29期

最新文章

• Insulin receptor orchestrates kidney antibacterial defenses AI翻译
  作者：Schwartz, Laura; Simoni, Aaron; Yan, Pearlly; Salamon, Kristin; Turkoglu, Altan; Martinez, Gabriela Vasquez; Zepeda-Orozco, Diana; Eichler, Tad; Wang, Xin; Spencer, John David
  作者单位：University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University
  摘要：Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct. The collecting duct is composed of intercalated cells (ICs) and principal cells (PCs). Evidence suggests that ICs contribute to UTI defenses. Here, we interrogate how IR deletion in ICs impacts antibacterial defenses against uropathogenic Escherichia coli. We also explore how IR deletion affects immune re...
• Metabolites play an underappreciated role in development AI翻译
  作者：Juliano, Celina E.
  作者单位：University of California System; University of California Davis
• A Neuroscience (Vol 121, 29, 2024) AI翻译
  作者：Veno, Morten T.; Reschke, Cristina R.; Morris, Gareth; Connolly, Niamh M. C.; Su, Junyi; Yan, Yan; Engel, Tobias; Jimenez-Mateos, Eva M.; Harder, Lea M.; Pultz, Dennis; Haunsberger, Stefan J.; Pal, Ajay; Heller, Janosch P.; Campbell, Aoife; Langa, Elena; Brennan, Gary P.; Conboy, Karen; Richardson, Amy; Norwood, Braxton A.; Costard, Lara S.; Neubert, Valentin; Del Gallo, Federico; Salvetti, Beatrice; Vangoor, Vamshidhar R.; Sanz-Rodriguez, Amaya; Muilu, Juha; Fabene, Paolo F.; Pasterkamp, R. Jeroen; Prehn, Jochen H. M.; Schorge, Stephanie; Andersen, Jens S.; Rosenow, Felix; Bauer, Sebastian; Kjems, Jorgen; Henshall, David C.
• The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining (vol 119, e2208904119, 2022) AI翻译
  作者：Wang, Pei Lin; Teng, Liu; Feng, Yu Chen; Yue, Yi Meng; Han, Man Man; Yan, Qianqian; Ye, Kaihong; Tang, Cai Xia; Zhang, Sheng Nan; Qi, Teng Fei; Zhao, Xiao Hong; La, Ting; Zhang, Yuan Yuan; Li, Jin Ming; Hu, Bin; Xu, Dengfei; Cang, Shundong; Wang, Li; Jin, Lei; Thorne, Rick F.; Zhang, Yuwei; Liu, Tao; Zhang, Xu Dong
• An RNA aptamer exploits exosite- dependent allostery to achieve specific inhibition of coagulation factor IXa AI翻译
  作者：Kolyadko, Vladimir N.; Layzer, Juliana M.; Perry, Kay; Sullenger, Bruce A.; Krishnaswamy, Sriram
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Duke University; United States Department of Energy (DOE); Argonne National Laboratory; Cornell University; University of Pennsylvania
  摘要：Hemostasis relies on a reaction network of serine proteases and their cofactors to form a blood clot. Coagulation factor IXa (protease) plays an essential role in hemostasis as evident from the bleeding disease associated with its absence. RNA aptamers specifically targeting individual coagulation factors have potential as anticoagulants and as probes of the relationship between structure and function. Here, we report X- ray structures of human factor IXa without a ligand bound to the active s...
• Showcasing advances and building community in modeling for sustainability AI翻译
  作者：Selin, Noelle E.; Giang, Amanda; Clark, William C.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of British Columbia; University of British Columbia; Harvard University
• The dynamic behavior of chromatophores marks the transition from bands to spots in leopard geckos AI翻译
  作者：Ullate-Agote, Asier; Tzika, Athanasia C.
  作者单位：University of Geneva; University of Navarra
  摘要：Reptilian skin coloration is spectacular and diverse, yet little is known about the ontogenetic processes that govern its establishment and the molecular signaling pathways that determine it. Here, we focus on the development of the banded pattern of leopard gecko hatchlings and the transition to black spots in the adult. With our histological analyses, we show that iridophores are present in the white and yellow bands of the hatchling and they gradually perish in the adult skin. Furthermore, ...
• Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2 AI翻译
  作者：Ying, Jiafu; Yang, Yinghong; Zhang, Xuanpu; Dong, Ze; Chen, Baoen
  作者单位：Zhejiang University; Zhejiang University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University; Zhejiang University
  摘要：Defects in planar cell polarity (PCP) have been implicated in diverse human pathologies. Vangl2 is one of the core PCP components crucial for PCP signaling. Dysregulation ofVangl2 has been associated with severe neural tube defects and cancers. However, how Vangl2 protein is regulated at the posttranslational level has not been well understood. Using chemical reporters of fatty acylation and biochemical validation, here we present that Vangl2 subcellular localization is regulated by a reversib...
• Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA AI翻译
  作者：Karliner, Jordyn; Liu, Yuhong; Merry, Diane E.
  作者单位：Thomas Jefferson University
  摘要：Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease caused by a polyglutamine (polyQ)-- encoding CAG trinucleotide repeat expansion in the androgen receptor (AR) gene, leading to AR aggregation, lower motor neuron death, and muscle atrophy. AR is a ligand-- activated transcription factor that regulates neuronal architecture and promotes axon regeneration; however, whether AR transcriptional functions contribute to disease pathogenesis is not fully understood...
• Mechanical stress during confined migration causes aberrant mitoses and c-MYC amplification AI翻译
  作者：Bastianello, Giulia; Kidiyoor, Gururaj Rao; Lowndes, Conor; Li, Qingsen; Bonnal, Raoul; Godwin, Jeffrey; Iannelli, Fabio; Drufuca, Lorenzo; Bason, Ramona; Orsenigo, Fabrizio; Parazzoli, Dario; Pavani, Mattia; Cancila, Valeria; Piccolo, Stefano; Scita, Giorgio; Ciliberto, Andrea; Tripodo, Claudio; Pagani, Massimiliano; Foiani, Marco
  作者单位：IFOM - FIRC Institute of Molecular Oncology; University of Milan; University of Palermo; University of Padua; Consiglio Nazionale delle Ricerche (CNR); Istituto di Genetica Molecolare (IGM-CNR); National University of Singapore
  摘要：Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-- transduction pathways. We investigated whether the mechanical stress generated by metastatic interstitial migration contributes to the enhanced chromosomal instability observed in metastatic tumor cells. We employed live cell imaging, micro-- fluidic approaches, and scRNA-seq- seq to follow the fate of tumor cells experiencing confined migration. We found that, despite functional ATR, ATM, and spindle asse...