29期

最新文章

• Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody- producing cells in different tissues AI翻译
  作者：Eslami, Mahya; Schuepbach-Mallepell, Sonia; Diana, Daniela; Willen, Laure; Kowalczyk-Quintas, Christine; Desponds, Chantal; Peter, Benjamin; Vigolo, Michele; Renevey, Francois; Donze, Olivier; Luther, Sanjiv A.; Yalkinoglu, Oezkan; Alouche, Nagham; Schneider, Pascal
  作者单位：University of Lausanne
  摘要：Antibody-- producing plasma cells fuel humoral immune responses. They also contribute to autoimmune diseases such as systemic lupus erythematosus or IgA nephropathy. Interleukin-6- 6 and the tumor necrosis factor (TNF) family ligands BAFF (B cell-- activating factor) and APRIL (a proliferation-- inducing ligand) participate in plasma cell survival. BAFF binds to three receptors, BAFFR (BAFF receptor), TACI (transmembrane activator and CAML interactor), and BCMA (B cell maturation antigen), whi...
• Reply to De Freitas: Social media language explains less of the variance in depression of Black individuals than of White individuals AI翻译
  作者：Rai, Sunny; Stade, Elizabeth C.; Giorgi, Salvatore; Francisco, Ashley; Ungar, Lyle H.; Curtis, Brenda; Guntuku, Sharath C.
  作者单位：University of Pennsylvania; University of Pennsylvania; Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); NIH National Institute on Drug Abuse (NIDA)
• Reply to Springer and Gatesy: The impact of long branches and misalignments on phylogenetic analysis is minimal AI翻译
  作者：Wu, Shaoyuan; Rheindt, Frank E.; Zhang, Jin; Wang, Jiajia; Zhang, Lei; Quan, Cheng; Li, Zhiheng; Wang, Min; Wu, Feixiang; Qu, Yanhua; Edwards, Scott, V; Zhou, Zhonghe; Liu, Liang
  作者单位：Jiangsu Normal University; National University of Singapore; Changsha University of Science & Technology; Chang'an University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Harvard University; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
• Organic nanoparticles with tunable size and rigidity by hyperbranching and cross- linking using microemulsion ATRP AI翻译
  作者：Yin, Rongguan; Tarnsangpradit, Jirameth; Gul, Akhtar; Jeong, Jaepil; Hu, Xiaolei; Zhao, Yuqi; Wu, Hanshu; Li, Qiqi; Fytas, George; Karim, Alamgir; Bockstaller, Michael R.; Matyjaszewski, Krzysztof
  作者单位：Carnegie Mellon University; Carnegie Mellon University; University of Houston System; University of Houston; Max Planck Society
  摘要：Unlike inorganic nanoparticles, organic nanoparticles (oNPs) offer the advantage of interior tailorability, thereby enabling the controlled variation of physicochemical characteristics and functionalities, for example, by incorporation of diverse functional small molecules. In this study, a unique inimer-based microemulsion approach is presented to realize oNPs with enhanced control of chemical and mechanical properties by deliberate variation of the degree of hyperbranching or cross-linking. ...
• Harnessing elastic instabilities for enhanced mixing and reaction kinetics in porous media AI翻译
  作者：Browne, Christopher A.; Datta, Sujit S.
  作者单位：Princeton University
  摘要：Turbulent flows have been used for millennia to mix solutes; a familiar example is stirring cream into coffee. However, many energy, environmental, and industrial processes rely on the mixing of solutes in porous media where confinement suppresses inertial turbulence. As a result, mixing is drastically hindered, requiring fluid to permeate long distances for appreciable mixing and introducing additional steps to drive mixing that can be expensive and environmentally harmful. Here, we demonstra...
• The West Nile virus genome harbors essential riboregulatory elements with conserved and host- specific functional roles AI翻译
  作者：Huston, Nicholas C.; Tsao, Lucille H.; Brackney, Doug E.; Pyle, Anna Marie
  作者单位：Yale University; Yale University; Connecticut Agricultural Experiment Station; Yale University; Howard Hughes Medical Institute
  摘要：West Nile virus (WNV) is an arthropod- borne, positive- sense RNA virus that poses an increasing global threat due to warming climates and lack of effective therapeutics. Like other enzootic viruses, little is known about how host context affects the structure of the full-- length RNA genome. Here, we report a complete secondary structure of the entire WNV genome within infected mammalian and arthropod cell lines. Our analysis affords structural insights into multiple, conserved aspects of fla...
• A balance between innovation and biosafety AI翻译
  作者：Perlman, Stanley
  作者单位：University of Iowa
• QnAs with Spyros ArtavanisTsakonas AI翻译
  作者：Ravindran, Sandeep
• SP1 undergoes phase separation and activates RGS20 expression through super- enhancers to promote lung adenocarcinoma progression AI翻译
  作者：Shan, Liying; Wang, Wenmeng; Du, Lijuan; Li, Dangdang; Wang, Yunxuan; Xie, Yuyan; Li, Hongyan; Wang, Jiale; Shi, Zhihao; Zhou, Yang; Zhu, Daling; Sui, Guangchao; Liu, Fang
  作者单位：Harbin Medical University; Northeast Forestry University - China; Harbin Medical University
  摘要：Lung adenocarcinoma (LUAD) is the leading cause of cancer- related death worldwide, but the underlying molecular mechanisms remain largely unclear. The transcription factor (TF) specificity protein 1 (SP1) plays a crucial role in the development of various cancers, including LUAD. Recent studies have indicated that master TFs may form phase- separated macromolecular condensates to promote super- enhancer (SE) assembly and oncogene expression. In this study, we demonstrated that SP1 undergoes p...
• It matters what you see: Graphic media images of war and terror may amplify distress AI翻译
  作者：Holman, Alison; Garfin, Dana Rose; Silver, Roxane Cohen
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Los Angeles; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Media exposure to graphic images of violence has proliferated in contemporary society, particularly with the advent of social media. Extensive exposure to media coverage immediately after the 9/11 attacks and the Boston Marathon bombings (BMB) was associated with more early traumatic stress symptoms; in fact, several hours of BMB- related daily media exposure was a stronger correlate of distress than being directly exposed to the bombings themselves. Researchers have replicated these findings ...