22期

最新文章

• A sociocultural approach to voting: Construing voting as a duty to others predicts political interest and engagement AI翻译
  作者：Waldfogel, Hannah B.; Dittmann, Andrea G.; Birnbaum, Hannah J.
  作者单位：Princeton University; Emory University; Washington University (WUSTL)
  摘要：A representative democracy requires citizens to be politically engaged; however, a substantial portion of eligible United States voters do not vote. While structural (e.g., ease or difficulty of voting) and individual (e.g., political efficacy, civic knowledge) factors contribute to (a lack of) turnout, the present work adopts a sociocultural perspective to investigate an additional contributor: how people construe-or make sense of-the duty to vote. We examine whether, and for whom, construing...
• The Andes-Amazon-Atlantic pathway: A foundational hydroclimate system for social-ecological system sustainability AI翻译
  作者：Beveridge, Claire F.; Espinoza, Jhan-Carlo; Athayde, Simone; Correa, Sandra Bibiana; Couto, Thiago B. A.; Heilpern, Sebastian A.; Jenkins, Clinton N.; Piland, Natalia C.; Utsunomiya, Renata; Wongchuig, Sly; Anderson, Elizabeth P.
  作者单位：State University System of Florida; Florida International University; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Institut de Recherche pour le Developpement (IRD); Pontificia Universidad Catolica del Peru; State University System of Florida; Florida International University; State University System of Florida; Florida International University; Mississippi State University; Lancaster University; Cornell University; Universidade de Sao Paulo; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Laboratoire d'Etudes en Geophysique et oceanographie spatiales; Cornell University
  摘要：The Amazon River Basin's extraordinary social-ecological system is sustained by various water phases, fluxes, and stores that are interconnected across the tropical Andes mountains, Amazon lowlands, and Atlantic Ocean. This Andes-Amazon- Atlantic (AAA) pathway is a complex hydroclimatic system linked by the regional water cycle through atmospheric cir - culation and continental hydrology. Here, we aim to articu - late the AAA hydroclimate pathway as a foundational system for research, manageme...
• Astrocyte- to- microglia communication via Sema4B-Plexin-B2 modulates injury- induced reactivity of microglia AI翻译
  作者：Casden, Natania; Belzer, Vitali; El Khayari, Abdellatif; El Fatimy, Rachid; Behar, Oded
  作者单位：Hebrew University of Jerusalem; Mohammed VI Polytechnic University
  摘要：After central nervous system injury, a rapid cellular and molecular response is induced. This response can be both beneficial and detrimental to neuronal survival in the first few days and increases the risk for neurodegeneration if persistent. Semaphorin4B (Sema4B), a transmembrane protein primarily expressed by cortical astrocytes, has been shown to play a role in neuronal cell death following injury. Our study shows that after cortical stab wound injury, cytokine expression is attenuated in...
• Caenorhabditis elegans neuronal RNAi does not render other tissues refractory to RNAi AI翻译
  作者：Gahlot, Shivani; Singh, Jogender
  作者单位：Indian Institute of Science Education & Research (IISER) - Mohali
• Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx- enabled highthroughput medicinal chemistry AI翻译
  作者：Kitamura, Seiya; Lin, Ting Hui; Lee, Chang Chun David; Takamura, Akihiro; Kadam, Rameshwar U.; Zhang, Ding; Zhu, Xueyong; Dada, Lucas; Nagai, Emiko; Yu, Wenli; Yao, Yao; Sharpless, K. Barry; Wilson, Ian A.; Wolan, Dennis W.
  作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Scripps Research Institute
  摘要：Seasonal and pandemic - associated influenza strains cause highly contagious viral respiratory infections that can lead to severe illness and excess mortality. Here, we report on the optimization of our smallmolecule inhibitor F0045(S) targeting the influenza hemagglutinin (HA) stem with our Sulfur - Fluoride Exchange (SuFEx) click chemistry-based highthroughput medicinal chemistry (HTMC) strategy. A combination of SuFEx - and amide - based lead molecule diversification and structure - guided ...
• Curvature- mediated rapid extravasation and penetration of nanoparticles against interstitial fluid pressure for improved drug delivery AI翻译
  作者：Jiang, Xiaohe; Xu, Sai; Miao, Yunqiu; Huang, Kang; Wang, Bingqi; Ding, Bingwen; Zhang, Zhuan; Zhao, Zitong; Zhang, Xinxin; Shi, Xinghua; Yu, Miaorong; Tian, Falin; Gan, Yong
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Nanjing University of Chinese Medicine; Henan University; National Institute of Food & Drug Control - China
  摘要：Elevated interstitial fluid pressure (IFP) within pathological tissues (e.g., tumors, obstructed kidneys, and cirrhotic livers) creates a significant hindrance to the transport of nanomedicine, ultimately impairing the therapeutic efficiency. Among these tissues, solid tumors present the most challenging scenario. While several strategies through reducing tumor IFP have been devised to enhance nanoparticle delivery, few approaches focus on modulating the intrinsic properties of nanoparticles t...
