28期

最新文章

• Constraining Earth's nonlinear mantle viscosity using plate-boundary resolving global inversions AI翻译
  作者：Hu, Jiashun; Rudi, Johann; Gurnis, Michael; Stadler, Georg
  作者单位：Southern University of Science & Technology; Virginia Polytechnic Institute & State University; California Institute of Technology; New York University
  摘要：Variable viscosity in Earth's mantle exerts a fundamental control on mantle convection and plate tectonics, yet rigorously constraining the underlying parameters has remained a challenge. Inverse methods have not been sufficiently robust to handle the severe viscosity gradients and nonlinearities (arising from dislocation creep and plastic failure) while simultaneously resolving the megathrust and bending slabs globally. Using global plate motions as constraints, we overcome these challenges b...
• Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase AI翻译
  作者：Yoshida, Saishu; Kawamura, Akira; Aoki, Katsuhiko; Wiriyasermkul, Pattama; Sugimoto, Shinya; Tomiyoshi, Junnosuke; Tajima, Ayasa; Ishida, Yamato; Katoh, Yohei; Tsukada, Takehiro; Tsuneoka, Yousuke; Yamada, Kohji; Nagamori, Shushi; Nakayama, Kazuhisa; Yoshida, Kiyotsugu
  作者单位：Toho University; Hiroshima University; Jikei University; Jikei University; Jikei University; Jikei University; Jikei University; Jikei University; Jikei University; Jikei University; Kyoto University; Toho University; Toho University
  摘要：Hedgehog (Hh) signaling, an evolutionarily conserved pathway, plays an essential role in development and tumorigenesis, making it a promising drug target. Multiple negative regulators are known to govern Hh signaling; however, how activated Smoothened (SMO) participates in the activation of downstream GLI2 and GLI3 remains unclear. Herein, we identified the ciliary kinase DYRK2 as a positive regulator of the GLI2 and GLI3 transcription factors for Hh signaling. Transcriptome and interactome an...
• Spectroscopic evidence of spin- state excitation in d- electron correlated semiconductor FeSb2 AI翻译
  作者：Li, Huayao; Wang, Guohua; Ding, Ning; Ren, Quan; Zhao, Gan; Lin, Wenting; Yang, Jinchuan; Yan, Wensheng; Li, Qian; Yang, Run; Yuan, Shijun; Denlinger, Jonathan D.; Wang, Zhenxing; Zhang, Xiaoqian; Wray, L. Andrew; Dong, Shuai; Qian, Dong; Miao, Lin
  作者单位：Southeast University - China; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Huazhong University of Science & Technology; Huazhong University of Science & Technology; New York University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Shanghai Jiao Tong University
  摘要：Iron antimonide (FeSb 2 ) has been investigated for decades due to its puzzling electronic properties. It undergoes the temperature- controlled transition from an insulator to an ill- defined metal, with a cross- over from diamagnetism to paramagnetism. Extensive efforts have been made to uncover the underlying mechanism, but a consensus has yet to be reached. While macroscopic transport and magnetic measurements can be explained by different theoretical proposals, the essential spectroscopic ...
• Data- driven inverse design of flexible pressure sensors AI翻译
  作者：Liu, Zhiguang; Cai, Minkun; Hong, Shenda; Shi, Junli; Xie, Sai; Liu, Chang; Du, Huifeng; Morin, James D.; Li, Gang; Wang, Liu; Wang, Hong; Tang, Ke; Fang, Nicholas X.; Guo, Chuan Fei
  作者单位：Southern University of Science & Technology; Massachusetts Institute of Technology (MIT); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Peking University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Southern University of Science & Technology; University of Hong Kong
  摘要：Artificial skins or flexible pressure sensors that mimic human cutaneous mechanoreceptors transduce tactile stimuli to quantitative electrical signals. Conventional trial- and- error designs for such devices follow a forward structure- to- property routine, which is usually time- consuming and determines one possible solution in one run. Data- driven inverse design can precisely target desired functions while showing far higher productivity, however, it is still absent for flexible pressure se...
• METAPHOR: Metabolic evaluation through phasor-based hyperspectral imaging and organelle recognition for mouse blastocysts and oocytes AI翻译
  作者：Parra, Albert; Denkova, Denitza; Burgos-Artizzu, Xavier P.; Aroca, Ester; Casals, Marc; Godeau, Amelie; Ares, Miguel; Ferrer-Vaquer, Anna; Massafret, Ot; Oliver-Vila, Irene; Mestres, Enric; Acacio, Monica; Costa-Borges, Nuno; Rebollo, Elena; Chiang, Hsiao Ju; Fraser, Scott E.; Cutrale, Francesco; Seriola, Anna; Ojosnegros, Samuel
  作者单位：Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Biologia Molecular de Barcelona (IBMB); University of Southern California; University of Southern California; University of Southern California
  摘要：Only 30% of embryos from in vitro fertilized oocytes successfully implant and develop to term, leading to repeated transfer cycles. To reduce time-to-pregnancy and stress for patients, there is a need for a diagnostic tool to better select embryos and oocytes based on their physiology. The current standard employs brightfield imaging, which provides limited physiological information. Here, we introduce METAPHOR: Metabolic Evaluation through Phasor-based Hyperspectral Imaging and Organelle Reco...
