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作者：Panwar, Akanksha; Rentsendorj, Altan; Jhun, Michelle; Cohen, Robert M.; Cordner, Ryan; Gull, Nicole; Pechnick, Robert N.; Duvall, Gretchen; Mardiros, Armen; Golchian, David; Schubloom, Hannah; Jin, Lee - Way; Van Dam, Debby; Vermeiren, Yannick; De Reu, Hans; Deyn, Peter Paul De; Raskatov, Jevgenij A.; Black, Keith L.; Irvin, Dwain K.; Williams, Brian A.; Wheeler, Christopher J.
作者单位：Cedars Sinai Medical Center; Emory University; Emory University; Cedars Sinai Medical Center; Western University of Health Sciences; University of California System; University of California Davis; University of Antwerp; University of Groningen; University of Groningen; University of Groningen; University of Antwerp; Wageningen University & Research; University of Antwerp; University of California System; University of California Santa Cruz; California Institute of Technology; Brigham Young University
摘要：Cerebral (Af3) f3 ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer's disease (AD), yet are insufficient to confer complete AD- like neurodegeneration experimentally. Factors acting upstream of Af3/pTau f3 /pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neurodegeneration downstream of tangle deposition in hereditary neu...
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作者：Vanoni, Carlo; Altshuler, Boris; Kravtsovd, Vladimir E.; Scardicchiob, Antonello
作者单位：International School for Advanced Studies (SISSA); Istituto Nazionale di Fisica Nucleare (INFN); Columbia University; Abdus Salam International Centre for Theoretical Physics (ICTP)
摘要：We present a renormalization group (RG) analysis of the problem of Anderson localization on a random regular graph (RRG) which generalizes the RG of Abrahams, Anderson, Licciardello, and Ramakrishnan to infinite-dimensional graphs. The RG equations necessarily involve two parameters (one being the changing connectivity of subtrees), but we show that the one-parameter scaling hypothesis is recovered for sufficiently large system sizes for both eigenstates and spectrum observables. We also expla...
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作者：Lin, Wei; Szaboa, Claudia; Liu, Tao; Tao, Huangheng; Wu, Xianfang; Wu, Jianjun
作者单位：Cleveland Clinic Foundation; Cleveland Clinic Foundation
摘要：The Type- I interferon (IFN-I)- I) response is the major outcome of stimulator of interferon genes (STING) activation in innate cells. STING is more abundantly expressed in adaptive T cells; nevertheless, its intrinsic function in T cells remains unclear. Intriguingly, we previously demonstrated that STING activation in T cells activates widespread IFN-- independent activities, which stands in contrast to the well- known STING-- mediated IFN response. Here, we have identified that STING activa...
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作者：Ma, Qianqian; Han, Xiao; Zhu, Kexin; He, Danxia; Ng, Cai Xin; Miao, Yansong
作者单位：Nanyang Technological University; Nanyang Technological University
摘要：The dynamic organization of the actin cytoskeleton, crucial for numerous cellular processes, is intricately regulated by the nucleotide state of actin filaments (F-actin). Visualization tools for specifically detecting ADP-bound F-actin, however, remain limited. Here, we introduce ADPact, a 20-amino-acid peptide that selectively binds to ADP-F-actin. ADPact allows for the precise visualization of ADP-F-actin structures both in vitro and in eukaryotic cells, particularly under energy stress con...
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作者：Alonso-Matilla, Roberto; Lam, Alice R.; Miettinen, Teemu P.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Massachusetts Institute of Technology (MIT)
摘要：Cytokinesis is the process where the mother cell's cytoplasm separates into daughter cells. This is driven by an actomyosin contractile ring that produces cortical contractility and drives cleavage furrow ingression, resulting in the formation of a thin intercellular bridge. While cytoskeletal reorganization during cytokinesis has been extensively studied, less is known about the spatiotemporal dynamics of the plasma membrane. Here, we image and model plasma membrane lipid and protein dynamics...
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作者：Henke, Martin T.; Miesse, Tyler; de Lima, Andre de Souza; Ferreira, Celso; Ravens, Thomas; Pundt, Ralph
作者单位：George Mason University; University of Alaska System; University of Alaska Anchorage
摘要：The ongoing and projected retreat of Arctic sea ice has garnered international interest toward the utilization of Arctic maritime corridors for shipping, tourism, and development. Yet, with potential for increasing traffic in Arctic regions, it's important to consider additional environmental variables affected by climate change which may threaten wave simulations and investigate the future magnitude and seasonality of sea ice risk coupled with wave hazards. Analyzing the potential 5 mo shippi...
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作者：Bard, Jonathan E.; Tylec, Brianna L.; Dubey, Ashutosh P.; Lamb, Natalie A.; Yergeau, Donald A.; Read, Laurie K.
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA
摘要：The kinetoplastid parasite, Trypanosoma brucei, , undergoes a complex life cycle entailing slender and stumpy bloodstream forms in mammals and procyclic and metacyclic forms (MFs) in tsetse fly hosts. The numerous gene regulatory events that underlie T. brucei differentiation between hosts, as well as between active and quiescent stages within each host, take place in the near absence of transcriptional control. Rather, differentiation is controlled by RNA-- binding proteins (RBPs) that associ...
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作者：Li, Jiayun; Moresco, Philip; Fearon, Douglas T.
作者单位：Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; Cornell University; Weill Cornell Medicine
摘要：Pancreatic ductal adenocarcinoma (PDA) is a potentially lethal disease lacking effective treatments. Its immunosuppressive tumor microenvironment (TME) allows it to evade host immunosurveillance and limits response to immunotherapy. Here, using the mouse KRT19-- deficient (sgKRT19-- edited) PDA model, we find that intratumoral accumulation of natural killer T (NKT) cells is required to establish an immunologically active TME. Mechanistically, intratumoral NKT cells facilitate type I interferon...
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作者：Springer, Mark S.; Gatesy, John
作者单位：University of California System; University of California Riverside; American Museum of Natural History (AMNH)
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作者：He, Axin; Wan, Liqi; Zhang, Yuchao; Yan, Zhenzhen; Guo, Pei; Han, Da; Tan, Weihong
作者单位：Shanghai Jiao Tong University; Zhejiang Cancer Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
摘要：DNA aptamers have emerged as novel molecular tools in disease theranostics owing to their high binding affinity and specificity for protein targets, which rely on their ability to fold into distinctive three-- dimensional (3D) structures. However, delicate atomic interactions that shape the 3D structures are often ignored when designing and modeling aptamers, leading to inefficient functional optimization. Challenges persist in determining high-- resolution aptamer-protein complex structures. ...
