27期

最新文章

• U4 snRNP inhibits premature cleavage and polyadenylation of pre- mRNAs AI翻译
  作者：Feng, Qiumin; Zhao, Danhui; Lin, Zejin; Li, Mengzhao; Xiang, Andy Peng; Ye, Congting; Yao, Chengguo
  作者单位：Sun Yat Sen University; Xiamen University; Sun Yat Sen University; Sun Yat Sen University
  摘要：The essential role of U4 snRNP in pre - messenger RNA (mRNA) splicing has been well established. In this study, we utilized an antisense morpholino oligonucleotide (AMO) specifically targeting U4 snRNA to achieve functional knockdown of U4 snRNP in HeLa cells. Our results showed that this knockdown resulted in global intronic premature cleavage and polyadenylation (PCPA) events, comparable to the effects observed with U1 AMO treatment, as demonstrated by mRNA 3 '- seq analysis. Furthermore, ou...
• A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies AI翻译
  作者：Gilormini, Pierre-Andre; Thota, V. Narasimharao; Fers-Lidou, Anthony; Ashmus, Roger A.; Nodwell, Matthew; Brockerman, Jacob; Kuo, Chu-Wei; Wang, Yang; Gray, Taylor E.; Nitin; McDonagh, Anthony W.; Guu, Shih-Yun; Ertunc, Nursah; Yeo, Dominick; Zandberg, Wesley F.; Khoo, Kay-Hooi; Britton, Robert; Vocadlo, David J.
  作者单位：Simon Fraser University; Academia Sinica - Taiwan; University of British Columbia; Simon Fraser University
  摘要：The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest. One area where inhibitors of fucosylation have gained significant attention is in the production of afucosylated antibodies, which exhibit superior antibody- dependent cell cytotoxicity as compared to their fucosylated counterparts. Here, we describe P-carbafucose, a fucose derivative in which the e...
• A computational account of transsaccadic attentional allocation based on visual gain fields AI翻译
  作者：Harrison, William J.; Stead, Imogen; Wallis, Thomas S. A.; Bex, Peter J.; Mattingley, Jason B.
  作者单位：University of the Sunshine Coast; University of Queensland; University of Queensland; Technical University of Darmstadt; Technical University of Darmstadt; Philipps University Marburg; Northeastern University; Canadian Institute for Advanced Research (CIFAR)
  摘要：Coordination of goal - directed behavior depends on the brain's ability to recover the locations of relevant objects in the world. In humans, the visual system encodes the spatial organization of sensory inputs, but neurons in early visual areas map objects according to their retinal positions, rather than where they are in the world. How the brain computes world - referenced spatial information across eye movements has been widely researched and debated. Here, we tested whether shifts of cove...
• Representations and generalization in artificial and brain neural networks AI翻译
  作者：Li, Qianyi; Sorscher, Ben; Sompolinsky, Haim
  作者单位：Harvard University; Harvard University; Stanford University; Hebrew University of Jerusalem
  摘要：Humans and animals excel at generalizing from limited data, a capability yet to be fully replicated in artificial intelligence. This perspective investigates generalization in biological and artificial deep neural networks (DNNs), in both in-distribution and out-of-distribution contexts. We introduce two hypotheses: First, the geometric properties of the neural manifolds associated with discrete cognitive entities, such as objects, words, and concepts, are powerful order parameters. They link ...
• Collective Hall current in chiral active fluids: Coupling of phase and mass transport through traveling bands AI翻译
  作者：Siebers, Frank; Bebon, Robin; Jayaram, Ashreya; Speck, Thomas
  作者单位：Johannes Gutenberg University of Mainz; University of Stuttgart
  摘要：Active fluids composed of constituents that are constantly driven away from thermal equilibrium can support spontaneous currents and can be engineered to have unconventional transport properties. Here, we report the emergence of (meta)stable traveling bands in computer simulations of aligning circle swimmers. These bands are different from polar flocks and, through coupling phase with mass transport, induce a bulk particle current with a component perpendicular to the propagation direction, th...
