27期

最新文章

• The DNA damage response of Escherichia coli, revisited: Differential gene expression after replication inhibition AI翻译
  作者：Sass, Thalia H.; Lovett, Susan T.
  作者单位：Brandeis University; Brandeis University
  摘要：In 1967, in this journal, Evelyn Witkin proposed the existence of a coordinated DNA damage response in Escherichia coli , which later came to be called the SOS response. We revisited this response using the replication inhibitor azidothymidine (AZT) and RNA - Seq analysis and identified several features. We confirm the induction of classic Save our ship (SOS) loci and identify several genes, including many of the pyrimidine pathway, that have not been previously demonstrated to be DNA damage -...
• Structural insights into the regulation of RyR1 by S100A1 AI翻译
  作者：Weninger, Gunnar; Miotto, Marco C.; Tchagou, Carl; Reiken, Steven; Dridi, Haikel; Brandenburg, Soeren; Riedemann, Gabriel C.; Yuan, Qi; Liu, Yang; Chang, Alexander; Wronska, Anetta; Lehnart, Stephan E.; Marks, Andrew R.
  作者单位：Columbia University; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen
  摘要：S100A1, a small homodimeric EF - hand Ca 2+ - binding protein ( - 21 kDa), plays an important regulatory role in Ca 2+ signaling pathways involved in various biological functions including Ca 2+ cycling and contractile performance in skeletal and cardiac myocytes. One key target of the S100A1 interactome is the ryanodine receptor (RyR), a huge homotetrameric Ca 2+ release channel ( - 2.3 MDa) of the sarcoplasmic reticulum. Here, we report cryoelectron microscopy structures of S100A1 bound to R...
• Gate-tunable subband degeneracy in semiconductor nanowires AI翻译
  作者：Wang, Yuhao; Song, Wenyu; Cao, Zhan; Yu, Zehao; Yang, Shuai; Li, Zonglin; Gao, Yichun; Li, Ruidong; Chen, Fangting; Geng, Zuhan; Yang, Lining; Xu, Jiaye; Wang, Zhaoyu; Zhang, Shan; Feng, Xiao; Wang, Tiantian; Zang, Yunyi; Li, Lin; Shang, Runan; Xue, Qi-Kun; Liu, Dong E.; He, Ke; Zhang, Hao
  作者单位：Tsinghua University; Beijing Academy of Quantum Information Sciences; Hefei National Laboratory; Southern University of Science & Technology
  摘要：Degeneracy and symmetry have a profound relation in quantum systems. Here, we report gate -tunable subband degeneracy in PbTe nanowires with a nearly symmetric cross-sectional shape. The degeneracy is revealed in electron transport by the absence of a quantized plateau. Utilizing a dual gate design, we can apply an electric field to lift the degeneracy, reflected as emergence of the plateau. This degeneracy and its tunable lifting were challenging to observe in previous nanowire experiments, p...
• The biophysical landscape of viral evolution AI翻译
  作者：Wilke, Claus O.
  作者单位：University of Texas System; University of Texas Austin
• Thermoelectricity, metallic liquidity, and magnetohydrodynamics AI翻译
  作者：Behnia, Kamran
  作者单位：Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
• TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho- tau- burdened neurons AI翻译
  作者：Zubia, Mario V.; Yong, Adeline J. H.; Holtz, Kristen M.; Huang, Eric J.; Jan, Yuh Nung; Bcd, Lily Y. Jan
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco
  摘要：TMEM16F is a calcium - activated phospholipid scramblase and nonselective ion channel, which allows the movement of lipids bidirectionally across the plasma membrane. While the functions of TMEM16F have been extensively characterized in multiple cell types, the role of TMEM16F in the central nervous system remains largely unknown. Here, we sought to study how TMEM16F in the brain may be involved in neurodegeneration. Using a mouse model that expresses the pathological P301S human tau (PS19 mou...
• Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics AI翻译
  作者：DeSpenza Jr, Tyrone; Singh, Amrita; Allington, Garrett; Zhao, Shujuan; Lee, Junghoon; Kiziltug, Emre; Prina, Mackenzi L.; Desmet, Nicole; Dang, Huy Q.; Fields, Jennifer; Nelson-Williams, Carol; Zhang, Junhui; Mekbib, Kedous Y.; Dennis, Evan; Mehta, Neel H.; Duy, Phan Q.; Shimelis, Hermela; Walsh, Lauren K.; Marlier, Arnaud; Deniz, Engin; Lake, Evelyn M. R.; Constable, R. Todd; Hoffman, Ellen J.; Lifton, Richard P.; Gulledge, Allan; Fiering, Steven; Moreno-De-Luca, Andres; Haider, Shozeb; Alper, Seth L.; Jin, Sheng Chih; Kahle, Kristopher T.; Luikart, Bryan W.
  作者单位：Yale University; Yale University; Yale University; Yale University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Washington University (WUSTL); Dartmouth College; Dartmouth College; Yale University
  摘要：Enlargement of the cerebrospinal fluid (CSF)-filled brain ventricles (cerebral ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly recognized among patients with autism spectrum disorders (ASD). KATNAL2, a member of Katanin family microtubule - severing ATPases, is a known ASD risk gene, but its roles in human brain development remain unclear. Here, we show that nonsense truncation of Katnal2 ( Katnal2 Delta 17 ) in mice results in classic ciliopathy pheno...
• Quantifying NOx point sources with Landsat and Sentinel-2 satellite observations of NO2 plumes AI翻译
  作者：Varon, Daniel J.; Jervis, Dylan; Pandey, Sudhanshu; Gallardo, Sebastian L.; Balasus, Nicholas; Yang, Laura Hyesung; Jacob, Daniel J.
  作者单位：Harvard University; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
  摘要：We show that the Landsat and Sentinel - 2 satellites can detect NO 2 plumes from large point sources at 10 to 60 m pixel resolution in their blue and ultrablue bands. We use the resulting NO 2 plume imagery to quantify nitrogen oxides (NO x ) emission rates for several power plants in Saudi Arabia and the United States, including a 13 - y analysis of 132 Landsat plumes from Riyadh power plant 9 from 2009 through 2021. NO 2 in the plumes initially increases with distance from the source, likely...
• Learning dynamical systems from data: An introduction to physics-guided deep learning AI翻译
  作者：Yu, Rose; Wang, Rui
  作者单位：University of California System; University of California San Diego; Massachusetts Institute of Technology (MIT)
  摘要：Modeling complex physical dynamics is a fundamental task in science and engineering. Traditional physics-based models are first-principled, explainable, and sampleefficient. However, they often rely on strong modeling assumptions and expensive numerical integration, requiring significant computational resources and domain expertise. While deep learning (DL) provides efficient alternatives for modeling complex dynamics, they require a large amount of labeled training data. Furthermore, its pred...
• Are turbulence effects on droplet collision-coalescence a key to understanding observed rain formation in clouds? AI翻译
  作者：Chandrakar, Kamal Kant; Morrison, Hugh; Grabowski, Wojciech W.; Lawson, R. Paul
  摘要：Rain formation is a critical factor governing the lifecycle and radiative forcing of clouds and therefore it is a key element of weather and climate. Cloud microphysics-turbulence interactions occur across a wide range of scales and are challenging to represent in atmospheric models with limited resolution. Based on past experiments and idealized numerical simulations, it has been postulated that cloud turbulence accelerates rain formation by enhancing drop collision-coalescence. We provide su...