32期

最新文章

• Longitudinal stability of individual brain plasticity patterns in blindness AI翻译
  作者：Amaral, Lenia; Thomas, Peyton; Amedi, Amir; Striem-Amit, Ella
  作者单位：Georgetown University; Reichman University; Reichman University
  摘要：The primary visual cortex (V1) in blindness is engaged in a wide spectrum of tasks and sensory modalities, including audition, touch, language, and memory.This widespread involvement raises questions regarding the constancy of its role and whether it might exhibit flexibility in its function over time, connecting to diverse network functions specific to task demands. This would suggest that reorganized V1 assumes a role like multiple- demand system regions. Alternatively, varying patterns of p...
• Misinformation in and about science (vol 118, e1912444117, 2021) AI翻译
  作者：West, Jevin D.; Bergstrom, Carl T.
• Heterogeneity in effect size estimates AI翻译
  作者：Holzmeister, Felix; Johannesson, Magnus; Boehm, Robert; Dreber, Anna; Huber, Juergen; Kirchler, Michael
  作者单位：University of Innsbruck; Stockholm School of Economics; University of Vienna; University of Copenhagen; University of Copenhagen; University of Innsbruck
  摘要：A typical empirical study involves choosing a sample, a research design, and an analysis path. Variation in such choices across studies leads to heterogeneity in results that introduce an additional layer of uncertainty, limiting the generalizability of published scientific findings. We provide a framework for studying heterogeneity in the social sciences and divide heterogeneity into population, design, and analytical heterogeneity. Our framework suggests that after accounting for heterogenei...
• Isotope and morphometrical evidence reveals the technological package associated with agriculture adoption in western Europe AI翻译
  作者：Araus, Jose L.; Gascon, Mireia; Ros-Sabe, Eva; Pique, Raquel; Rezzouk, Fatima Z.; Aguilera, Monica; Voltas, Jordi; Pena- Chocarro, Leonor; Perez-Jorda, Guillem; Terradas, Xavier; Palomo, Antoni; Ferrio, Juan Pedro; Antolin, Ferran
  作者单位：University of Barcelona; Autonomous University of Barcelona; Universitat de Lleida; Consejo Superior de Investigaciones Cientificas (CSIC); University of Valencia; Consejo Superior de Investigaciones Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas (CSIC); University of Basel
  摘要：This study aimed to reconstruct the environmental conditions and the crop management practices and plant characteristics when agriculture appeared in western Europe. We analyzed oak charcoal and a large number of cereal caryopsides recovered from La Peninsula. The carbon isotope discrimination (013C) values of oak, the dominant forest species in the region, indicates prevalence of a wet climate at the site. Further, we reconstructed crop management conditions, achievable yield, and crop charac...
• Unraveling clonal CD8 T cell expansion and identification of essential factors in γ- herpesvirus- induced lymphomagenesis AI翻译
  作者：Gong, Meijiao; Myster, Francoise; Azouz, Abdulkader; Sanchez, Guillem Sanchez; Li, Shifang; Charloteaux, Benoit; Yang, Bin; Nichols, Jenna; Lefevre, Lucas; Javaux, Justine; Leemans, Sylvain; Nivelles, Olivier; van Campe, Willem; Roels, Stefan; Mostin, Laurent; van den Berg, Thierry; Davison, Andrew J.; Gillet, Laurent; Connelley, Timothy; Vermijlen, David; Goriely, Stanislas; Vanderplasschen, Alain; Dewals, Benjamin G.
  作者单位：University of Liege; Universite Libre de Bruxelles; Universite Libre de Bruxelles; WELBIO; University of Liege; University of Glasgow; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; Sciensano
  摘要：Alcelaphine gammaherpesvirus 1 (AlHV- 1) asymptomatically persists in its natural host, the wildebeest. However, cross- species transmission to cattle results in the induction of an acute and lethal peripheral T cell lymphoma- like disease (PTCL), named malignant catarrhal fever (MCF). Our previous findings demonstrated an essential role for viral genome maintenance in infected CD8+ T lymphocytes but the exact mechanism(s) leading to lymphoproliferation and MCF remained unknown. To decipher ho...
