32期

最新文章

• Reply to Xiao and Galstyan: Reliable ligand discrimination involves many trade-offs AI翻译
  作者：Kirby, Duncan
  作者单位：University of Toronto
• Secondary structure determines electron transport in peptides AI翻译
  作者：Samajdar, Rajarshi; Meigooni, Moeen; Yang, Hao; Li, Jialing; Liu, Xiaolin; Jackson, Nicholas E.; Mosquera, Martin A.; Tajkhorshid, Emad; Schroeder, Charles M.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Montana State University System; Montana State University Bozeman; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Proteins play a key role in biological electron transport, but the structure-function relationships governing the electronic properties of peptides are not fully understood. Despite recent progress, understanding the link between peptide conformational flexibility, hierarchical structures, and electron transport pathways has been challenging. Here, we use single- molecule experiments, molecular dynamics (MD) simulations, nonequimachine learning to understand the role of secondary structure on ...
• The future of open research policy should be evidence based AI翻译
  作者：Sharp, Phillip A.; Bonvillian, William B.; Brand, Amy; Goldston, David; Stebbins, Michael
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Recall tempo of Hebbian sequences depends on the interplay of Hebbian kernel with tutor signal timing AI翻译
  作者：Farrell, Matthew; Pehlevan, Cengiz
  作者单位：Harvard University; Harvard University; Harvard University; RIKEN
  摘要：Understanding how neural circuits generate sequential activity is a longstanding challenge. While foundational theoretical models have shown how sequences can be stored as memories in neural networks with Hebbian plasticity rules, these models considered only a narrow range of Hebbian rules. Here, we introduce a model for arbitrary Hebbian plasticity rules, capturing the diversity of spike-timing-dependent synaptic plasticity seen in experiments, and show how the choice of these rules and of n...
• Anticipating responses to climate change and planning for resilience in California's freshwater ecosystems AI翻译
  作者：Power, Mary E.; Chandra, Sudeep; Gleick, Peter; Dietrich, William E.
  作者单位：University of California System; University of California Berkeley; Nevada System of Higher Education (NSHE); University of Nevada Reno; University of California System; University of California Berkeley
  摘要：As human- caused climate changes accelerate, California will experience hydrologic and temperature conditions different than any encountered in recorded history. How will these changes affect the state's freshwater ecosystems? Rivers, lakes, and wetlands are managed as a water resource, but they also support a complex web of life, ranging from bacteria, fungi, and algae to macrophytes, woody plants, invertebrates, fish, amphibians, reptiles, birds, and mammals. In much of the state, native fre...
• Identification and characterization of a small- molecule metallophore involved in lanthanide metabolism AI翻译
  作者：Zytnick, Alexa M.; Gutenthaler-Tietze, Sophie M.; Aron, Allegra T.; Reitz, Zachary L.; Phi, Manh Tri; Good, Nathan M.; Petras, Daniel; Daumann, Lena J.; Martinez-Gomez, Norma Cecilia
  作者单位：University of California System; University of California Berkeley; University of Munich; Heinrich Heine University Dusseldorf; University of Denver; Wageningen University & Research; University of California System; University of California Santa Barbara; Eberhard Karls University of Tubingen
  摘要：Many bacteria secrete metallophores, low- molecular- weight organic compounds that bind ions with high selectivity and affinity, in order to access essential metals from the environment. Previous work has elucidated the structures and biosynthetic machinery of metallophores specific for iron, zinc, nickel, molybdenum, and copper. No physiologically relevant lanthanide- binding metallophore has been discovered despite the knowledge that lanthanide metals (Ln) have been revealed to be essential ...
• Reconstruction of single- cell lineage trajectories and identification of diversity in fates during the epithelial- to- mesenchymal transition AI翻译
  作者：Cheng, Yu - Chen; Zhang, Yun; Tripathi, Shubham; Harshavardhan, B. V.; Jolly, Mohit Kumar; Schiebinger, Geoffrey; Levine, Herbert; Mcdonald, Thomas O.; Michor, Franziska
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Yale University; Indian Institute of Science (IISC) - Bangalore; Indian Institute of Science (IISC) - Bangalore; University of British Columbia; Northeastern University; Northeastern University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Exploring the complexity of the epithelial- to- mesenchymal transition (EMT) unveils a diversity of potential cell fates; however, the exact timing and mechanisms by which early cell states diverge into distinct EMT trajectories remain unclear. Studying these EMT trajectories through single- cell RNA sequencing is challenging due to the necessity of sacrificing cells for each measurement. In this study, we employed optimal- transport analysis to reconstruct the past trajectories of different c...
• Significant challenges to the sustainability of the California coast considering climate change AI翻译
  作者：Thorne, Karen M.; Macdonald, Glen M.; Chavez, Francisco P.; Ambrose, Richard F.; Barnard, Patrick L.
  作者单位：United States Department of the Interior; United States Geological Survey; University of California System; University of California Los Angeles; Monterey Bay Aquarium Research Institute; University of California System; University of California Los Angeles; United States Department of the Interior; United States Geological Survey
  摘要：Climate change is an existential threat to the environmental and socioeconomic sustainability of the coastal zone and impacts will be complex and widespread. Evidence from California and across the United States shows that climate change is impacting coastal communities and challenging managers with a plethora of stressors already present. Widespread action could be taken that would sustain California's coastal ecosystems and communities. In this perspective, we highlight the main threat to co...
• Propagation of distinct CWD prion strains during peripheral and intracerebral challenges of gene- targeted mice AI翻译
  作者：Defranco, Joseph P.; Bian, Jifeng; Kim, Sehun; Crowell, Jenna; Webster, Bailey K.; Atkinson, Zoe N.; Telling, Glenn C.
  作者单位：United States Department of Agriculture (USDA); USDA Agricultural Research Service; INRAE
  摘要：Since prion diseases result from infection and neurodegeneration of the central nervous system (CNS), experimental characterizations of prion strain properties customarily rely on the outcomes of intracerebral challenges. However, natural transmission of certain prions, including those causing chronic wasting disease (CWD) in elk and deer, depends on propagation in peripheral host compartments prior to CNS infection. Using gene- targeted GtE and GtQ mice, which accurately control cellular elk ...
• Precision- guided tools for malaria control AI翻译
  作者：Rasgon, Jason L.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park