28期

最新文章

• POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties AI翻译
  作者：Mellouk, Abdelkader; Jaouen, Paul; Ruel, Louis-Jacques; Le, Michel; Martini, Cyrielle; Moraes, Trevor F.; El Bakkouri, Majida; Lague, Patrick; Boisselier, Elodie; Calmettes, Charles
  作者单位：University of Quebec; Institut national de la recherche scientifique (INRS); University of Quebec; University of Quebec Montreal; Laval University; Laval University Hospital; Laval University; Laval University; University of Toronto; National Research Council Canada
  摘要：The outer membrane (OM) of gram- negative bacteria serves as a vital organelle that is densely populated with OM proteins (OMPs) and plays pivotal roles in cellular functions and virulence. The assembly and insertion of these OMPs into the OM represent a fundamental process requiring specialized molecular chaperones. One example is the translocation and assembly module (TAM), which functions as a transenvelope chaperone promoting the folding of specific autotransporters, adhesins, and secretio...
• Principal role of fungi in soil carbon stabilization during early pedogenesis in the high Arctic AI翻译
  作者：Trejos-Espeleta, Juan Carlos; Marin-Jaramillo, Juan P.; Schmidt, Steven K.; Sommers, Pacifica; Bradley, James A.; Orsi, William D.
  作者单位：University of Munich; University of Colorado System; University of Colorado Boulder; Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); University of London; Queen Mary University London; University of Munich; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Climate warming is causing widespread deglaciation and pioneer soil formation over glacial deposits. Melting glaciers expose rocky terrain and glacial till sediment that is relatively low in biomass, oligotrophic, and depleted in nutrients. Following initial colonization by microorganisms, glacial till sediments accumulate organic carbon and nutrients over time. However, the mechanisms driving soil nutrient stabilization during early pedogenesis after glacial retreat remain unclear. Here, we t...
• Flexible liquid- diode microtubes from multimodal microfluidics AI翻译
  作者：Yang, Chaoyu; Li, Wenzhao; Zhao, Yuanjin; Shang, Luoran
  作者单位：Southeast University - China; Nanjing University; Oujiang Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese University of Hong Kong; Fudan University
  摘要：Directional transport of liquids is of great importance in energy saving, chemical/biomedical engineering, and microfluidics applications. Despite considerable progress in engineering different open surfaces to achieve liquid manipulation, the realization of diode- like liquid transport in enclosed spaces is still challenging. Here, a flexible diode microtube is presented for directional liquid transport within confined spaces using pulsed microfluidics. The microtubes exhibit sophisticated mi...
• Molecular analysis of a self- organizing signaling pathway for Xenopus axial patterning from egg to tailbud AI翻译
  作者：Azbazdar, Yagmur; De Robertis, Edward M.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Xenopus embryos provide a favorable material to dissect the sequential steps that lead to dorsal-ventral (D- V) and anterior-posterior (A- P) cell differentiation. Here, we analyze the signaling pathways involved in this process using loss- of- function and gain- of- function approaches. The initial step was provided by Hwa, a transmembrane protein that robustly activates early beta- catenin signaling when microinjected into the ventral side of the embryo leading to complete twinned axes. The ...
• Reciprocal interactions between neuropeptide F and RYamide regulate host attraction in the mosquito Aedes aegypti AI翻译
  作者：Dou, Xiaoyi; Chen, Kangkang; Brown, Mark R.; Strand, Michael R.
  作者单位：University System of Georgia; University of Georgia
  摘要：Female mosquitoes produce eggs in gonadotrophic cycles that are divided between a previtellogenic and vitellogenic phase. Previtellogenic females consume water and sugar sources like nectar while also being attracted to hosts for blood feeding. Consumption of a blood meal activates the vitellogenic phase, which produces mature eggs and suppresses host attraction. In this study, we tested the hypothesis that neuropeptide Y- like hormones differentially modulate host attraction behavior in the m...
• MHC class I chain- related protein A antibodies and shedding are associated with the progression of multiple myeloma (vol 105, pg 1285, 2008) AI翻译
  作者：Jinushi, Masahisa; Vanneman, Matthew; Munshi, Nikhil C.; Tai, Yu- Tzu; Prabhala, Rao H.; Ritz, Jerome; Neuberg, Donna; Anderson, Kenneth C.; Carrasco, Daniel Ruben; Dranoff, Glenn
• Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models AI翻译
  作者：Lara-Saez, Irene; Mencia, Angeles; Recuero, Enrique; Li, Yinghao; Garcia, Marta; Oteo, Marta; Gallego, Marta I.; Enguita, Ana Belen; de Prado-Verdun, Diana; Sigen, A.; Wang, Wenxin; Garcia-Escuderob, Ramon; Murillas, Rodolfo; Santos, Mirentxu
  作者单位：University College Dublin; Centro de Investigaciones Energeticas, Medioambientales Tecnologicas; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Fundacion Jimenez Diaz; Universidad Carlos III de Madrid; Centro de Investigaciones Energeticas, Medioambientales Tecnologicas; Instituto de Salud Carlos III; Hospital Universitario 12 de Octubre; Anhui University of Science & Technology; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC
  摘要：Functional analysis in mouse models is necessary to establish the involvement of a set of genetic variations in tumor development. A modeling platform to facilitate and cost- effectively analyze the role of multiple genes in carcinogenesis would be valuable. Here, we present an innovative strategy for lung mutagenesis using CRISPR/Cas9 ribonucleoproteins delivered via cationic polymers. This approach allows the simultaneous inactivation of multiple genes. We validate the effectiveness of this ...