• Cross-regional coordination of activity in the human brain during autobiographical self- referential processing AI翻译
  作者：Stieger, James R.; Pinheiro-Chagas, Pedro; Fang, Ying; Li, Jian; Lusk, Zoe; Perry, Claire M.; Girn, Manesh; Contreras, Diego; Chen, Qi; Huguenard, John R.; Spreng, R. Nathan; Edlow, Brian L.; Wagner, Anthony D.; Buch, Vivek; Parvizi, Josef
  作者单位：Stanford University; Stanford University; South China Normal University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; McGill University; University of Pennsylvania; Stanford University; Stanford University
  摘要：For the human brain to operate, populations of neurons across anatomical structures must coordinate their activitywithin milliseconds. To date, our understanding of such interactions has remained limited. We recorded directly from the hippocampus (HPC), posteromedial cortex (PMC), ventromedial/orbital prefrontal cortex (OFC), and the anterior nuclei of the thalamus (ANT) during two experiments of autobiographical memory processing that are known from decades of neuroimaging work to coactivate ...
• Capturing the catalytic intermediates of parkin ubiquitination AI翻译
  作者：Connelly, Elizabeth M.; Rintala-Dempsey, Anne C.; Gundogdu, Mehmet; Freeman, E. Aisha; Koszela, Joanna; Aguirre, Jacob D.; Zhu, Grace; Kamaraine, Outi; Tadayon, Roya; Walden, Helen; Shaw, Gary S.
  作者单位：Western University (University of Western Ontario); University of Glasgow
  摘要：Parkin is an E3 ubiquitin ligase implicated in early- onset forms of Parkinson's disease. It catalyzes a transthiolation reaction by accepting ubiquitin (Ub) from an E2 conjugating enzyme, forming a short- lived thioester intermediate, and transfers Ub to mitochondrial membrane substrates to signal mitophagy. A major impediment to the development of Parkinsonism therapeutics is the lack of structural and mechanistic detail for the essential, short- lived transthiolation intermediate. It is not...
• A high- light therapy restores the circadian clock and corrects the pathological syndrome generated in restricted-fed mice AI翻译
  作者：Damara, Manohar; Misra, Nisha; Chambon, Pierre
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：Time- restricted feeding (RF) is known to shift the phasing of gene expression in most primary metabolic tissues, whereas a time misalignment between the suprachiasmatic nucleus circadian clock (SCNCC) and its peripheral CCs (PCC's) is known to induce various pathophysiological conditions, including a metabolic syndrome. We now report that a unique light therapy, involving different light intensities (T ZT0- ZT12150-TZT0- ZT12 700lx, T ZT0- ZT1275-TZT0- ZT12150 lx, and T ZT0- ZT12350-TZT0- ZT1...
• Codiscovering graphical structure and functional relationships within data: A Gaussian Process framework for connecting the dots AI翻译
  作者：Bourdais, Theo; Batlle, Pau; Yang, Xianjin; Baptista, Ricardo; Rouquette, Nicolas; Owhadi, Houman
  作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology
  摘要：Most problems within and beyond the scientific domain can be framed into one of the following three levels of complexity of function approximation. Type 1: Approximate an unknown function given input/output data. Type 2: Consider a collection of variables and functions, some of which are unknown, indexed by the nodes and hyperedges of a hypergraph (a generalized graph where edges can connect more than two vertices). Given partial observations of the variables of the hypergraph (satisfying the ...
• Climate resilience through ecocultural stewardship AI翻译
  作者：Hankins, Don L.
  摘要：The climate crisis has exacerbated many ecological and cultural problems including wildfire and drought vulnerability, biodiversity declines, and social justice and equity. While there are many concepts of social and ecological resilience, the exemplar practices of Indigenous stewardship are recognized in having sustained Indigenous peoples and their countries for millennia and past climate change events. California has been at the crossroads of many of these issues, and the historic and curre...