22期

最新文章

• Ca2+- sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress AI翻译
  作者：Chen, Wei; Motsinger, Madeline M.; Li, Jiaqian; Bohannon, Kevin P.; Ab, Phyllis I. Hanson
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Lysosomes are central players in cellular catabolism, signaling, and metabolic lation. Cellular and environmental stresses that damage lysosomal membranes compromise their function and release toxic content into the cytoplasm. Here, examine how cells respond to osmotic stress within lysosomes. Using sensitive assays of lysosomal leakage and rupture, we examine acute effects of the osmotic disruptant glycyl - L - phenylalanine 2 - naphthylamide (GPN). Our findings reveal that low concentrations...
• Modeling of spatiotemporal dynamics of ligand-coated particle flow in targeted drug delivery processes AI翻译
  作者：Goraya, Shoaib A.; Ding, Shengzhe; Miller, Ryan C.; Arif, Mariam K.; Kong, Hyunjoon; Masud, Arif
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Northwestern University; Feinberg School of Medicine; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Nanoparticles tethered with vasculature-binding epitopes have been used to deliver the drug into injured or diseased tissues via the bloodstream. However, the extent that blood flow dynamics affects nanoparticle retention at the target site after adhesion needs to be better understood. This knowledge gap potentially underlies significantly different therapeutic efficacies between animal models and humans. An experimentally validated mathematical model that accurately simulates the effects of b...
• Reply to Carrapa et al.: Central Puna uplift: Addressing criticisms, affirming conclusions AI翻译
  作者：Pingel, Heiko; Alonso, Ricardo N.; Bookhagen, Bodo; Cottle, John M.; Mulch, Andreas; Rohrmann, Alexander; Strecker, Manfred R.
  作者单位：University of Potsdam; University of California System; University of California Santa Barbara; Goethe University Frankfurt; Free University of Berlin
• Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N- heptad repeat and their use as HIV-1 vaccine candidates AI翻译
  作者：Wu, Chengwei; Raheem, Izzat T.; Nahas, Debbie D.; Citron, Michael; Kim, Peter S.; Montefiori, David C.; Ottinger, Elizabeth A.; Hepler, Robert W.; Hrin, Renee; Patel, Sangita B.; Soisson, Stephen M.; Joyce, Joseph G.
  作者单位：Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Duke University; Merck & Company; Merck & Company USA; Stanford University; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); Johnson & Johnson; Janssen Pharmaceuticals
  摘要：Efforts to develop an HIV - 1 vaccine include those focusing on conserved structural elements as the target of broadly neutralizing monoclonal antibodies. MAb D5 binds to a highly conserved hydrophobic pocket on the gp41 N- heptad repeat (NHR) coiled coil and neutralizes through prevention of viral fusion and entry. Assessment of 17-mer and 36-mer NHR peptides presenting the D5 epitope in rodent immunogenicity studies showed that the longer peptide elicited higher titers of neutralizing antibo...