28期

最新文章

• Capturing alterations of intracellular-extracellular lactate distribution in the brain using diffusion- weighted MR spectroscopy in vivo AI翻译
  作者：Malaquin, Sophie; Lerchundi, Rodrigo; Mougel, Eloise; Valette, Julien
  作者单位：CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
  摘要：While the intracellular-extracellular distribution of lactate has been suggested to play a critical role in the healthy and diseased brain, tools are lacking to noninvasively probe lactate in intracellular and extracellular spaces. Here, we show that, by measuring the diffusion of lactate with diffusion- weighted magnetic resonance (MR) spectroscopy in vivo and comparing it to the diffusion of purely intracellular metabolites, noninvasive quantification of extracellular and intracellular lacta...
• A tandem activity- based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools AI翻译
  作者：Pezacki, Aidan T.; Gonciarz, Ryan L.; Okamura, Toshitaka; Matier, Carson D.; Torrente, Laura; Cheng, Ke; Miller, Sophia G.; Ralle, Martina; Ward, Nathan P.; DeNicola, Gina M.; Renslo, Adam R.; Chang, Christopher J.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California San Francisco; H Lee Moffitt Cancer Center & Research Institute; Oregon Health & Science University; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Iron is an essential element for life owing to its ability to participate in a diverse array of oxidation-reduction reactions. However, misregulation of iron- dependent redox cycling can also produce oxidative stress, contributing to cell growth, proliferation, and death pathways underlying aging, cancer, neurodegeneration, and metabolic diseases. Fluorescent probes that selectively monitor loosely bound Fe(II) ions, termed the labile iron pool, are potentially powerful tools for studies of th...
• Attenuating midline thalamus bursting to mitigate absence epilepsy AI翻译
  作者：Dong, Ping; Bakhurin, Konstantin; Li, Yuhui; Mikati, Mohamad A.; Cui, Jianmin; Grill, Warren M.; Yin, Henry H.; Yang, Huanghe
  作者单位：Duke University; Duke University; Duke University; Duke University; Duke University; Duke University
  摘要：Advancing the mechanistic understanding of absence epilepsy is crucial for developing new therapeutics, especially for patients unresponsive to current treatments. Utilizing a recently developed mouse model of absence epilepsy carrying the BK gain- of- function channelopathy D434G, here we report that attenuating the burst firing of midline thalamus (MLT) neurons effectively prevents absence seizures. We found that enhanced BK channel activity in the BK- D434G MLT neurons promotes synchronized...
• A mathematical theory of relational generalization in transitive inference AI翻译
  作者：Lippl, Samuel; Kay, Kenneth; Jensen, Greg; Ferrera, Vincent P.; Abbott, L. F.
  作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Reed College - Portland; Columbia University
  摘要：Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items. This allows them to respond appropriately to radically novel circumstances and is fundamental to advanced cognition. However, how learning systems (including the brain) can implement the necessary inductive biases has been unclear. We investigated transitive inference (TI), a classic relational task paradigm in which subjects must learn a relation ( A > ...
• Hemispheric functional organization, as revealed by naturalistic neuroimaging, in pediatric epilepsy patients with cortical resections AI翻译
  作者：Robert, Sophia; Granovetter, Michael C.; Patterson, Christina; Behrmann, Marlene
  作者单位：Carnegie Mellon University; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Functional changes in the pediatric brain following neural injuries attest to remarkable feats of plasticity. Investigations of the neurobiological mechanisms that underlie this plasticity have largely focused on activation in the penumbra of the lesion or in contralesional, homotopic regions. Here, we adopt a whole- brain approach to evaluate the plasticity of the cortex in patients with large unilateral cortical resections due to drug- resistant childhood epilepsy. We compared the functional...
• Quantum acoustics unravels Planckian resistivity AI翻译
  作者：Aydin, Alhun; Keski-Rahkonen, Joonas; Heller, Eric J.
