ecole Nationale Veterinaire d'Alfort (ENVA); Centre National de la Recherche Scientifique (CNRS); Universite de Tours; Institut Universitaire de France; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Universite Paris-Est-Creteil-Val-de-Marne (UPEC)
  摘要：In mammals, offspring vocalizations typically encode information about identity and body condition, allowing parents to limit alloparenting and adjust care. But how do these vocalizations mediate parental behavior in species faced with the problem of rearing not one, but multiple offspring, such as domestic dogs? Comprehensive acoustic analyses of 4,400 whines recorded from 220 Beagle puppies in 40 litters revealed litter and individual (within litter) differences in call acoustic structure. B...
• Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes AI翻译
  作者：Rose, Kevin; Jepson, Tyler; Shukla, Sankalp; Maya-Romero, Alex; Kampmann, Martin; Xu, Ke; Hurtley, James H.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：The prion - like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with Alzheimer's disease. The mechanisms of cellular uptake of tau seeds and subsequent nucleated polymerization of cytosolic tau are major questions in the field, and the potential for coupling between the entry and nucleation mechanisms has been little explored. We found that in primary astrocytes and neurons, end...
• Construction of human 3D striato- nigral assembloids to recapitulate medium spiny neuronal projection defects in Huntington's disease AI翻译
  作者：Wu, Shanshan; Hong, Yuan; Chu, Chu; Gan, Yixia; Li, Xinrui; Tao, Mengdan; Wang, Da; Hu, Hao; Zheng, Zhilong; Zhu, Qian; Han, Xiao; Zhu, Wanying; Xu, Min; Dong, Yi; Liu, Yan; Guo, Xing
  作者单位：Nanjing Medical University; Nanjing Medical University; East China Normal University; Southeast University - China; Nanjing Medical University; Nantong University
  摘要：that are mainly sent from the striatum to the midbrain substantial nigra (SN), which is essential for regulating motor behaviors. Dysfunction of the Str- SN circuitry may cause a series of motor disabilities that are associated with neurodegenerative disorders, such as Huntington's disease (HD). Although the etiology of HD is known as abnormally expanded CAG repeats of the huntingtin gene, treatment of HD remains tremendously challenging. One possible reason is the lack of effective HD model t...
• Balance between asymmetric allocation and repair of somatic damage in unicellular life forms as an ancient form of r/K selection AI翻译
  作者：Biba, Dmitry A.; Wolf, Yuri I.; Koonin, Eugene V.; Rochman, Nash D.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Oak Ridge Associated Universities; United States Department of Energy (DOE); Oak Ridge Institute for Science & Education; City University of New York (CUNY) System; City University of New York (CUNY) System
  摘要：Over the course of multiple divisions, cells accumulate diverse nongenetic, somatic damage including misfolded and aggregated proteins and cell wall defects. If the rate of damage accumulation exceeds the rate of dilution through cell growth, a dedicated mitigation strategy is required to prevent eventual population collapse. Strategies for somatic damage control can be divided into two categories, asymmetric allocation and repair, which are not, in principle, mutually exclusive. We explore a ...
• Immunology and Inflammation (vol 121, e2313070121, 2024) AI翻译
  作者：Ichimuraa, Yuki; Konishi, Risa; Iida, Tadatsune; Shobo, Miwako; Tanaka, Ryota; Kubota, Noriko; Kayama, Hisako; Takeda, Kiyoshi; Nomura, Toshifumi; Fujimoto, Manabu; Okiyama, Naoko
  作者单位：Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Tokyo Women's Medical University; University of Tsukuba; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); University of Osaka; University of Osaka; University of Osaka