-
作者：Snoeck, Simon; Lee, Hyun Kyung; Schmid, Marc W.; Bender, Kyle W.; Neeracher, Matthias J.; Fernandez-Fernandez, Alvaro D.; Santiago, Julia; Zipfel, Cyril
作者单位：University of Zurich; University of Lausanne; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center
摘要：Secreted signaling peptides are central regulators of growth, development, and stress responses, but specific steps in the evolution of these peptides and their receptors are not well understood. Also, the molecular mechanisms of peptide-receptor binding are only known for a few examples, primarily owing to the limited availability of protein structural determination capabilities to few laboratories worldwide. Plants have evolved a multitude of secreted signaling peptides and corresponding tra...
-
作者：Dileo, Michelle F.; Nair, Abhilash; Kardos, Marty; Husby, Arild; Saastamoinen, Marjo
作者单位：University of Helsinki; Ministry of Natural Resources & Forestry; National Oceanic Atmospheric Admin (NOAA) - USA; Uppsala University
摘要：Linking genetic diversity to extinction is a common goal in genomic studies. Recently, a debate has arisen regarding the importance of genetic variation in conservation as some studies have failed to find associations between genome- wide genetic diversity and extinction risk. However, only rarely are genetic diversity and fitness measured together in the wild, and typically demographic history and environment are ignored. It is therefore difficult to infer whether a lack of an association is ...
-
作者：Lang, Corey; Dong, Luran; Peach, Michelle
作者单位：University of Rhode Island; University of Rhode Island
-
作者：McInally, Shane G.; Reading, Alexander J. B.; Rosario, Aldric; Jelenkovic, Predrag R.; Goode, Bruce L.; Kondev, Jane
作者单位：Worcester Polytechnic Institute; Brandeis University; Brandeis University; Columbia University
摘要：Many cytoskeletal networks consist of individual filaments that are organized into elaborate higher- order structures. While it is appreciated that the size and architecture of these networks are critical for their biological functions, much of the work investigating control over their assembly has focused on mechanisms that regulate the turnover of individual filaments through size- dependent feedback. Here, we propose a very different, feedback- independent mechanism to explain how yeast cel...
-
作者：Qian, Daoyuan; Ausserwoger, Hannes; Sneideris, Tomas; Farag, Mina; V. Pappu, Rohit; Knowles, Tuomas P. J.
作者单位：University of Cambridge; Washington University (WUSTL); Washington University (WUSTL); University of Cambridge
摘要：Phase separation in aqueous solutions of macromolecules underlies the generation of biomolecular condensates in cells. Condensates are membraneless bodies, representing dense, macromolecule-rich phases that coexist with the dilute, macromolecule-deficient phases. In cells, condensates comprise hundreds of different macromolecular and small molecule solutes. How do different solutes contribute to the driving forces for phase separation? To answer this question, we introduce a formalism we term ...
-
作者：Rosenkrantz, Jimi L.; Brandorff, J. Elias; Raghib, Sanaz; Kapadia, Ashni; Vaine, Christine A.; Bragg, D. Cristopher; Farmiloe, Grace; Jacobs, Frank M. J.
作者单位：University of Amsterdam; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Amsterdam; Vrije Universiteit Amsterdam
摘要：X- linked dystonia-parkinsonism (XDP) is a severe neurodegenerative disorder resulting from an inherited intronic SINE-Alu-VNTR (SVA) retrotransposon in the TAF1 gene that causes dysregulation of TAF1 transcription. The specific mechanism underlying this dysregulation remains unclear, but it is hypothesized to involve the formation of G- quadruplexes (G4) structures within the XDP-SVA that impede transcription. In this study, we show that ZNF91, a critical repressor of SVA retrotransposons, sp...
-
作者：Diercks, Alan H.; Podolskaia, Irina S.; Murray, Tara A.; Jahn, Ana N.; Mai, Dat; Liu, Dong; Amon, Lynn M.; Nakagawa, Yoshimi; Shimano, Hitoshi; Aderem, Alan; Gold, Elizabeth S.
作者单位：Seattle Children's Hospital; University of Tsukuba; University of Tsukuba; University of Tsukuba
摘要：Toll- like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the inflammatory response to infection. Although many of the components required for the activation of the TLR pathway have been identified, the mechanisms that appropriately regulate the magnitude and duration of the response and ultimately restore homeostasis are less well understood. Furthermore, a growing body of work indicates that TLR signalin...
-
作者：Fang, Ke; Yao, Xiuhong; Tian, Yu'ang; He, Yang; Lin, Yingru; Lei, Wei; Peng, Sihan; Pan, Guohui; Shi, Haoyu; Zhang, Dawei; Lin, Honghui
作者单位：Sichuan University; Yibin University
摘要：Transcription factor ELONGATED HYPOCOTYL5 (HY5) is the central hub for seedling photomorphogenesis. E3 ubiquitin (Ub) ligase CONSTITUTIVE PHOTO MORPHOGENIC 1 (COP1) inhibits HY5 protein accumulation through ubiquitination. However, the process of HY5 deubiquitination, which antagonizes E3 ligase- mediated ubiq uitination to maintain HY5 homeostasis has never been studied. Here, we identified that Arabidopsis thaliana deubiquitinating enzyme, Ub- SPECIFIC PROTEASE 14 (UBP14) physically interact...
-
作者：Sethi, Sarab S.; Bick, Avery; Chen, Ming - Yuan; Crouzeilles, Renato; Hillier, Ben V.; Lawson, Jenna; Lee, Chia- Yun; Liu, Shih- Hao; Parruco, Celso Henrique de Freitas; Rosten, Carolyn M.; Somveille, Marius; Tuanmu, Mao- Ning; Banks-Leite, Cristina
作者单位：Imperial College London; Norwegian Institute Nature Research; National Taiwan University; University of London; University College London; Academia Sinica - Taiwan
摘要：Tracking biodiversity and its dynamics at scale is essential if we are to solve global environmental challenges. Detecting animal vocalizations in passively recorded audio data offers an automatable, inexpensive, and taxonomically broad way to monitor biodiversity. However, the labor and expertise required to label new data and fine- tune algorithms for each deployment is a major barrier. In this study, we applied a pretrained detections for each species in each dataset, calibrated classificat...
-
作者：Chen, Tianyuan; Greene, George H.; Motley, Jonathan; Mwimba, Musoki; Luo, Guan - Zheng; Xu, Guoyong; Karapetyan, Sargis; Xiang, Yezi; Liu, Chang; He, Chuan; Dong, Xinnian
作者单位：Howard Hughes Medical Institute; Duke University; Duke University; Howard Hughes Medical Institute; University of Chicago; University of Chicago; Wuhan University
摘要：Plants employ distinct mechanisms to respond to environmental changes. Modification mRNA by N 6- methyladenosine (m6A), known to affect the fate of mRNA, maybe one such mechanism to reprogram mRNA processing and translatability upon stress. However, is difficult to distinguish a direct role from a pleiotropic effect for this modification due its prevalence in RNA. Through characterization of the transient knockdown- mutants m6A writer components and mutants of specific m6A readers,we demonstra...
