32期

最新文章

• With the leisure of time, kinetic proofreading can still perform reliable ligand discrimination AI翻译
  作者：Xiao, Fangzhou; Galstyan, Vahe
  作者单位：University of California System; University of California San Diego; AMOLF
• Confusion remains an important issue in public goods game experiments AI翻译
  作者：Stromland, Eirik; Koppel, Lina; Johannesson, Magnus; Tinghog, Gustav
  作者单位：Western Norway University of Applied Sciences; Linkoping University; Stockholm School of Economics
• Climate change and California's terrestrial biodiversity AI翻译
  作者：Harrison, Susan; Franklin, Janet; Hernandez, Rebecca R.; Ikegami, Makihiko; Safford, Hugh D.; Thorne, James H.
  作者单位：University of California System; University of California Davis; California State University System; San Diego State University; University of California System; University of California Davis; University of California System; University of California Davis; National Institute for Environmental Studies - Japan
  摘要：In this review and synthesis, we argue that California is an important test case for the nation and world because terrestrial biodiversity is very high, present and anticipated threats to biodiversity from climate change and other interacting stressors are severe, and innovative approaches to protecting biodiversity in the context of climate change are being developed and tested. We first review salient dimensions of California's terrestrial physical, biological, and human diversity. Next, we ...
• Cultivating climate resilience in California agriculture: Adaptations to an increasingly volatile water future AI翻译
  作者：Medellin-Azuara, Josue; Escriva-Bou, Alvar; Gaudin, Amelie C. M.; Schwabe, Kurt A.; Sumner, Daniel A.
  作者单位：University of California System; University of California Merced; University of California System; University of California Los Angeles; University of California System; University of California Davis; University of California System; University of California Riverside; University of California System; University of California Davis
  摘要：California agriculture will undergo significant transformations over the next few decades in response to climate extremes, environmental regulation and policy encouraging environmental justice, and economic pressures that have long driven agricultural changes. With several local climates suited to a variety of crops, periodically abundant nearby precipitation, and public investments that facilitated abundant low- priced irrigation water, California hosts one of the most diverse and productive ...
• A randomized trial of behavioral interventions yielding sustained reductions in distracted driving AI翻译
  作者：Ebert, Jeffrey P.; Xiong, Ruiying A.; Khan, Neda; Abdel-Rahman, Dina; Leitner, Aaron; Everett, William C.; Gaba, Kristen L.; Fisher, William J.; Mcdonald, Catherine C.; Winston, Flaura K.; Rosin, Roy M.; Volpp, Kevin G.; Barnett, Ian J.; Wiebe, Douglas J.; Halpern, Scott D.; Delgado, Mucio Kit
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Michigan System; University of Michigan
  摘要：Distracted driving is responsible for nearly 1 million crashes each year in the United States alone, and a major source of driver distraction is handheld phone use. We conducted a randomized, controlled trial to compare the effectiveness of interventions designed to create sustained reductions in handheld use while driving (NCT04587609). Participants were to 77 who averaged at least 2 min/h of handheld use while driving in the month prior to study invitation. They were randomly assigned to one...
• Huntingtin contains an ubiquitin- binding domain and regulates lysosomal targeting of mitochondrial and RNA- binding proteins AI翻译
  作者：Fote, Gianna M.; V. Eapen, Vinay; Lim, Ryan G.; Yu, Clinton; Salazar, Lisa; Mcclure, Nicolette R.; Mcknight, Jharrayne; Nguyen, Thai B.; Heath, Marie C.; Lau, Alice L.; Villamil, Mark A.; Miramontes, Ricardo; Kratter, Ian H.; Finkbeiner, Steven; Reidling, Jack C.; Paulo, Joao A.; Kaiser, Peter; Huang, Lan; Housman, David E.; Thompson, Leslie M.; Steffan, Joan S.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Harvard Medical School; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California San Francisco; The J David Gladstone Institutes; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Massachusetts Institute of Technology (MIT); University of California System; University of California Irvine
  摘要：Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in the HTT gene, encoding an expanded polyglutamine (polyQ) repeat within the HTT protein, causes HD and may compromise HTT's normal activity contributing to HD pathology. Here, we investigated the previously defined role of HTT in autophagy specifically through studying HTT's association with ...
• Targeting the muscarinic M1 receptor with a selective, brain- penetrant antagonist to promote remyelination in multiple sclerosis (Publication with Expression of Concern. See vol. 122, 2025) AI翻译
  作者：Poon, Michael M.; Lorrain, Kym I.; Stebbins, Karin J.; Edu, Geraldine C.; Broadhead, Alexander R.; Lorenzana, Ariana J.; Roppe, Jeffrey R.; Baccei, Jill M.; Baccei, Christopher S.; Chen, Austin C.; Green, Ari J.; Lorrain, Daniel S.; Chan, Jonah R.
  作者单位：University of California System; University of California San Francisco
  摘要：Multiple sclerosis (MS) is a chronic and debilitating neurological disease that results in inflammatory demyelination. While endogenous remyelination helps to recover function, this restorative process tends to become less efficient over time. Currently, intense efforts aimed at the mechanisms that promote remyelination are being considered promising therapeutic approaches. The M1 muscarinic acetylcholine receptor (M1R) was previously identified as a negative regulator of oligodendrocyte diffe...
• Versatile, modular, and customizable magnetic solid- droplet systems AI翻译
  作者：Sun, Mengmeng; Wu, Yingdan; Zhang, Jianhua; Zhang, Hongchuan; Liu, Zemin; Li, Mingtong; Wang, Chunxiang; Sitti, Metin
  作者单位：Max Planck Society; Harbin Institute of Technology; Koc University; Koc University
  摘要：Magnetic miniature robotic systems have attracted broad research interest because of their precise maneuverability in confined spaces and adaptability to diverse environments, holding significant promise for applications in both industrial infrastructures and biomedical fields. However, the predominant construction methodology involves the preprogramming of magnetic components into the system's structure. While this approach allows for intricate shape transformations, it exhibits limited flexi...
• An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation AI翻译
  作者：Alakhras, Nada S.; Zhang, Wenwu; Barros, Nicolas; Sharma, Anchal; Ropa, James; Priya, Raj; Yang, X. Frank; Kaplan, Mark H.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Eli Lilly
  摘要：Although many cytokine pathways are important for dendritic cell (DC) development, it is less clear what cytokine signals promote the function of mature dendritic cells. The signal transducer and activator of transcription 4 (STAT4) promotes protective immunity and autoimmunity downstream of proinflammatory cytokines including IL- 12 and IL- 23. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), Stat4-/- mice are resistant to the development of infl...
• Different mechanisms of contextual inference govern associatively learned and sensory- evoked postural responses AI翻译
  作者：Leeuwis, Matto; Asar, Yomna; White, Joshua J.; Rasman, Brandon G.; Forbes, Patrick A.
  作者单位：Erasmus University Rotterdam; Erasmus MC; Radboud University Nijmegen
  摘要：Human standing balance relies on the continuous monitoring and integration of sensory signals to infer our body's motion and orientation within the environment. However, when sensory information is no longer contextually relevant to balancing the body (e.g., when sensory and motor signals are incongruent), sensory- evoked balance responses are rapidly suppressed, much earlier than any conscious perception of changes in balance control. Here, we used a robotic balance simulator to assess whethe...