27期

最新文章

• Mycobacterium tuberculosis Rv2224c modulates innate immune responses (vol 105, pg 264, 2008) AI翻译
  作者：Rengarajan, Jyothi; Murphy, Elissa; Park, Arnold; Krone, Cassandra L.; Hett, Erik C.; Bloom, Barry R.; Glimcher, Laurie H.; Rubin, Eric J.
• Structural determinants of ivabradine block of the open pore of HCN4 AI翻译
  作者：Saponaro, Andrea; Krumbach, Jan H.; Chaves-Sanjuan, Antonio; Sharifzadeh, Atiyeh Sadat; Porro, Alessandro; Castelli, Roberta; Hamacher, Kay; Bolognesi, Martino; DiFrancesco, Dario; Clarke, Oliver B.; Thiel, Gerhard; Moroni, Anna
  作者单位：University of Milan; Technical University of Darmstadt; Technical University of Darmstadt; Technical University of Darmstadt; University of Milan; Consiglio Nazionale delle Ricerche (CNR); Columbia University; Columbia University; NewYork-Presbyterian Hospital; Columbia University
  摘要：HCN1- 4 channels are the molecular determinants of the If/Ih current that crucially regulates cardiac and neuronal cell excitability. HCN dysfunctions lead to sinoatrial block (HCN4), epilepsy (HCN1), and chronic pain (HCN2), widespread medical conditions awaiting subtype- specific treatments. Here, we address the problem by solving the cryo- EM structure of HCN4 in complex with ivabradine, to date the only HCN- specific drug on the market. Our data show ivabradine bound inside the open pore a...
• The causal effect of mental health on labor market outcomes: The case of stress- related mental disorders following a human- made disaster AI翻译
  作者：Andersen, Signe Hald; Richmond-Rakerd, Leah S.; Moffitt, Terrie E.; Caspi, Avshalom; Glymour, Medellena M.
  作者单位：University of Michigan System; University of Michigan; Duke University; Duke University; University of London; King's College London; University of Oslo
  摘要：As disasters increase due to climate change, population density, epidemics, and technology, information is needed about postdisaster consequences for people's mental health and how stress- related mental disorders affect multiple spheres of life, including labor- market attachment. We tested the causal hypothesis that individuals who developed stress- related mental disorders as a consequence of their disaster exposure experienced subsequent weak labor- market attachment and poor work- related...
• Superior sodiophilicity and molecule crowding of crown ether boost the electrochemical performance of all- climate sodium- ion batteries AI翻译
  作者：Yao, Qian; Zheng, Cheng; Ji, Deluo; Du, Yingzhe; Su, Jie; Wang, Nana; Yang, Jian; Dou, Shixue; Qian, Yitai
  作者单位：Shandong University; University of Wollongong; University of Shanghai for Science & Technology
  摘要：Sodium - ion batteries (SIBs) as one of the promising alternatives to lithium - ion batteries have achieved remarkable progress in the past. However, the all - climate performance is still very challenging for SIBs. Herein, 15 - Crown - 5 (15 - C - 5) is screened as an electrolyte additive from a number of ether molecules theoretically. The good sodiophilicity, high molecule rigidity, and bulky size enable it to reshape the solvation sheath and promote the anion engagement in the solvated stru...
• Advantageous early-life environments cushion the genetic risk for ischemic heart disease AI翻译
  作者：Baker, Samuel; Biroli, Pietro; van Kippersluis, Hans; von Hinke, Stephanie
  作者单位：University of Bristol; University of Bologna; Erasmus University Rotterdam; Erasmus University Rotterdam - Excl Erasmus MC; University of London; London School Economics & Political Science
  摘要：In one of the first papers on the impact of early -life conditions on individuals' health in older age, Barker and Osmond [ Lancet , 327, 1077-1081 (1986)] show a strong positive relationship between infant mortality rates in the 1920s and ischemic heart disease in the 1970s. We merge historical data on infant mortality rates to 370,000 individual records in the UK Biobank using information on local area and year of birth. We replicate the association between the early -life infant mortality r...
• Pairing interacting protein sequences using masked language modeling AI翻译
  作者：Lupo, Umberto; Sgarbossa, Damiano; Bitbol, Anne-Florence
  作者单位：Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Institute of Bioinformatics
  摘要：Predicting which proteins interact together from amino acid sequences is an important task. We develop a method to pair interacting protein sequences which leverages the power of protein language models trained on multiple sequence alignments (MSAs), such as MSA Transformer and the EvoFormer module of AlphaFold. We formulate the problem of pairing interacting partners among the paralogs of two protein families in a differentiable way. We introduce a method called Differentiable Pairing using A...
• Subfossil bald cypress trees suggest localized, enduring effects of major climatic episodes on the Southeast Atlantic Coast of the United States (vol 122, e2421181122, 2025) AI翻译
  作者：Napora, Katharine G.; Lecher, Alanna L.; Cherkinsky, Alexander; Horan, Robert; Jacobs, Craig; Tyler, Blaine; Thompson, Victor D.
• A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation AI翻译
  作者：Kumagai, Takashi; Iwata, Arifumi; Furuya, Hiroki; Kato, Kodai; Okabe, Atsushi; Toda, Yosuke; Kanai, Mizuki; Fujimura, Lisa; Sakamoto, Akemi; Kageyama, Takahiro; Tanaka, Shigeru; Suto, Akira; Hatano, Masahiko; Kaneda, Atsushi; Nakajima, Hiroshi
  作者单位：Chiba University; Chiba University; Chiba University; Chiba University; Chiba University; Chiba University
  摘要：Asthma is a widespread airway disorder where GATA3- dependent Type- 2 helper T (Th2) cells and group 2 innate lymphoid cells (ILC2s) play vital roles. Asthma- associated single nucleotide polymorphisms (SNPs) are enriched in a region located 926- 970 kb downstream from GATA3 in the 10p14 (hG900). However, it is unknown how hG900 affects the pathogenesis of allergic airway inflammation. To investigate the roles of the asthma- associated GATA3 enhancer region in experimental allergic airway infl...
• Altered circadian rhythm, sleep, and rhodopsin 7 -dependent shade preference during diapause in Drosophila melanogaster AI翻译
  作者：Meyerhof, Geoff T.; Easwaran, Sreesankar; Bontempo, Angela E.; Montell, Craig; Montell, Denise J.
  作者单位：University of California System; University of California Santa Barbara
  摘要：To survive adverse environments, many animals enter a dormant state such as hibernation, dauer, or diapause. Various Drosophila species undergo adult reproductive diapause in response to cool temperatures and/or short day - length. While flies are less active during diapause, it is unclear how adverse environmental conditions affect circadian rhythms and sleep. Here we show that in diapause - inducing cool temperatures, Drosophila melanogaster exhibit altered circadian activity profiles, inclu...
• Post- immunotherapy CTLA-4 Ig treatment improves antitumor efficacy AI翻译
  作者：Mok, Stephen; Cobanoglu, Didem Agac; Liu, Huey; Mancuso, James J.; Allison, James P.
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
  摘要：Immune checkpoint therapies (ICT) improve overall survival of patients with cancer but may cause immune - related adverse events (irAEs) such as myocarditis. Cytotoxic T lymphocyteassociated antigen 4 immunoglobulin fusion protein (CTLA - 4 Ig), an inhibitor of T cell costimulation through CD28, reverses irAEs in animal models. However, concerns exist about potentially compromising antitumor response of ICT. In mouse tumor models, we administered CTLA - 4 Ig 1) concomitantly with ICT or 2) aft...