32期

最新文章

• Evolution of superconductivity in twisted graphene multilayers AI翻译
  作者：Long, Min; Jimeno-Pozo, Alejandro; Sainz-Cruz, Hector; Pantaleon, Pierre A.; Guinea, Francisco
  摘要：The group of moir & eacute; graphene superconductors keeps growing, and by now it contains twisted graphene multilayers as well as untwisted stacks. We analyze here the contribution of long-range charge fluctuations in the superconductivity of twisted double bilayers and helical trilayers, and compare the results to twisted bilayer graphene. A diagrammatic approach which depends on a few, well-known parameters is used. We find that the critical temperature and the order parameter differ signif...
• Evidence of ferroelectric features in low-density supercooled water from ab initio deep neural-network simulations AI翻译
  作者：Malosso, Cesare; Manko, Natalia; Izzo, Maria Grazia; Baroni, Stefano; Hassanali, Ali
  作者单位：International School for Advanced Studies (SISSA); Abdus Salam International Centre for Theoretical Physics (ICTP)
  摘要：Over the last decade, an increasing body of evidence has emerged, supporting the existence of a metastable liquid-liquid critical point in supercooled water whereby two distinct liquid phases of different densities coexist. Analyzing long molecular dynamics simulations performed using deep neural-network force fields trained to accurate quantum mechanical data, we demonstrate that the low-density liquid phase displays a strong propensity toward spontaneous polarization, as witnessed by large a...
• Antigenic cartography using variant- specific hamster sera reveals substantial antigenic variation among Omicron subvariants AI翻译
  作者：Muehlemann, Barbara; Trimpert, Jakob; Walper, Felix; Schmidt, Marie L.; Jansen, Jenny; Schroeder, Simon; Jeworowski, Lara M.; Beheim-Schwarzbach, Jorn; Bleicker, Tobias; Niemeyer, Daniela; Richter, Anja; Adler, Julia M.; Vidal, Ricardo Martin; Langner, Christine; Vladimirova, Daria; Wilks, Samuel H.; Smith, Derek J.; Voss, Mathias; Paltzow, Lea; Christophersen, Christina Martinez; Rose, Ruben; Krumbholz, Andi; Jones, Terry C.; Corman, Victor M.; Drosten, Christian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; German Center for Infection Research; Free University of Berlin; University of Cambridge; University of Kiel; University of Kiel; Schleswig Holstein University Hospital; Labor Berlin - Charite Vivantes GmbH
  摘要：Severe acute respiratory syndrome Coronavirus 2 (SARS-- CoV-2)- 2) has developed substantial antigenic variability. As the majority of the population now has pre-- existing immunity due to infection or vaccination, the use of experimentally generated animal immune sera can be valuable for measuring antigenic differences between virus variants. Here, we immunized Syrian hamsters by two successive infections with one of nine SARS-CoV-2- CoV- 2 variants. Their sera were titrated against 16 SARS-C...
• An arginine- rich nuclear localization signal (ArgiNLS) strategy for streamlined image segmentation of single cells AI翻译
  作者：Szelenyi, Eric R.; Navarrete, Jovana S.; Murry, Alexandria D.; Zhang, Yizhe; Girven, Kasey S.; Kuo, Lauren; Cline, Marcella M.; Bernstein, Mollie X.; Burdyniuk, Mariia; Bowler, Bryce; Goodwin, Nastacia L.; Juarez, Barbara; Zweifel, Larry S.; Golden, Sam A.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University System of Maryland; University of Maryland Baltimore
  摘要：High- throughput volumetric fluorescent microscopy pipelines can spatially integrate whole- brain structure and function at the foundational level of single cells. However, conventional fluorescent protein (FP) modifications used to discriminate single cells possess limited efficacy or are detrimental to cellular health. Here, we introduce a synthetic and nondeleterious nuclear localization signal (NLS) tag strategy, called Arginine-rich NLS (ArgiNLS), that optimizes genetic labeling and downs...
• Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: A target for antifungals AI翻译
  作者：Zhou, Ye; Washington, Erica J.; Hsu, Allen L.; Petrovich, Matthew; Tenor, Jennifer L.; Toffaletti, Dena L.; Guan, Ziqiang; Perfect, John R.; Borgnia, Mario J.; Bartesaghi, Alberto; Brennan, Richard G.
  作者单位：Duke University; Duke University; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Duke University
  摘要：Invasive fungal diseases are a major threat to human health, resulting in more than 1.5 million annual deaths worldwide. The arsenal of antifungal therapeutics remains limited and is in dire need of drugs that target additional biosynthetic pathways that are absent from humans. One such pathway involves the biosynthesis of trehalose. Trehalose is a disaccharide that is required for pathogenic fungi to survive in their human hosts. In the first step of trehalose biosynthesis, trehalose-6- phosp...