• Mortality risk information and health-seeking behavior during an epidemic AI翻译
  作者：Purcell, Helene; Kohler, Iliana, V; Ciancio, Alberto; Mwera, James; Delavande, Adeline; Mwapasa, Victor; Kohler, Hans-Peter
  作者单位：University of Pennsylvania; University of Glasgow; Universidade Nova de Lisboa; University of Technology Sydney
  摘要：In a context where pessimistic survival perceptions have been widespread as a result of the HIV/AIDS epidemic (Fig. 1 A ), we study vaccine uptake and other health behaviors during the recent COVID-19 pandemic. Leveraging a longitudinal cohort study in rural Malawi that has been followed for up to 25 y, we document that a 2017 mortality risk information intervention designed to reduce pessimistic mortality perceptions (Fig. 1 B ) resulted in improved health behavior, including COVID-19 vaccine...
• The chronology of the human colonization of the Canary Islands AI翻译
  作者：Santana, Jonathan; del Pino, Miguel; Morales, Jacob; Fregel, Rosa; Hagenblad, Jenny; Morquecho, Aaron; Mayor, Aitor Brito-; Henriquez, Pedro; Jimenez, Jared; Serrano, Javier G.; Sanchez-Canadillas, Elias; Ordonez, Alejandra C.; Gilson, Simon- Pierre
  作者单位：Universidad de Las Palmas de Gran Canaria; Universidad de la Laguna; Linkoping University
  摘要：The human colonization of the Canary Islands represents the sole known expansion of Berber communities into the Atlantic Ocean and is an example of marine dispersal carried out by an African population. While this island colonization shows similarities to the populating of other islands across the world, several questions still need to be answered before this case can be included in wider debates regarding patterns of initial colonization and human settlement, human-environment interactions, a...
• The role of positive emotion in harmful health behavior: Implications for theory and public health campaigns AI翻译
  作者：Wang, Ke; Rees, Vaughan W.; Dorison, Charles A.; Kawachi, Ichiro; Lerner, Jennifer S.
  作者单位：Harvard University; Harvard University; Harvard T.H. Chan School of Public Health; Georgetown University; Harvard University
  摘要：Meta- analyses have concluded that positive emotions do not reduce appetitive risk behaviors (risky behaviors that fulfill appetitive or craving states, such as smoking and excessive alcohol use). We propose that this conclusion is premature. Drawing on the Appraisal Tendency Framework and related theories of emotion and decision- making, we hypothesized that gratitude (a positive emotion) can decrease cigarette smoking, a leading cause of premature death globally. A series of multimethod stud...
• Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior AI翻译
  作者：Yang, Heeseung; Lee, Daehan; Kim, Heekyeong; Cook, Daniel E.; Paik, Young - Ki; Andersen, Erik C.; Lee, Junho
  作者单位：Seoul National University (SNU); Northwestern University; Sungkyunkwan University (SKKU); Yonsei University; Seoul National University (SNU); Johns Hopkins University
  摘要：Phoresy is an interspecies interaction that facilitates spatial dispersal by attaching to a more mobile species. Hitchhiking species have evolved specific traits for physical contact and successful phoresy, but the regulatory mechanisms involved in such traits and their evolution are largely unexplored. The nematode Caenorhabditis elegans displays a hitchhiking behavior known as nictation during its stress- induced developmental stage. Dauer- specific nictation behavior has an important role i...
• Growing three-dimensional objects with light AI翻译
  作者：Lipkowitz, Gabriel; Saccone, Max A.; Panzer, Matthew A.; Coates, Ian A.; Hsiao, Kaiwen; Ilyn, Daniel; Kronenfeld, Jason M.; Tumbleston, John R.; Shaqfeh, Eric S. G.; DeSimone, Joseph M.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Vat photopolymerization (VP) additive manufacturing enables fabrication of complex 3D objects by using light to selectively cure a liquid resin. Developed in the 1980s, this technique initially had few practical applications due to limitations in print speed and final part material properties. In the four decades since the inception of VP, the field has matured substantially due to simultaneous advances in light delivery, interface design, and materials chemistry. Today, VP materials are used ...