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作者：Lu, Fuzhi; Pausata, Francesco S. R.; Mohtadi, Mahyar
作者单位：Nanjing University; University of Quebec; University of Quebec Montreal; University of Bremen
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作者：Xiao, Zhuo-Cheng; Lin, Kevin K.; Young, Lai-Sang
作者单位：East China Normal University; East China Normal University; University of Arizona; New York University
摘要：Biologically detailed models of brain circuitry are challenging to build and simulate due to the large number of neurons, their complex interactions, and the many unknown physiological parameters. Simplified mathematical models are more tractable, but harder to evaluate when too far removed from neuroanatomy/physiology. We propose that a multiscale model, coarse-grained (CG) while preserving local biological details, offers the best balance between biological realism and computability. This pa...
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作者：Kim, Paul H.; Kim, Joonyoung R.; Tu, Yiping; Jung, Hyesoo; Jeong, J. Y. Brian; Tran, Anh P.; Presnell, Ashley; Young, Stephen G.; Fong, Loren G.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：nuclear membrane (NM) ruptures and blebs, but the mechanisms are unclear. We susHigh- resolution microscopy of smooth muscle cells (SMCs) revealed that lamin A and lamin B1 form independent meshworks with uniformly spaced openings (-0.085 mu m2). The expression of progerin in SMCs resulted in the formation of an irregular meshwork with clusters of large openings (up to 1.4 mu m2). The expression of progerin acted in a dominant- negative fashion to disrupt the morphology of the endogenous lamin...
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作者：Bao, Shu-Jin; Zou, Yan; Zhang, Hai-Ning; Jin, Guo-Xin
作者单位：Fudan University
摘要：Although mechanically interlocked molecules (MIMs) display unique properties and functions associated with their intricate connectivity, limited assembly strategies are available for their synthesis. Herein, we presented a synergistic assembly strategy based on coordination and noncovalent interactions (pi-pi stacking and CH & ctdot;pi interactions) to selectively synthesize molecular closed three- link chains ( 631 links), highly entangled figure- eight knots ( 41 knots), trefoil knot ( 31 kn...
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作者：Ghio, Davide; Dandi, Yatin; Krzakala, Florent; Zdeborova, Lenka
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Recent years witnessed the development of powerful generative models based on flows, diffusion, or autoregressive neural networks, achieving remarkable success in generating data from examples with applications in a broad range of areas. A theoretical analysis of the performance and understanding of the limitations of these methods remain, however, challenging. In this paper, we undertake a step in this direction by analyzing the efficiency of sampling by these methods on a class of problems w...
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作者：Martin, Jonathan; Mateos, Marcos Lequerica; Onuchic, Jose N.; Coluzza, Ivan; Morcos, Faruck
作者单位：University of Texas System; University of Texas Dallas; BCMaterials; Rice University; Rice University; Rice University; Rice University; Basque Foundation for Science; University of Texas System; University of Texas Dallas
摘要：Machine learning has been proposed as an alternative to theoretical modeling when dealing with complex problems in biological physics. However, in this perspective, we argue that a more successful approach is a proper combination of these two methodologies. We discuss how ideas coming from physical modeling neuronal processing led to early formulations of computational neural networks, e.g., Hopfield networks. We then show how modern learning approaches like Potts models, Boltzmann machines, a...
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作者：Washington, Stuart D.; Shattuck, Kyle; Steckel, Jan; Peremans, Herbert; Jonckers, Elisabeth; Hinz, Rukun; Venneman, Tom; Van den Berg, Monica; Van Ruijssevelt, Lisbeth; Verellen, Thomas; Pritchett, Dominique L.; Scholliers, Jan; Liang, Sayuan; Wang, Paul C.; Verhoye, Marleen; Esser, Karl-Heinz; Van der Linden, Annemie; Keliris, Georgios A.
作者单位：University of Antwerp; Massachusetts Institute of Technology (MIT); Howard University; Howard University; Georgetown University; Georgetown University; University of Antwerp; University of Antwerp; University of Antwerp; Howard University; University of Antwerp; University of Antwerp; Fu Jen Catholic University; University of Veterinary Medicine Hannover; Foundation for Research & Technology - Hellas (FORTH); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
摘要：Echolocating bats are among the most social and vocal of all mammals. These animals are ideal subjects for functional MRI (fMRI) studies of auditory social communication given their relatively hypertrophic limbic and auditory neural structures and their reduced ability to hear MRI gradient noise. Yet, no resting - state networks relevant to social cognition (e.g., default mode - like networks or DMLNs) have been identified in bats since there are few, if any, fMRI studies in the chiropteran or...
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作者：Ahuja, Manuj; Kaidery, Navneet Ammal; Attucks, Otis C.; Mcdade, Erin; Hushpulian, Dmitry M.; Gaisin, Arsen; Gaisina, Irina; Ahn, Young Hoon; Nikulin, Sergey; Poloznikov, Andrey; Gazaryan, Irina; Yamamoto, Masayuki; Matsumoto, Mitsuyo; Igarashi, Kazuhiko; Sharma, Sudarshana M.; Thomas, Bobby
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作者：Wu, Fan; Huang, Yan; Yang, Guokun; Ye, Sheng; Mukamel, Shaul; Jiang, Jun
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui University; University of California System; University of California Irvine
摘要：Dynamic protein structures are crucial for deciphering their diverse biological functions. Two- dimensional infrared (2DIR) spectroscopy stands as an ideal tool for tracing rapid conformational evolutions in proteins. However, linking spectral characteristics to dynamic structures poses a formidable challenge. Here, we present a pretrained machine learning model based on 2DIR spectra analysis. This model has learned signal features from approximately 204,300 spectra to establish a spectrum- st...
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作者：Apte, Reema A.; Smidler, Andrea L.; Pai, James J.; Chow, Martha L.; Chen, Sanle; Mondal, Agastya; Sanchez, C. Hector M.; Antoshechkin, Igor; Marshall, John M.; Akbari, Omar S.
作者单位：University of California System; University of California San Diego; University of California System; University of California Berkeley; University of California System; University of California Berkeley; California Institute of Technology; University of California System; University of California Berkeley
摘要：Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is considered essential to curtail malaria transmission. However, existing vector control technologies rely on insecticides, which are becoming increasingly ineffective. Sterile insect technique (SIT) is a powerful suppression approach that has successfully eradicated a number of insect pests, yet the A. gambiae toolkit lacks the requisite technologies for its implementation. SIT relies on iterative mass releases...