• Reply to Lu et al.: Robust Intertropical Convergence Zone variability reconstructed from Maritime Continent speleothem δ18O records AI翻译
  作者：Yuan, Shufang; Chiang, Hong-Wei; Liu, Guangxin; Bijaksana, Satria; He, Shaoneng; Jiang, Xiuyang; Imran, Andi M.; Wicaksono, Satrio A.; Wang, Xianfeng
  作者单位：Nanyang Technological University; Nanyang Technological University; National Taiwan University; Yunnan University; Institute Technology of Bandung; Fujian Normal University; Universitas Hasanuddin; Brown University
• Carbonate uranium isotopes record global expansion of marine anoxia during the Toarcian Oceanic Anoxic Event AI翻译
  作者：Remirez, Mariano N.; Gilleaudeau, Geoffrey J.; Gan, Tian; Kipp, Michael A.; Tissot, Francois L. H.; Kaufman, Alan J.; Parente, Mariano
  作者单位：George Mason University; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; Duke University; California Institute of Technology; University of Naples Federico II
  摘要：The Toarcian Oceanic Anoxic Event (T-OAE; similar to 183 Mya) was a globally significant carbon-cycle perturbation linked to widespread deposition of organic-rich sediments, massive volcanic CO2 release, marine faunal extinction, sea-level rise, a crisis in carbonate production related to ocean acidification, and elevated seawater temperatures. Despite recognition of the T-OAE as a potential analog for future ocean deoxygenation, current knowledge on the severity of global ocean anoxia is limi...
• Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons AI翻译
  作者：Qiu, Haoyi; Miraucourt, Lois S.; Petitjean, Hugues; Xu, Mengyi; Theriault, Catherine; Davidova, Albena; Soubeyre, Vanessa; Poulen, Gaetan; Lonjon, Nicolas; Vachiery-Lahaye, Florence; Bauchet, Luc; Levesque-Damphousse, Philipa; Estall, Jennifer L.; Bourinet, Emmanuel; Sharif-Naeini, Reza
  作者单位：McGill University; McGill University; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; CHU de Montpellier; Universite de Montpellier; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM)
  摘要：Spinal cord dorsal horn inhibition is critical to the processing of sensory inputs, and its impairment leads to mechanical allodynia. How this decreased inhibition occurs and whether its restoration alleviates allodynic pain are poorly understood. Here, we show that a critical step in the loss of inhibitory tone is the change in the firing pattern of inhibitory parvalbumin (PV)- expressing neurons (PVNs). Our results show that PV, a calcium- binding protein, controls the firing activity of PVN...
• Psychosocial experiences are associated with human brain mitochondrial biology AI翻译
  作者：Trumpff, Caroline; Monzel, Anna S.; Sandi, Carmen; Menon, Vilas; Klein, Hans - Ulrich; Fujita, Masashi; Lee, Annie; Petyuk, Vladislav A.; Hurst, Cheyenne; Duong, Duc M.; Seyfried, Nicholas T.; Wingo, Aliza P.; Wingo, Thomas S.; Wang, Yanling; Thambisetty, Madhav; Ferrucci, Luigi; Bennett, David A.; Jager, Philip L. De; Picard, Martin
  作者单位：Columbia University; NewYork-Presbyterian Hospital; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; NewYork-Presbyterian Hospital; Columbia University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Emory University; Emory University; Rush University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Columbia University; NewYork-Presbyterian Hospital; New York State Psychiatry Institute; Columbia University
  摘要：Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain function relies on energy transformation by mitochondria oxidative phosphorylation (OxPhos). Two main lines of evidence position mitochondria both as targets and drivers of psychosocial experiences. On the one hand, chronic stress exposure and mood states may alter multiple aspects of mitochondrial biology; on the other hand, functional vari...
• Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel AI翻译
  作者：Karuppan, Sebastian; Schrag, Lynn Goss; Pastrano, Caroline M.; Jara-Oseguera, Andres; Zubcevic, Lejla
  作者单位：University of Kansas; University of Kansas Medical Center; University of Texas System; University of Texas Austin; Arizona State University; Arizona State University-Tempe
  摘要：The transient receptor potential melastatin (TRPM) tetrameric cation channels are involved in a wide range of biological functions, from temperature sensing and taste transduction to regulation of cardiac function, inflammatory pain, and insulin secretion. The structurally conserved TRPM cytoplasmic domains make up >70 % of the total protein. To investigate the mechanism by which the TRPM cytoplasmic domains contribute to gating, we employed electrophysiology and cryo-EM to study TRPM5-a chann...