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作者：Wei, Xiaofei; Campagna, Jesus J.; Jagodzinska, Barbara; Wi, Dongwook; Cohn, Whitaker; Lee, Jessica T.; Zhu, Chunni; Huang, Christine S.; Molnar, Laszlo; Houser, Carolyn R.; John, Varghese; Mody, Istvan
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Sapientia Hungarian University of Transylvania; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Brain rhythms provide the timing for recruitment of brain activity required for linking together neuronal ensembles engaged in specific tasks. The gamma-oscillations (30 to 120 Hz) orchestrate neuronal circuits underlying cognitive processes and working memory. These oscillations are reduced in numerous neurological and psychiatric disorders, including early cognitive decline in Alzheimer's disease (AD). Here, we report on a potent brain- permeable small molecule, DDL-920 that increases gamma-...
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作者：Alleman, Matteo; Panichello, Matthew; Buschman, Timothy J.; Johnston, W. Jeffrey
作者单位：Columbia University; Stanford University; Princeton University; Princeton University
摘要：When making decisions in a cluttered world, humans and other animals often have to hold multiple items in memory at once-such as the different items on a shopping list. Psychophysical experiments in humans and other animals have shown remembered stimuli can sometimes become confused, with participants reporting chimeric stimuli composed of features from different stimuli. In particular, subjects will often make swap errors object. While swap errors have been described behaviorally and theoreti...
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作者：Chen, Long; Ren, Ming; Zhou, Jianxian; Zhou, Xuhui; Liu, Fan; Di, Jiangtao; Xue, Pan; Li, Chunsheng; Li, Qingwen; Li, Yang; Wei, Lei; Zhang, Qichong
作者单位：Chinese Academy of Sciences; Suzhou Institute of Nano-Tech & Nano-Bionics, CAS; Nanyang Technological University; Yangzhou University; Suzhou University of Science & Technology; Shandong University
摘要：Artificial neuromorphic devices can emulate dendric integration, axonal parallel transmission, along with superior energy efficiency in facilitating efficient information processing, offering enormous potential for wearable electronics. However, integrating such circuits into textiles to achieve biomimetic information perception, processing, and control motion feedback remains a formidable challenge. Here, we engineer a quasi- solid- state iontronic synapse fiber (ISF) comprising photoresponsi...
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作者：Korovin, George; Vermaire, Ivo R.; Jin, Lishuai; Bense, Hadrien; van Hecke, Martin
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作者：You, Chunyu; Li, Xing; Hu, Yuhang; Huang, Ningge; Wang, Yang; Wu, Binmin; Jiang, Guobang; Huang, Jiayuan; Zhang, Ziyu; Chen, Bingxin; Wu, Yue; Liu, Junhan; Chen, Xiangzhong; Song, Enming; Cui, Jizhai; Zhou, Peng; Di, Zengfeng; An, Zhenghua; Huang, Gaoshan; Mei, Yongfeng
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS
摘要：Miniaturized reconstructive spectrometers play a pivotal role in on-chip and portable devices, offering high-resolution spectral measurement through precalibrated spectral responses and AI-driven reconstruction. However, two key challenges persist for practical applications: artificial intervention in algorithm parameters and compatibility with complementary metal-oxide-semiconductor (CMOS) manufacturing. We present a cutting-edge miniaturized reconstructive spectrometer that incorporates a se...
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作者：Guo, Qian; Chen, Kai-en; Gimenez-Andres, Manuel; Jellett, Adam P.; Gao, Ya; Simonetti, Boris; Liu, Meihan; Danson, Chris M.; Heesom, Kate J.; Cullen, Peter J.; Collins, Brett M.
作者单位：University of Queensland; University of Bristol; University of Bristol
摘要：Endosomal membrane trafficking is mediated by specific protein coats and formation of actin- rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27-Retromer assembly interacts with the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex which nucleates actin filaments establishing the endosomal recycling domain. Crystal structures, modeling, biochemical, and cellular validation reveal how the FAM21 subunit of ...
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作者：Luo, Yuxuan; Su, Boyang; Hung, Vincent; Luo, Yuhan; Shi, Yonghong; Wang, Guizhi; de Graaf, Dennis; Dinarello, Charles A.; Spaner, David E.
作者单位：University of Toronto; Sunnybrook Research Institute; Sunnybrook Health Science Center; University of Toronto; University of Toronto; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado Denver; University of Bonn; Radboud University Nijmegen; University of Toronto; University of Toronto
摘要：Nuclear factor kappa B (NF kappa B) is a pathogenic factor in chronic lymphocytic leukemia (CLL) that is not addressed specifically by current therapies. NF kappa B is activated by inflammatory factors that stimulate toll- like receptors (TLRs) and receptors for interleukin-1 (IL- 1) family members. IL- 1 is considered a master regulator of inflammation, and IL- 1 receptor signaling is inhibited by the IL- 1 receptor antagonist anakinra. These considerations suggested that anakinra might have ...
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作者：Plotnik, Joshua M.
作者单位：City University of New York (CUNY) System; Hunter College (CUNY); City University of New York (CUNY) System
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作者：Yuk, Jisoo; Jung, Sunghwan
作者单位：Cornell University
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作者：Csillik, Ovidiu; Keller, Michael; Longo, Marcos; Ferraz, Antonio; Pinage, Ekena Rangel; Gorgens, Eric Bastos; Ometto, Jean P.; Silgueiro, Vinicius; Brown, David; Duffy, Paul; Cushman, K. C.; Saatchi, Sassan
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Oregon State University; Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM); Instituto Nacional de Pesquisas Espaciais (INPE); United States Department of Energy (DOE); Oak Ridge National Laboratory; Wake Forest University
摘要：The Amazon forest contains globally important carbon stocks, but in recent years, atmospheric measurements suggest that it has been releasing more carbon than it has absorbed because of deforestation and forest degradation. Accurately attributing the sources of carbon loss to forest degradation and natural disturbances remains a challenge because of the difficulty of classifying disturbances and simultaneously estimating carbon changes. We used a unique, randomized, repeated, very high- resolu...
