32期

最新文章

• Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels AI翻译
  作者：Zaki, Afroditi-Mario; Cinaroglu, Sueleyman Selim; Rahman, Taufiq; Patel, Sandip; Biggin, Philip C.
  作者单位：University of Oxford; University of Cambridge; University of London; University College London; Ege University
  摘要：Two- pore channels are pathophysiologically important Na+- and Ca2+- permeable channels expressed in lysosomes and other acidic organelles. Unlike most other ion channels, their permeability is malleable and ligand- tuned such that when gated by the signaling lipid PI(3,5)P2, they are more Na+- selective than when gated by the Ca2+ mobilizing messenger nicotinic acid adenine dinucleotide phosphate. However, the structural basis that underlies such plasticity and single- channel behavior more g...
• Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease AI翻译
  作者：Khan, Shahzad S.; Jaimon, Ebsy; Lin, Yu-En; Nikoloff, Jonas; Tonelli, Francesca; Alessi, Dario R.; Pfeffer, Suzanne R.
  作者单位：Stanford University; University of Dundee; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Activating leucine-rich repeat kinase 2 (LRRK2) mutations cause Parkinson's and phosphorylation of Rab10 by pathogenic LRRK2 blocks primary ciliogenesis in cultured cells. In the mouse brain, LRRK2 blockade of primary cilia is highly cell type specific: For example, cholinergic interneurons and astrocytes but not medium spiny neurons of the dorsal striatum lose primary cilia in LRRK2- pathway mutant mice. We show here that the cell type specificity of LRRK2- mediated cilia loss is also seen in...
• California dreaming: Why environmental justice is integral to the success of climate change policy AI翻译
  作者：Pastor, Manuel; Cha, J. Mijin; Mendez, Michael; Morello-Frosch, Rachel
  作者单位：University of Southern California; University of California System; University of California Santa Cruz; University of California System; University of California Irvine; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：In the realm of climate policy, issues of environmental justice (EJ) are often treated as second- order affairs compared to overarching sustainability goals. We argue that EJ is in fact critical to successfully addressing our national and global climate challenges; indeed, centering equity amplifies the voices of the diverse constituencies most impacted by climate change and that are needed to build successful coalitions that shape and advance climate change policy. We illustrate this perspect...
• Reply to Stromland et al.: Confusion should be minimized rather than used to explain cooperation in public goods game experiments AI翻译
  作者：Wang, Guangrong; Li, Jianbiao; Wang, Wenhua; Niu, Xiaofei; Wang, Yue
  作者单位：Weifang University; Shandong University; Nankai University
• A nitrogen isotopic shift in fish otolith-bound organic matter during the Late Cretaceous AI翻译
  作者：Rao, Zixuan C.; Lueders-Dumont, Jessica A.; Stringer, Gary L.; Ryu, Yeongjun; Zhao, Kewei; Myneni, Satish C.; Oleynik, Sergey; Haug, Gerald H.; Martinez-Garcia, Alfredo; Sigman, Daniel M.
  作者单位：Princeton University; Max Planck Society; Smithsonian Institution; Smithsonian Tropical Research Institute; Boston College; University of Louisiana System; University of Louisiana Monroe; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The nitrogen isotopes of the organic matter preserved in fossil fish otoliths (ear stones) are a promising tool for reconstructing past environmental changes. We analyzed the N-15/N-14 ratio (delta N-15) of fossil otolith-bound organic matter in Late Cretaceous fish otoliths (of Eutawichthys maastrichtiensis, Eutawichthys zideki and Pterothrissus sp.) from three deposits along the US east coast, with two of Campanian (83.6 to 77.9 Ma) and one Maastrichtian (72.1 to 66 Ma) age. delta N-15 and N...
• Slow convergence: Career impediments to interdisciplinary biomedical research AI翻译
  作者：Berkes, Enrico; Marion, Monica; Milojevic, Stasa; Weinberg, Bruce A.
  作者单位：University System of Maryland; University of Maryland Baltimore County; Indiana University System; Indiana University Bloomington; University System of Ohio; Ohio State University; IZA Institute Labor Economics; National Bureau of Economic Research
  摘要：Despite the long- standing calls for increased levels of interdisciplinary research as a way to address society's grand challenges, most science is still disciplinary. To understand the slow rate of convergence to more interdisciplinary research, we examine 154,021 researchers who received a PhD in a biomedical field between 1970 and 2013, measuring the interdisciplinarity of their articles using the disciplinary composition of references. We provide a range of evidence that interdisciplinary ...
• Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium-secreted proteins (vol 120, e2308676120, 2023) AI翻译
  作者：Fierro, Manuel A.; Hussain, Tahir; Campin, Liam J.; Beck, Josh R.
• Synthetic data can aid the analysis of clinical outcomes: How much can it be trusted? AI翻译
  作者：Adam, David
• The RPD3L deacetylation complex is required for facultative heterochromatin repression in Neurospora crassa AI翻译
  作者：Mumford, Colleen C.; Tanizawa, Hideki; Wiles, Elizabeth T.; McNaught, Kevin J.; Jamieson, Kirsty; Tsukamoto, Kenta; Selker, Eric U.
  作者单位：University of Oregon; Hokkaido University; University of California System; University of California Irvine; United States Department of Energy (DOE); Oak Ridge National Laboratory; Reed College - Portland
  摘要：Repression of facultative heterochromatin is essential for developmental processes in repressive complex 2 is a prominent feature of facultative heterochromatin in both fungi and higher eukaryotes. Although this methylation is frequently associated with silencing, the detailed mechanism of repression remains incompletely understood. We utilized a forward genetics approach to identify genes required to maintain silencing at facultative heterochromatin genes in Neurospora crassa and identified t...
• In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells AI翻译
  作者：Palanki, Rohan; Riley, John S.; Bose, Sourav K.; Luks, Valerie; Dave, Apeksha; Kus, Nicole; White, Brandon M.; Ricciardi, Adele S.; Swingle, Kelsey L.; Xue, Lulu; Sung, Derek; Thatte, Ajay S.; Safford, Hannah C.; Chaluvadi, Venkata S.; Carpenter, Marco; Han, Emily L.; Maganti, Rohin; Hamilton, Alex G.; Mrksich, Kaitlin; Billingsley, Margaret B.; Zoltick, Philip W.; Alameh, Mohamad- Gabriel; Weissman, Drew; Mitchell, Michael J.; Peranteau, William H.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Monogenic blood diseases are among the most common genetic disorders worldwide. These diseases result in significant pediatric and adult morbidity, and some can result in death prior to birth. Novel ex vivo hematopoietic stem cell (HSC) gene editing therapies hold tremendous promise to alter the therapeutic landscape but are not without potential limitations. In vivo gene editing therapies offer a potentially safer and more accessible treatment for these diseases but are hindered by a lack of ...