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作者：Otani, Masahiko; Tojo, Ryo; Regnard, Sarah; Zheng, Lipeng; Hoshi, Takumi; Ohmori, Suzuha; Tachibana, Natsuki; Sano, Tomohiro; Koshimizu, Shizuka; Ichimura, Kazuya; Colcombet, Jean; Kawakami, Naoto; Shinozaki, Kazuo
作者单位：Meiji University; Meiji University; Universite Paris Saclay; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Kagawa University
摘要：The timing of seed germination is controlled by the combination of internal dormancy and external factors. Temperature is a major environmental factor for seed germination. The permissive temperature range for germination is narrow in dormant seeds and expands during after- ripening (AR) (dormancy release). Quantitative trait loci analyses of preharvest sprouting in cereals have revealed that MKK3, a mitogen- activated protein kinase (MAPK) cascade protein, is a negative regulator of grain dor...
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作者：Small, Mario L.
作者单位：Columbia University
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作者：Yang, Runzhao; Xiao, Tingxiong; Cheng, Yuxiao; Li, Anan; Qu, Jinyuan; Liang, Rui; Bao, Shengda; Wang, Xiaofeng; Wang, Jue; Suo, Jinli; Luo, Qingming; Dai, Qionghai
作者单位：Tsinghua University; Tsinghua University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Hainan University
摘要：Efficient storage and sharing of massive biomedical data would open up their wide accessibility to different institutions and disciplines. However, compressors tailored for natural photos/videos are rapidly limited for biomedical data, while emerging deep learning-based methods demand huge training data and are difficult to generalize. Here, we propose to conduct Biomedical data compRession with Implicit nEural Function (BRIEF) by representing the target data with compact neural networks, whic...
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作者：Basaglia, Piero; Grunau, Jonas; Drupp, Moritz A.
作者单位：University of Hamburg; Universite de Bordeaux; Max Planck Society; University of Hamburg; Leibniz Association; Ifo Institut; University of Gothenburg
摘要：Mitigating greenhouse gas emissions and reducing air pollution represent two pressing and interwoven environmental challenges. While international carbon markets, such as the European Union emissions trading system (EU ETS), have demonstrated their effectiveness in curbing carbon emissions (CO 2 ), their indirect impact on hazardous copollutants remains understudied. This study investigates how key toxic air pollutants- sulfur dioxide (SO 2 ), fine particulate matter (PM 2 . 5 ), and nitrogen ...
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作者：Feng, Li - Li; Bie, Shu - Ying; Deng, Zhi - Heng; Bai, Shao - Mei; Shi, Jie; Qin, Cao - Litao; Liu, Huan - Lei; Li, Jia - Xu; Chen, Wan - Ying; Zhou, Jin - Ying; Jiao, Chun - Mei; Ma, Yi; Qiu, Meng - Bo; Ai, Hua - Song; Zheng, Jian; Hung, Mien - Chie; Wang, Yun- Long; Wan, Xiang- Bo; Fan, Xin- Juan
作者单位：Zhengzhou University; Zhengzhou University; State Key Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Tsinghua University; Sun Yat Sen University; Sun Yat Sen University; Zhengzhou University; Zhengzhou University; China Medical University Taiwan; China Medical University Taiwan
摘要：Rapid accumulation of repair factors at DNA double- strand breaks (DSBs) is essential for DSB repair. Several factors involved in DSB repair have been found undergoing liquid-liquid phase separation (LLPS) at DSB sites to facilitate DNA repair. RNF168, a RING- type E3 ubiquitin ligase, catalyzes H2A.X ubiquitination for recruiting DNA repair factors. Yet, whether RNF168 undergoes LLPS at DSB sites remains unclear. Here, we identified K63linked polyubiquitin- triggered RNF168 condensation which...
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作者：Lynch, Michael; Wei, Wen; Ye, Zhiqiang; Pfrender, Michael
作者单位：Arizona State University; Arizona State University-Tempe; Central China Normal University; University of Notre Dame
摘要：Despite evolutionary biology's obsession with natural selection, few studies have evaluated multigenerational series of patterns of selection on a genome-wide scale in natural populations. Here, we report on a 10-y population-genomic survey of the microcrustacean Daphnia pulex. The genome sequences of>800 isolates provide insights into patterns of selection that cannot be obtained from long-term molecular-evolution studies, including the following: the pervasiveness of near quasi-neutrality ac...
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作者：Wu, Qinghua; Rafatian, Naimeh; Wagner, Karl T.; Blamer, Jacob; Smith, Jacob; Okhovatian, Sargol; Aggarwal, Praful; Wang, Erika Yan; Banerjee, Arinjay; Zhao, Yimu; Nash, Trevor R.; Lu, Rick Xing Ze; Portillo-Esquivel, Luis Eduardo; Li, Chen Yu; Kuzmanov, Uros; Mandla, Serena; Virlee, Elizabeth; Landau, Shira; Black, Lauren D.; Griffin, Diane E.; Lai, Benjamin Fook; Gramolini, Anthony O.; Liu, Chuan; Fleischer, Sharon; Veres, Teodor; Vunjak-Novakovic, Gordana; Zhang, Boyang; Mossman, Karen; Broeckel, Ulrich; Radisic, Milica
作者单位：University of Toronto; University of Toronto; University Health Network Toronto; Toronto General Hospital; University of Toronto; University of Toronto; Medical College of Wisconsin; McMaster University; University of Saskatchewan; Columbia University; McMaster University; University of Toronto; University of Toronto; National Research Council Canada; University of Toronto; Columbia University
摘要：Adverse cardiac outcomes in COVID- 19 patients, particularly those with preexisting cardiac disease, motivate the development of human cell- based organ- on- a- chip models to recapitulate cardiac injury and dysfunction and for screening of cardioprotective therapeutics. Here, we developed a heart- on- a- chip model to study the pathogenesis of SARS- CoV- 2 in healthy myocardium established from human induced pluripotent stem cell (iPSC)- derived cardiomyocytes and a cardiac dysfunction model,...
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作者：Astigarraga, Julen; Esquivel-Muelbert, Adriane; Ruiz-Benito, Paloma; Rodriguez-Sanchez, Francisco; Zavala, Miguel A.; Vila-Cabrera, Albert; Schelhaas, Mart-Jan; Kunstler, Georges; Woodall, Christopher W.; Cienciala, Emil; Dahlgren, Jonas; Govaere, Leen; Koenig, Louis A.; Lehtonen, Aleksi; Talarczyk, Andrzej; Liu, Daijun; Pugh, Thomas A. M.
作者单位：Universidad de Alcala; University of Birmingham; University of Birmingham; Universidad de Alcala; University of Sevilla; Universidad de Alcala; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Wageningen University & Research; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); INRAE; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences; Swedish University of Agricultural Sciences; Swiss Federal Institutes of Technology Domain; ETH Zurich; Natural Resources Institute Finland (Luke); University of Vienna; Lund University
摘要：Although climate change is expected to drive tree species toward colder and wetter regions of their distribution, broadscale empirical evidence is lacking. One possibility is that past and present human activities in forests obscure or alter the effects of climate. Here, using data from more than two million monitored trees from 73 widely distributed species, we quantify changes in tree species density within their climatic niches across Northern Hemisphere forests. We observe a reduction in m...
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作者：Petros, Brittany A.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
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作者：Yong, Ee Hou; Dary, Farisan; Giomi, Luca; Mahadevan, L.
作者单位：Nanyang Technological University; Leiden University - Excl LUMC; Leiden University; Harvard University; Harvard University; Harvard University
