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作者：Schott, Katharina; Usher, Samuel George; Serra, Oscar; Carnevale, Vincenzo; Pless, Stephan Alexander; Chua, Han Chow
作者单位：University of Copenhagen; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Sydney; University of Sydney
摘要：The sodium (Na + ) leak channel (NALCN) is a member of the four - domain voltage - gated cation channel family that includes the prototypical voltage - gated sodium and calcium channels (Na V s and Ca V s, respectively). Unlike Na V s and Ca V s, which have four lateral fenestrations that serve as routes for lipophilic compounds to enter the central cavity to modulate channel function, NALCN has bulky residues (W311, L588, M1145, and Y1436) that block these openings. Structural data suggest th...
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作者：Shang, Hsien; Johnstone, Doug; Lizano, Susana
作者单位：Academia Sinica - Taiwan; National Research Council Canada; Universidad Nacional Autonoma de Mexico
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作者：Cai, Weidong; Young, Christina B.; Yuan, Rui; Lee, Byeongwook; Ryman, Sephira; Kim, Jeehyun; Yang, Laurice; Levine, Taylor F.; Henderson, Victor W.; Poston, Kathleen L.; Menon, Vinod
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Speech impediments are a prominent yet understudied symptom of Parkinson's disease (PD). While the subthalamic nucleus (STN) is an established clinical target for treating motor symptoms, these interventions can lead to further worsening of speech. The interplay between dopaminergic medication, STN circuitry, and their downstream effects on speech in PD is not yet fully understood. Here, we investigate the effect of dopaminergic medication on STN circuitry and probe its association with speech...
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作者：Suzuki-Tellier, Sei; Miano, Federica; Asadzadeh, Seyed Saeed; Simpson, Alastair G. B.; Kiorboe, Thomas
作者单位：Technical University of Denmark; Dalhousie University
摘要：The phagotrophic flagellates described as typical excavates have been hypothesized to be morphologically similar to the Last Eukaryotic Common Ancestor and understanding the functional ecology of excavates may therefore help shed light on the ecology of these early eukaryotes. Typical excavates are characterized by a posterior flagellum equipped with a vane that beats in a ventral groove. Here, we combined flow visualization and observations of prey capture in representatives of the three clad...
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作者：Levy, Thomas E.; Smith, Neil G.; Najjar, Mohammad; Vaknin, Yoav; Ben-Yosef, Erez
作者单位：University of California System; University of California San Diego; Tel Aviv University
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作者：Jiang, Yu; Ye, Dong; Li, Aokang; Zhang, Bo; Han, Wenhu; Niu, Xuechen; Zeng, Mingtao; Guo, Lianbo; Zhang, Guanjun; Yin, Zhouping; Huang, Yongan
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Xi'an Jiaotong University; Huazhong University of Science & Technology
摘要：Seamless integration of microstructures and circuits on three- dimensional (3D) complex surfaces is of significance and is catalyzing the emergence of many innovative 3D curvy electronic devices. However, patterning fine features on arbitrary 3D targets remains challenging. Here, we propose a facile charge- driven electrohydrodynamic 3D microprinting technique that allows micron- and even submicron- scale patterning of functional inks on a couple of 3D- shaped dielectrics via an atmospheric- p...
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作者：Martinez-Corral, Rosa; Nam, Kee-Myoung; Depace, Angela H.; Gunawardena, Jeremy
作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Yale University
摘要：The Hill functions, H-h(x) = x(h)=(1 + x(h)), have been widely used in biology for over a century but, with the exception of H-1, they have had no justification other than as a convenient fit to empirical data. Here, we show that they are the universal limit for the sharpness of any input-output response arising from a Markov process model at thermodynamic equilibrium. Models may represent arbitrary molecular complexity, with multiple ligands, internal states, conformations, coregulators, etc,...
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作者：Maso, Lorenzo; Rajak, Epsa; Bang, Injin; Koide, Akiko; Hattori, Takamitsu; Neel, Benjamin G.; Koide, Shohei
作者单位：New York University; New York University; New York University
摘要：The HapImmune TM platform exploits covalent inhibitors as haptens for creating major histocompatibility complex (MHC) - presented tumor - specific neoantigens by design, combining targeted therapies with immunotherapy for the treatment of drug - resistant cancers. A HapImmune antibody, R023, recognizes multiple sotorasib - conjugated KRAS(G12C) peptides presented by different human leukocyte antigens (HLAs). This high specificity to sotorasib, coupled with broad HLA - binding capability, enabl...
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作者：Mazar, Nina; Elbaek, Christian T.; Mitkidis, Panagiotis
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作者：Potter, Sarah C.; Gibbs, Bettine E.; Hammel, Forrest A.; Joiner, Cassandra M.; Paulo, Joao A.; Janetzko, John; Levine, Zebulon G.; Fei, George Q.; Haggarty, Stephen J.; Walker, Suzanne
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Saint Olaf College; Stanford University; Massachusetts Institute of Technology (MIT); Whitehead Institute
摘要：O - GlcNAc transferase (OGT) is an essential mammalian enzyme that glycosylates myriad intracellular proteins and cleaves the transcriptional coregulator Host Cell Factor 1 to regulate cell cycle processes. Via these catalytic activities as well as noncatalytic protein- protein interactions, OGT maintains cell homeostasis. OGT's tetratricopeptide repeat (TPR) domain is important in substrate recognition, but there is little information on how changing the TPR domain impacts its cellular functi...
