32期

最新文章

• HaloTag as a substrate-based macroautophagy reporter AI翻译
  作者：Xiao, Qiang; Cruz, Gabrielle; Botham, Rachel; Fox, Susan G.; Yu, Anan; Allen, Seth; Morimoto, Richard I.; Kelly, Jeffery W.
  作者单位：Scripps Research Institute; Scripps Research Institute; State University of New York (SUNY) System; SUNY Fredonia; Northwestern University
  摘要：Macroautophagy is a conserved cellular degradation pathway that, upon upregulation, confers resilience toward various stress conditions, including protection against proteotoxicity associated with neurodegenerative diseases, leading to cell survival. Monitoring autophagy regulation in living cells is important to understand its role in physiology and pathology, which remains challenging. Here, we report that when HaloTag is expressed within a cell of interest and reacts with tetramethylrhodami...
• Climate change and California sustainability-Challenges and solutions AI翻译
  作者：Franklin, Janet; Macdonald, Glen M.
  作者单位：California State University System; San Diego State University; University of California System; University of California Los Angeles
• Fragment correlation mass spectrometry: Determining the structures of biopolymers in a complex mixture without isolating individual components AI翻译
  作者：Li, Yangjie; Cavet, Guy; Zare, Richard N.; Driver, Taran
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
  摘要：Fragment correlation mass spectrometry correlates ion pairs generated from the same fragmentation pathway, achieved by covariance mapping of tandem mass spectra generated with an unmodified linear ion trap without preseparation. We enable the identification of different precursors at different charge states in a complex mixture from a large isolation window, empowering an analytical approach for data- independent acquisition. The method resolves and matches isobaric fragments, internal ions, a...
• Active regulation of amyloidosis AI翻译
  作者：Lin, Yi
  作者单位：Tsinghua University
• Competing adaptations maintain nonadaptive variation in a wild cricket population AI翻译
  作者：Rayner, Jack G.; Eichenberger, Franca; Bainbridge, Jessica V. A.; Zhang, Shangzhe; Zhang, Xiao; Yusuf, Leeban H.; Balenger, Susan; Gaggiotti, Oscar E.; Bailey, Nathan W.
  作者单位：University System of Maryland; University of Maryland College Park; University of St Andrews; University of Lausanne; Tianjin Normal University; University of Minnesota System; University of Minnesota Twin Cities
  摘要：How emerging adaptive variants interact is an important factor in the evolution of wild populations, but the opportunity to empirically study this interaction is rare. We recently documented the emergence of an adaptive phenotype curly- wing in Hawaiian populations of field crickets ( Teleogryllus oceanicus). Curly- wing inhibits males' ability to sing, protecting them from eavesdropping parasitoid flies ( Ormia ochracea). Surprisingly, curly- wing co- occurs with similarly protective silent f...
• How viscous bubbles collapse: Topological and symmetry-breaking instabilities in curvature-driven hydrodynamics AI翻译
  作者：Davidovitch, Benny; Klein, Avraham
  作者单位：University of Massachusetts System; University of Massachusetts Amherst; Ariel University
  摘要：The duality between deformations of elastic bodies and noninertial flows in viscous liquids has been a guiding principle in decades of research. However, this duality is broken when a spheroidal or other doubly curved liquid film is suddenly forced out of mechanical equilibrium, as occurs, e.g., when the pressure inside a liquid bubble drops rapidly due to rupture or controlled evacuation. In such cases, the film may evolve through a noninertial yet geometrically nonlinear surface dynamics, wh...
• Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions AI翻译
  作者：Dolan, Stephen K.; Duong, Ashley T.; Whiteley, Marvin
  作者单位：University System of Georgia; Georgia Institute of Technology; Clemson University; University System of Georgia; Georgia Institute of Technology
  摘要：Microbes rarely exist in isolation and instead form complex polymicrobial communities. As a result, microbes have developed intricate offensive and defensive strategies that enhance their fitness in these complex communities. Thus, identifying and understanding the molecular mechanisms controlling polymicrobial interactions is critical for understanding the function of microbial communities. In this study, we show that the gram- negative opportunistic human pathogen Pseudomonas aeruginosa, whi...
• Indigenous food production in a carbon economy AI翻译
  作者：Ready, Elspeth; Ross, Cody T.; Beheim, Bret; Parrott, Jenn
  作者单位：Max Planck Society; State University System of Florida; University of Florida
  摘要：Indigenous communities in the North American Arctic are characterized by mixed economies that feature hunting, fishing, gathering, and trapping activities-and associated sharing practices-alongside the formal wage economy. The region is also undergoing rapid social, economic, and climate changes, including, in Canada, carbon taxation, which is impacting the cost of fuel used in local food harvesting. Because of the importance of local foods to nutrition, health, and well- being in Arctic Indig...