  作者单位：Harvard University; Sabanci University; Tampere University; Harvard University
  摘要：Strange metals exhibit universal linear-in-temperature resistivity described by a Planckian scattering rate, the origin of which remains elusive. By employing an approach inspired by quantum optics, we arrive at the coherent state representation of lattice vibrations: quantum acoustics. Utilizing this nonperturbative framework, we demonstrate that lattice vibrations could serve as active drivers in the Planckian resistivity phenomenon, challenging prevailing theories. By treating charge carrie...
• Structural and mechanistic analysis of Ca2+- dependent regulation of transglutaminase 2 activity using a Ca2+- bound intermediate state AI翻译
  作者：Sewa, Agnele S.; Besser, Harrison A.; Mathews, Irimpan I.; Khosla, Chaitan
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
  摘要：Mammalian transglutaminases, a family of Ca 2+- dependent proteins, are implicated in a variety of diseases. For example, celiac disease (CeD) is an autoimmune disorder whose pathogenesis requires transglutaminase 2 (TG2) to deamidate select glutamine residues in diet- derived gluten peptides. Deamidation involves the formation of transient gamma- glutamyl thioester intermediates. Recent studies have revealed that in addition to the deamidated gluten peptides themselves, their corresponding th...
• A nanofluidic spiking synapse AI翻译
  作者：Xu, Yi-Tong; Yu, Si-Yuan; Li, Zheng; Kou, Bo-Han; Pang, Jian-Xiang; Zhao, Wei-Wei; Chen, Hong-Yuan; Xu, Jing-Juan
  作者单位：Nanjing University
  摘要：Currently, the nanofluidic synapse can only perform basic neuromorphic pulse patterns. One immediate problem that needs to be addressed to further its capability of brain- like computing is the realization of a nanofluidic spiking device. Here, we report the use of a poly(3,4- ethylenedioxythiophene) polystyrene sulfonate membrane to achieve bionic ionic current- induced spiking. In addition to the simulation of various electrical pulse patterns, our synapse could produce transmembrane ionic c...
• The mechanics of correlated variability in segregated cortical excitatory subnetworks AI翻译
  作者：Negron, Alex; Getz, Matthew P.; Handy, Gregory; Doiron, Brent
  作者单位：Illinois Institute of Technology; University of Chicago; University of Chicago; University of Chicago; Technical University of Munich; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Understanding the genesis of shared trial-to-trial variability in neuronal population activity within the sensory cortex is critical to uncovering the biological basis of information processing in the brain. Shared variability is often a reflection of the structure of cortical connectivity since it likely arises, in part, from local circuit inputs. A series of experiments from segregated networks of (excitatory) pyramidal neurons in the mouse primary visual cortex challenge this view. Specific...
• An atlas of the tomato epigenome reveals that KRYPTONITE shapes TAD- like boundaries through the control of H3K9ac distribution AI翻译
  作者：An, Jing; Chaouche, Rim Brik; Bistrain, Leonardo I. Pereyra-; Zalzale, Hugo; Wang, Qingyi; Huang, Ying; He, Xiaoning; Lopes, Chloe Dias; Sanchez, Javier Antunez-; Bergounioux, Catherine; Boulogne, Claire; Dupas, Cynthia; Gillet, Cynthia; Perez-Perez, Jose Manuel; Mathieu, Olivier; Bouche, Nicolas; Fragkostefanakis, Sotirios; Zhang, Yijing; Zheng, Shaojian; Crespi, Martin; Mahfouz, Magdy M.; Ariel, Federico; Marcos, Jose Gutierrez-; Raynaud, Cecile; Latrasse, David; Benhamed, Moussa
  作者单位：Universite Paris Cite; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); INRAE; Universite Paris Saclay; Universite Paris Cite; University of Warwick; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universidad Miguel Hernandez de Elche; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); AgroParisTech; INRAE; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Goethe University Frankfurt; Fudan University; Zhejiang University; King Abdullah University of Science & Technology; National University of the Littoral; Institut Universitaire de France
  摘要：In recent years, the exploration of genome three- dimensional (3D) conformation has yielded profound insights into the regulation of gene expression and cellular functions in both animals and plants. While animals exhibit a characteristic genome topology defined by topologically associating domains (TADs), plants display similar features with a more diverse conformation across species. Employing advanced high- throughput sequencing and microscopy techniques, we investigated the landscape of 26...