• Nutrient and moisture limitations reveal keystone metabolites linking rhizosphere metabolomes and microbiomes AI翻译
  作者：Baker, Nameer R.; Zhalnina, Kateryna; Yuan, Mengting; Herman, Don; Ceja-Navarro, Javier A.; Sasse, Joelle; Jordan, Jacob S.; Bowen, Benjamin P.; Wu, Liyou; Fossum, Christina; Chew, Aaron; Fu, Ying; Saha, Malay; Zhou, Jizhong; Pett-Ridge, Jennifer; Northen, Trent R.; Firestone, Mary K.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Northern Arizona University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Zurich; University of California System; University of California Berkeley; University of Oklahoma System; University of Oklahoma - Norman; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Noble Research Institute; University of California System; University of California Merced
  摘要：Plants release a wealth of metabolites into the rhizosphere that can shape the composition and activity of microbial communities in response to environmental stress. The connection between rhizodeposition and rhizosphere microbiome succession has been suggested, particularly under environmental stress conditions, yet definitive evidence is scarce. In this study, we investigated the relationship between rhizosphere chemistry, microbiome dynamics, and abiotic stress in the bioenergy crop switchg...
• Climate change and public health in California: A structured review of exposures, vulnerable populations, and adaptation measures AI翻译
  作者：Jerrett, Michael; Connolly, Rachel; Garcia-Gonzales, Diane A.; Bekker, Claire; Nguyen, Jenny T.; Su, Jason; Li, Yang; Marlier, Miriam E.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Berkeley; Baylor University
  摘要：California faces several serious direct and indirect climate exposures that can adversely affect public health, some of which are already occurring. The public health burden now and in the future will depend on atmospheric greenhouse gas concentrations, underlying population vulnerabilities, and adaptation efforts. Here, we present a structured review of recent literature to examine the leading climate risks to public health in California, including extreme heat, extreme precipitation, wildfir...
• Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post- transcriptional compensation AI翻译
  作者：Lister, Nicholas C.; Milton, Ashley M.; Patel, Hardip R.; Waters, Shafagh A.; Hanrahan, Benjamin J.; McIntyre, Kim L.; Livernois, Alexandra M.; Horspool, William B.; Wee, Lee Kian; Ringel, Alessa R.; Mundlos, Stefan; Robson, Michael I.; Shearwin-Whyatt, Linda; Grutzner, Frank; Graves, Jennifer A. Marshall; Ruiz-Herrera, Aurora; Waters, Paul D.
  作者单位：University of New South Wales Sydney; Australian National University; John Curtin School of Medical Research; Australian National University; University of New South Wales Sydney; Max Planck Society; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Edinburgh; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Adelaide; La Trobe University; University of Canberra; Autonomous University of Barcelona; Autonomous University of Barcelona
  摘要：Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced tr...
• Lithium isotopic evidence for enhanced reverse weathering during the Early Triassic warm period AI翻译
  作者：Rauzi, Sofia; Foster, William J.; Takahashi, Satoshi; Hori, Rie S.; Beaty, Brian J.; Tarhan, Lidya G.; Isson, Terry
  作者单位：University of Waikato; University of Hamburg; Nagoya University; Ehime University; Yale University
  摘要：Elevated temperatures persisted for an anomalously protracted interval following pulsed volcanic carbon release associated with the end- Permian mass extinction, deviating from the expected timescale of climate recovery following a carbon injection event. Here, we present evidence for enhanced reverse weathering-a CO2 source-following the end- Permian mass extinction based on the lithium isotopic composition of marine shales and cherts. We find that the average lithium isotopic composition of ...
• Mimicking lightning-induced electrochemistry on the early Earth AI翻译
  作者：Jiang, Haihui Joy; Underwood, Thomas C.; Bell, Jeffrey G.; Lei, Jonathan; Gonzales, Joe C.; Emge, Lukas; Tadese, Leah G.; Rahman, Mohamed K. Abd El-; Wilmouth, David M.; Brazaca, Lais C.; Ni, Gigi; Belding, Lee; Dey, Supriya; Ashkarran, Ali Akbar; Nagarkar, Amit; Nemitz, Markus P.; Cafferty, Brian J.; Sayres, David S.; Ranjan, Sukrit; Crocker, Daniel R.; Anderson, James G.; Sasselov, Dimitar D.; Whitesides, George M.
  作者单位：Harvard University; Harvard University; University of Texas System; University of Texas Austin; Harvard University; University of Arizona; University of Arizona; Harvard University
  摘要：To test the hypothesis that an abiotic Earth and its inert atmosphere could form chemically reactive carbon- and nitrogen- containing compounds, we designed a plasma electrochemical setup to mimic lightning- induced electrochemistry under steady- state conditions of the early Earth. Air- gap electrochemical reactions at air-water-ground interfaces lead to remarkable yields, with up to 40 moles of carbon dioxide being reduced into carbon monoxide and formic acid, and 3 moles of gaseous nitrogen...