-
作者：Barzon, Giacomo; Artime, Oriol; Suweis, Samir; De Domenico, Manlio
作者单位：University of Padua; Fondazione Bruno Kessler; University of Barcelona; University of Barcelona; Universitat de les Illes Balears; University of Padua; Istituto Nazionale di Fisica Nucleare (INFN); University of Padua
摘要：Complex systems are characterized by emergent patterns created by the nontrivial interplay between dynamical processes and the networks of interactions on which these processes unfold. Topological or dynamical descriptors alone are not enough to fully embrace this interplay in all its complexity, and many times one has to resort to dynamics-specific approaches that limit a comprehension of general principles. To address this challenge, we employ a metric-that we name Jacobian distance- which c...
-
作者：Fu, Buli; Liang, Jinjin; Hu, Jinyu; Du, Tianhua; Tan, Qimei; He, Chao; Wei, Xuegao; Gong, Peipan; Yang, Jing; Liu, Shaonan; Huang, Mingjiao; Gui, Lianyou; Liu, Kui; Zhou, Xuguo; Nauen, Ralf; Bass, Chris; Yang, Xin; Zhang, Youjun
作者单位：Chinese Academy of Agricultural Sciences; Institute of Vegetables & Flowers, CAAS; Chinese Academy of Tropical Agricultural Sciences; Yangtze University; Hunan Academy of Agricultural Sciences; Hunan Agricultural University; University of Illinois System; University of Illinois Urbana-Champaign; Bayer AG; University of Exeter
摘要：Trade- offs between evolutionary gain and loss are prevalent in nature, yet their genetic basis is not well resolved. The evolution of insect resistance to insecticide is often associated with strong fitness costs; however, how the fitness trade- offs operates remains poorly understood. Here, we show that the mitogen- activated protein kinase (MAPK) pathway and its upstream and downstream actors underlie the fitness trade- offs associated with insecticide resistance in the whitefly Bemisia tab...
-
作者：Natarajan, Chandramohan; Le, Linh H. D.; Gunasekaran, Manojkumar; Tracey, Kevin J.; Chernoff, David; Levine, Yaakov A.
作者单位：Northwell Health; Northwell Health; Northwell Health; Karolinska Institutet; Karolinska University Hospital; Novartis; Novartis USA
摘要：Multiple sclerosis (MS) is a demyelinating central nervous system (CNS) disorder that is associated with functional impairment and accruing disability. There are multiple U.S. Food and Drug Administration (FDA)- approved drugs that effectively dampen inflammation and slow disability progression. However, these agents do not work well for all patients and are associated with side effects that may limit their use. The vagus nerve (VN) provides a direct communication conduit between the CNS and t...
-
作者：Zdrzalek, Rafal; Xi, Yuxuan; Langner, Thorsten; Bentham, Adam R.; Houdenot, Yohann Petit-; De la Concepcion, Juan Carlos; Harant, Adeline; Shimizu, Motoki; Were, Vincent; Talbot, Nicholas J.; Terauchi, Ryohei; Kamoun, Sophien; Banfield, Mark J.
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of East Anglia; Iwate Biotechnology Research Center; Kyoto University; Max Planck Society; Universite Paris Saclay; INRAE; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
摘要：Bioengineering of plant immune receptors has emerged as a key strategy for generating novel disease resistance traits to counteract the expanding threat of plant pathogens to global food security. However, current approaches are limited by rapid evolution of plant pathogens in the field and may lack durability when deployed. Here, we show that the rice nucleotidebinding, leucine- rich repeat (NLR) immune receptor Pik- 1 can be engineered to respond to a conserved family of effectors from the m...
-
作者：Brahmachari, Sumitabha; Tripathi, Shubham; Onuchic, Jose N.; Levine, Herbert
作者单位：Rice University; Rice University; Rice University; Rice University; Rice University; Northeastern University; Northeastern University; Yale University; Yale University
摘要：Transcription has a mechanical component, as the translocation of the transcription machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically coupled to the chromatin torsion. This posits chromatin mechanics as a possible regulator of eukaryotic transcription, however, the modes and mechanisms of this regulation are elusive. Here, we first take a statistical mechanics approach to model the torsional response of topology-constrained chromatin. Our model recapitulates the experimenta...
-
作者：Zhou, Qiyin; Yu, Hongfei; Chen, Yongxia; Ren, Jiayi; Lu, Yan; Sun, Yi
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
摘要：SLC7A11 is a cystine transporter and ferroptosis inhibitor. How the stability of SLC7A11 is coordinately regulated in response to environmental cystine by which E3 ligase and deubiquitylase (DUB) remains elusive. Here, we report that neddylation inhibitor MLN4924 increases cystine uptake by causing SLC7A11 accumulation, via inactivating Cullin-RING ligase-3 (CRL-3). We identified KCTD10 as the substrate- recognizing subunit of CRL-3 for SLC7A11 ubiquitylation, and USP18 as SLC7A11 deubiquityla...
-
作者：Gluck, Chaim; Zhou, Quanyu; Droux, Jeanne; Chen, Zhenyue; Glandorf, Lukas; Wegener, Susanne; Razansky, Daniel; Weber, Bruno; El Amki, Mohamad
作者单位：University of Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University Zurich Hospital; University of Zurich
摘要：The pial vasculature is the sole source of blood supply to the neocortex. The brain is contained within the skull, a vascularized bone marrow with a unique anatomical connection to the brain meninges. Recent developments in tissue clearing have enabled detailed mapping of the entire pial and calvarial vasculature. However, what are the absolute flow rate values of those vascular networks? This information cannot accurately be retrieved with the commonly used bioimaging methods. Here, we introd...
-
作者：Torres, Mariela C.; Rebok, Abbey; Sun, Dongxiao; Spratt, Thomas E.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; University of North Carolina; University of North Carolina Chapel Hill
摘要：DNA polymerase kappa (Pol kappa ) is a specialized polymerase that has multiple cellular roles such as translesion DNA synthesis, replication of repetitive sequences, and nucleotide excision repair. We have developed a method for capturing DNA synthesized by Pol kappa utilizing a Pol kappa -specific substrate, N 2- (4- ethynylbenzyl)- 2 '- deoxyguanosine (EBndG). After shearing of the DNA into 200 to 500 bp lengths, the EBndG- containing DNA was covalently bound to biotin using the Cu(I)- cata...
-
作者：Boyce, Veronica; Hawkins, Robert D.; Goodman, Noah D.; Frank, Michael C.
作者单位：Stanford University; University of Wisconsin System; University of Wisconsin Madison; Stanford University
摘要：Real-world communication frequently requires language producers to address more than one comprehender at once, yet most psycholinguistic research focuses on one-onone communication. As the audience size grows, interlocutors face new challenges that do not arise in dyads. They must consider multiple perspectives and weigh multiple sources of feedback to build shared understanding. Here, we ask which properties of the group's interaction structure facilitate successful communication. We used a r...
-
作者：Eisner, David; Murphy, Elizabeth
作者单位：University of Manchester; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