• Wnt/Wingless signaling promotes lipid mobilization through signal- induced transcriptional repression AI翻译
  作者：Liu, Mengmeng; Waduge, Rajitha-Udakara-Sampath Hemba-; Li, Xiao; Huang, Xiahe; Liu, Tzu- Hao; Han, Xianlin; Wang, Yingchun; Ji, Jun- Yuan
  作者单位：Tulane University; Princeton University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; University of Texas System; University of Texas at San Antonio
  摘要：The Wnt/Wingless signaling pathway plays critical roles in metazoan development and energy metabolism, but its role in regulating lipid homeostasis remains not fully understood. Here, we report that the activation of canonical Wnt/Wg signaling promotes lipolysis while concurrently inhibiting lipogenesis and fatty acid (3- oxidation in both larval and adult adipocytes, as well as cultured S2R+ cells, in Drosophila . Using RNA- sequencing and CUT&RUN (Cleavage Under Targets & Release Using Nucle...
• Collaborative consortia can boost postdoctoral workforce development AI翻译
  作者：Lowman, Heili E.; Desiervo, Melissa; Hall Jr, Robert O.; Jahner, Joshua P.; Jimoh, Saheed O.; Laughlin, Daniel C.; Patterson, Amy C.; Weiss-Lehman, Christopher; Barbosa, Carolina C.; Bell, Katherine L.; Blaszczak, Joanna R.; Buerkle, C. Alex; Carter, Alice M.; Collins, Sarah M.; Deleo, Victoria; Dunkle, Matt; Gannon, Dustin; Grames, Eliza M.; Harrison, Joshua G.; McFarlane, S. Eryn; Oleksy, Isabella; Powers, Breanna F.; Ray, Courtenay; Stears, Alice; Summers, Betsy; Torrens, Christa L.; Trentman, Matt; Werner, Chhaya M.; Shoemaker, Lauren G.
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Wyoming; Union College; University of Montana System; University of Montana; University of Wyoming; Colorado State University System; Colorado State University Fort Collins; Nevada System of Higher Education (NSHE); University of Nevada Reno; Oregon State University; State University of New York (SUNY) System; Binghamton University, SUNY; York University - Canada; University of Colorado System; University of Colorado Boulder; Northern Arizona University; Northern Arizona University; University of Montana System; University of Montana
• Single- cell analysis of treatment- resistant prostate cancer: Implications of cell state changes for cell surface antigen- targeted therapies AI翻译
  作者：Zaidi, Samir; Park, Jooyoung; Chan, Joseph M.; Roudier, Martine P.; Zhao, Jimmy L.; Gopalan, Anuradha; Wadosky, Kristine M.; Patel, Radhika A.; Sayar, Erolcan; Karthaus, Wouter R.; Kates, D. Henry; Chaudhary, Ojasvi; Xu, Tianhao; Masilionis, Ignas; Mazutis, Linas; Chaligne, Ronan; Obradovic, Aleksandar; Linkov, Irina; Barlas, Afsar; Jungbluth, Achim A.; Rekhtman, Natasha; Silber, Joachim; Manova-Todorova, Katia; Watson, Philip A.; True, Lawrence D.; Morrissey, Colm; Scher, Howard I.; Rathkopf, Dana E.; Morris, Michael J.; Goodrich, David W.; Choi, Jungmin; Nelson, Peter S.; Haffner, Michael C.; Sawyers, Charles L.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Korea University; Korea University Medicine (KU Medicine); Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; Memorial Sloan Kettering Cancer Center; Roswell Park Comprehensive Cancer Center; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Institute Experimental Cancer Research; NewYork-Presbyterian Hospital; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; Yale University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute
  摘要：Targeting cell surface molecules using radioligand and antibody- based therapies has yielded considerable success across cancers. However, it remains unclear how the expression of putative lineage markers, particularly cell surface molecules, varies in the process of lineage plasticity, wherein tumor cells alter their identity and acquire new oncogenic properties. A notable example of lineage plasticity is the transformation of prostate adenocarcinoma (PRAD) to neuroendocrine prostate cancer (...