• Solving the 250-year- old mystery of the origin and global spread of the German cockroach, Blattella germanica AI翻译
  作者：Tang, Qian; Vargo, Edward L.; Ahmad, Intan; Jiang, Hong; Varadinova, Zuzana Kotykova; Dovih, Pilot; Kim, Dongmin; Bourguignon, Thomas; Booth, Warren; Schal, Coby; Mukha, Dmitry, V; Rheindt, Frank E.; Evans, Theodore A.
  作者单位：National University of Singapore; Texas A&M University System; Texas A&M University College Station; Institute Technology of Bandung; Wuhan University; Charles University Prague; National Museum; Ashoka University; State University System of Florida; University of Florida; Okinawa Institute of Science & Technology Graduate University; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Virginia Polytechnic Institute & State University; North Carolina State University; Russian Academy of Sciences; Vavilov Institute of General Genetics; University of Western Australia
  摘要：the genus is Asian, where its closest relatives are found. To solve this paradox, we sampled genome- wide markers of 281 cockroaches from 17 countries across six continents. We confirm that B. germanica evolved from the Asian cockroach Blattella asahinai approximately 2,100 ya, probably by adapting to human settlements in India or Myanmar. Our genomic analyses reconstructed two primary global spread routes, one older, westward route to the Middle East coinciding with various Islamic dynasties ...
• Type VII secretion system extracellular protein B targets STING to evade host anti- Staphylococcus aureus immunity AI翻译
  作者：Gao, Lin; Tian, Tian; Xiong, Tingrong; Zhang, Xiaomei; Wang, Ning; Liu, Luxuan; Shi, Yun; Liu, Qiang; Lu, Dongshui; Luo, Ping; Zhang, Weijun; Cheng, Ping; Gou, Qiang; Wang, Yu; Zeng, Hao; Zhang, Xiaokai; Zou, Quanming
  作者单位：Army Medical University; Army Medical University; Sichuan University; Army Medical University; Army Medical University
  摘要：Staphylococcus aureus ( S. aureus ) can evade antibiotics and host immune defenses by persisting within infected cells. Here, we demonstrate that in infected host cells, S. aureus type VII secretion system (T7SS) extracellular protein B (EsxB) interacts with the stimulator of interferon genes (STING) protein and suppresses the inflammatory defense mechanism of macrophages during early infection. The binding of EsxB with STING disrupts the K48 - linked ubiquitination of EsxB at lysine 33, there...
• Revealing operando surface defect-dependent electrocatalytic performance of Pt at the subparticle level AI翻译
  作者：Xiao, Yi; Guo, Zhichao; Cao, Jing; Song, Ping; Yang, Bo; Xu, Weilin
  作者单位：Chinese Academy of Sciences; Changchun Institute of Applied Chemistry, CAS; Chinese Academy of Sciences; Changchun Institute of Applied Chemistry, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; ShanghaiTech University
  摘要：Understanding the operando defect-tuning performance of catalysts is critical to establish an accurate structure-activity relationship of a catalyst. Here, with the tool of single - molecule super - resolution fluorescence microscopy, by imaging intermediate CO formation/oxidation during the methanol oxidation reaction process on individual defective Pt nanotubes, we reveal that the fresh Pt ends with more defects are more active and anti - CO poisoning than fresh center areas with less defect...
• The evolution of sex roles: The importance of ecology and social environment AI翻译
  作者：Fresneau, Nolwenn; Pipoly, Ivett; Gigler, Dora; Kosztolanyi, Andrzs; Szekely, Tamzs; Liker, Andrzs
  作者单位：University of Pannonia; University of Pannonia; University of Veterinary Medicine Budapest; University of Bath; University of Debrecen; University of Debrecen
  摘要：Males and females often have different roles in reproduction, although the origin of these differences has remained controversial. Explaining the enigmatic reversed sex roles where males sacrifice their mating potential and provide full parental care is a particularly long - standing challenge in evolutionary biology. While most studies focused on ecological factors as the drivers of sex roles, recent research highlights the significance of social factors such as the adult sex ratio. To disent...