33期

最新文章

• Improvement of a mouse infection model to capture Pseudomonas aeruginosa chronic physiology in cystic fibrosis AI翻译
  作者：Duncan, Rebecca P.; Moustafa, Dina A.; Lewin, Gina R.; Diggle, Frances L.; Bomberger, Jennifer M.; Whiteley, Marvin; Goldberg, Joanna B.
  作者单位：Emory University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Centers for Disease Control & Prevention - USA; University System of Ohio; Case Western Reserve University; Dartmouth College
  摘要：Laboratory models are central to microbiology research, advancing the understanding of bacterial physiology by mimicking natural environments, from soil to the human micro- biome. When studying host-bacteria interactions, animal models enable investigators to examine bacterial dynamics associated with a host, and in the case of human infections, animal models are necessary to translate basic research into clinical treatments. Efforts toward improving animal infection models are typically based...
• Electron transport through two interacting channels in Azurin-based solid- state junctions AI翻译
  作者：Li, Ping'an; Bera, Sudipta; Kumar-Sexena, Shailendra; Pecht, Israel; Sheves, Mordechai; Cahen, David; Selzer, Yoram
  作者单位：Tel Aviv University; Weizmann Institute of Science; SRM Institute of Science & Technology Chennai; Weizmann Institute of Science
  摘要：The fundamental question of what is the transport path of electrons through proteins? initially introduced while studying long-range electron transfer between localized redox centers in proteins in vivo is also highly relevant to the transport properties of solid-state, dry metal-protein-metal junctions. Here, we report conductance measurements of such junctions, Au- ( Azurin monolayer ensemble)- Bismuth (Bi) ones, with well-defined nanopore geometry and similar to 10(3) proteins/pore. Our res...
• Computational evolution of social norms in well-mixed and group-structured populations AI翻译
  作者：Murase, Yohsuke; Hilbe, Christian
  作者单位：RIKEN; Max Planck Society
  摘要：Models of indirect reciprocity study how social norms promote cooperation. In these models, cooperative individuals build up a positive reputation, which in turn helps them in their future interactions. The exact reputational benefits of cooperation depend on the norm in place, which may change over time. Previous research focused on the stability of social norms. Much less is known about how social norms initially evolve when competing with many others. A comprehensive evolutionary analysis, ...
• Maternal manipulation of offspring size can trigger the evolution of eusociality in promiscuous species AI翻译
  作者：Rees-Baylis, Ella; Pen, Ido; Kreider, Jan J.
  作者单位：University of Groningen; University of Bern
  摘要：Eusocial organisms typically live in colonies with one reproductive queen supported by thousands of sterile workers. It is widely believed that monogamous mating is a precondition for the evolution of eusociality. Here, we present a theoretical model that simulates a realistic scenario for the evolution of eusociality. In the model, mothers can evolve control over resource allocation to offspring, affecting offspring's body size. The offspring can evolve body- size- dependent dispersal, by whi...
• Structure of biofilm- forming functional amyloid PSMα1 from aureus AI翻译
  作者：Hansen, Kasper Holst; Byeon, Chang Hyeock; Liu, Qian; Drace, Taner; Boesen, Thomas; Conway, James F.; Andreasen, Maria; Akbey, Umit
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Aarhus University; Aarhus University; Aarhus University
  摘要：Biofilm- protected pathogenic Staphylococcus aureus causes chronic infections that are difficult to treat. An essential building block of these biofilms are functional amyloid fibrils that assemble from phenol- soluble modulins (PSMs). PSM alpha 1 cross- seeds other PSMs into cross-beta amyloid folds and is therefore a key element in initiating biofilm formation. However, the paucity of high- resolution structures hinders efforts to prevent amyloid assembly and biofilm formation. Here, we pres...
• Spatiotemporally controlled microvortices provide advanced microfluidic components AI翻译
  作者：Saito, Makoto; Arai, Fumihito; Yamanishi, Yoko; Sakuma, Shinya
  作者单位：Kyushu University; University of Tokyo
  摘要：Microvortices are emerging components that impart functionality to microchannels by exploiting inertia effects such as high shear stress, effective fluid diffusion, and large pressure loss. Exploring the dynamic generation of vortices further expands the scope of microfluidic applications, including cell stimulation, fluid mixing, and transport. Despite the crucial role of vortices' development within sub- millisecond timescales, previous studies in microfluidics did not explore the modulation...
• Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function AI翻译
  作者：Hayashi, Hideki; Mak, Tak Wah; Tanaka, Yoshimasa; Kubo, Yoshinao; Izumida, Mai; Urae, Ryuji; Matsuyama, Toshifumi
  作者单位：Nagasaki University; Nagasaki University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Hong Kong; Nagasaki University; Nagasaki University
  摘要：We developed a highly sensitive assay for detecting protein-protein interaction using chimeric receptors comprising two molecules of interest in the extracellular domain edly more sensitive than the NanoBiT system, currently considered one of the best detection systems for protein interaction. Employing chimeric receptors with extracellular domains from the IFN gamma or IL- 2 receptor and the intracellular domains of IFNAR1/2, the IFNARRS system effectively identifies low IFN gamma or IL- 2 le...
• Understanding the relationship between intergenerational mobility and community violence AI翻译
  作者：Mann, Olivia; Edin, Kathryn J.; Shaefer, H. Luke
  作者单位：Princeton University; University of Michigan System; University of Michigan
  摘要：Violence is a key mechanism in the reproduction of community disadvantage. The existing evidence indicates that violence in a community impacts the intergenerational mobility of its residents. The current study explores the possibility of a reverse relationship. This study provisionally tests the hypothesis that depressed intergenerational mobility in a community may also spark subsequent community violence. We deploy a county measure of intergenerational mobility captured during early adultho...
• The consequences of AI training on human decision-making AI翻译
  作者：Treiman, Lauren S.; Ho, Chien-Ju; Kool, Wouter
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：AI is now an integral part of everyday decision-making, assisting us in both routine and training data is unbiased. However, we report five studies that show that people change their behavior to instill desired routines into AI, indicating this assumption is invalid. To show this behavioral shift, we recruited participants to play the ultimatum game, where they were asked to decide whether to accept proposals of monetary splits made by either other human participants or AI. Some participants w...
• Anaplasma phagocytophilum effector EgeA facilitates infection by hijacking TANGO1 and SCFD1 from ER-Golgi exit sites to pathogen- occupied inclusions AI翻译
  作者：Wang, Lidan; Lin, Mingqun; Hou, Libo; Rikihisa, Yasuko
  作者单位：University System of Ohio; Ohio State University
  摘要：The obligatory intracellular bacterium Anaplasma phagocytophilum causes human granulocytic anaplasmosis, an emerging zoonosis. Anaplasma has limited biosynthetic and metabolic capacities, yet it effectively replicates inside of inclusions/vacuoles of eukaryotic host cells. Here, we describe a unique Type IV secretion system (TOSS) effector, ER-Golgi exit site protein of Anaplasma (EgeA). In cells infected byAnaplasma, secreted native EgeA, EgeA-GFP, and the C- terminal half of EgeA (EgeA-C)-GF...